List of all the Mouse Studies Showing Rapamycin Lifespan Extension

[RapAdmin]

For people who like data, the attached document is the full list, compiled by Dudley Lamming, of all the mouse studies that have been done with rapamycin and which show life extension (only a few studies, in rare genetic backgrounds have not shown lifespan improvement). Rapamycin is by far the most rigorously studied compound that consistently and significantly increases lifespan and healthspan.

Additional to the below list of all the rapamycin mouse studies is this Meta-Analysis of 29 Experiments Evaluating the Effects of Rapamycin on Life Span in the Laboratory Mouse.

Full List of Rapamycin Mouse Life Extension Studies (PDF) below:

preprints202102.0491.v1-6.pdf (391.7 KB)

[Maveric78]

I thought this was interesting:

A recent study, moreover, has complicated the picture, by demonstrating that rapamycin treatment initiated at 4 months of age decreased life span of db /db diabetic mice in both sexes (C57BL/KsJ background) (15). This is likely due to deleterious effects of rapamycin on glucose homeostasis, which is unbalanced in db /db mice as evidenced by hyperglycemia and hyperinsulinemia

[RapamycinCurious]

Continuing the discussion from How a cheap, generic drug became a darling of longevity enthusiasts:

@RapAdmin

Actually:

Mouse lifespans dosed with higher levels of rapamycin have been increased as much as 26% to 30%: List of all the Mouse Studies Showing Rapamycin Lifespan Extension

I don’t see any reports there of life extensions greater than 26% — and that was in female mice starting at age 9 months (equivalent to a human in their early 30s), so not widely generalizable. Also that was median lifespans: there seems to be a barrier of a little over 10% in maximum LS regardless of dose or age of initiation.