Rapamycin: The Gold Standard of Life Extension Drugs
Rapamycin is, by far, the world’s leading candidate for an effective and accessible longevity (anti-aging) drug. Nothing else comes close. If you’re interested in a longer, healthier life you may want to read on and join the thousands of people already using it to improve their lives. We estimate about 20,000 people are taking rapamycin for longevity purposes today, as of Sept. 2024, and increasing quickly, at about 300% per year. At a minimum, you probably want to learn as much as you can about it and keep a close eye on the research going forward.
Rapamycin is considered by many geroscience researchers to be the “gold standard” of longevity drugs; the healthy lifespan improvement seen in animal trials are consistently the best of any drug (typically 15% to 30% lifespan improvement). It increases healthspan and lifespan in every organism its been tested in; from yeast, to flies, to worms, to fish, to mice, to rats, and now monkeys (over a billion years of evolution). It has the most reproducible life extension effect, having been tested and retested by many different labs around the world in a wide variety of different species of organisms and animals. Over 29 rapamycin lifespan mice studies have been completed with positive results. Rapamycin also seems to slow, or reverse, aging in many different organs. And, rapamycin is an FDA -approved drug that has been in use for over 20 years, by hundreds of thousands of people (in cancer and organ transplant treatment regimens) and its now classified as a generic drug, so it is inexpensive to buy.
BUT, rapamycin is also a serious drug that can have serious side effects, depending on how its dosed and other factors. This is not a risk-free drug (no drugs are). If you are considering using rapamycin be SURE to spend a few months to read the literature here, and watch the videos, so you can make an informed decision, ideally working in concert with a doctor. There can be negative side effects (typically dose-dependent) like increases in lipid levels or blood glucose levels, so many people do periodic (every 3 months or so) blood testing to check for these potential issues, and make adjustments based on test results Don’t just rush into taking rapamycin because you heard a podcast mention it. Take your time, read as much as you can of the information below, and follow the discussions in our forum.
Rapamycin Basics
Learn More about Rapamycin
Benefits of Rapamycin
Side Effects of Rapamycin
Tracking Your Biomarkers and Results
People Write About Their Experiences with Rapamycin
Rapamycin, etc. for Aging Skin and Hair, Oral Health
Rapamycin and Exercise / Muscle Growth
Surveys & Polls of Rapamycin Users
How to Use / Dose Rapamycin in Anti-aging Applications
How to get Rapamycin Prescription, How to Buy Rapamycin
Why Consider Everolimus instead of Rapamycin (Sirolimus)
Rapamycin for Dogs, Cats, Horses
Other Top Longevity Drugs:
IGF-1 Lowering Drugs for Longevity
Anti-Aging Supplements:
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Astaxanthin (Preliminary NIA ITP results suggest a 12% median lifespan improvement in mice)
- Glycine and Gly/NAC
- Protandim, a mixture of botanical extracts that activate Nrf2, extended median lifespan in males only. (7% median lifespan increase)
Other Longevity Strategies (treatments):
Longevity Clinics
Longevity clinics are health optimization and preventative medicine focused healthcare centers that provide health evaluations and early risk identification of potential disease processes. We believe that this preventative focus is the future of healthcare (compared to the “sick care” of today where they wait until you get sick before they do much of anything), but right now the full services are only available to people who want to spend $5,000 to $100,000 per year. Following are some details on perhaps the leading longevity centers in the world today, and the services they offer.
- The Longevity Clinic Will See You Now—for $100,000 (WSJ)
- The quest to legitimize longevity medicine (MIT)
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Longevity Clinics: What They Are, Services & More
Examples of Longevity Clinics (Detailed Presentations on each)
- Longevity Clinics: Dr. Andrea Maier, Chi Longevity, Singapore
- Longevity Clinics: Fountain Life, Mona Ezzat – Velinov, MD
- Longevity Clinics: Cleveland Clinic, Wellness and Preventive Medicine, Michael F. Roizen MD
- Longevity Clinics: Human Longevity Inc., Dr. David Karrow
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Longevity Clinics: Dr. Mark Hyman, Function Health (Functional Health seems to focus on health testing, starting at $400 or so for a suite of tests).
The History of Rapamycin
