Very Good Longevity Biology Educational Resources

RapAdmin · 2022-11-28T20:14:31.820Z

This is a great resource for anyone interested learning more about longevity Biology. I highly recommend the longevity journal club document below. Check it out! (Note: I’ve included some PDFs of the documents at the end of this post, for easier access).

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Martin Borch Jensen

@MartinBJensen

Another public resource from the Longevity Apprenticeship 🎁: Curriculum, presentations, and notes from our year-long journal club. Intended for people trying to learn #AgingBiology who want a deeper understanding after reading a few FAQs and papers. docs.google.com/document/d/16e…

5:09 PM - 28 Nov 2022 60 14

docs.google.com

Longevity Apprenticeship Journal Club

Longevity Journal Club 2022 Edition Curriculum Creator Martin Borch Jensen Presenters Divya Cohen Tara Mei Lada Nuzhna Kush Sharma Madison Ueland INTRODUCTION Goals The goals of the Longevity Journal Club are threefold: Understand the...

Inside the above Google doc, are links to many other resources like these slide presentations

docs.google.com

2/6: Rapamycin

Discussion Summary Paper(s): Harrison, D., Strong, R., Sharp, Z. et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392–395 (2009). https://doi.org/10.1038/nature08221 Presented by Kush Sharma on...

docs.google.com

JC_220522

Discussion Summary Paper(s): No single paper Presented by Tara Mei on 05/22/2022 Longevity Interventions in Humans

docs.google.com

Sirtuins, resveratrol

Discussion Summary Paper(s): Summary - Garber, K. A mid-life crisis for aging theory. Nat Biotechnol 26, 371–374 (2008). https://doi.org/10.1038/nbt0408-371, Primary data refutations Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári, M.,...

docs.google.com

NIA Interventions Testing Program

Discussion Summary Paper(s): https://www.nia.nih.gov/research/dab/interventions-testing-program-itp Presented by Madison Ueland on 1/30/2022 NIA Interventions Testing Program

docs.google.com

Heterochronic Parabiosis

Discussion Summary Paper(s): Primary paper: Conboy, I., Conboy, M., Wagers, A. et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433, 760–764 (2005). https://doi.org/10.1038/nature03260; Historical...

docs.google.com

Nutrient Sensing in Longevity

Discussion Summary Paper(s): Finkel, T. The metabolic regulation of aging. Nat Med 21, 1416–1423 (2015). https://doi.org/10.1038/nm.3998 Presented by Madison Ueland on 2/06/2022 Nutrient Sensing

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Martin Borch Jensen

@MartinBJensen

The Longevity Apprenticeship is a training program using direct mentorship and hands-on work on real projects, to develop people combining good taste in #AgingBiology with the capacity to lead teams and organizations 🧑🏽‍🎓. twitter.com/MartinBJensen/…

Martin Borch Jensen @MartinBJensen

"The [#Aging] field is poised for radical impact, but making this reality will take a lot of effort. The Longevity Apprentice role is for people who want to play a part in that, but aren’t sure how." https://t.co/atZuodsTpq Please RT!

5:09 PM - 28 Nov 2022 7 1

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Martin Borch Jensen

@MartinBJensen

The journal club goes through landmark discoveries and topics, with a focus on primary research papers 📰. By discussing the papers with an experience geroscientist, non-biologists could read between the lines to understand strong claims, possibility, and limitations. https://t.co/Z68ToPOLYi

5:09 PM - 28 Nov 2022 2

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Martin Borch Jensen

@MartinBJensen

The most comprehensive #Aging primer is @ArtirKel's FAQ: nintil.com/longevity. It does a great job of introducing the field, and distilling the science for non-biologists. Bonus points for contextualizing how biology is different from engineering.

4:55 PM - 20 Dec 2020 28 2

nintil.com

Nintil - The Longevity FAQ

The internet's best blog!

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Martin Borch Jensen

@MartinBJensen

@LauraDeming's FAQ has a great list of interventions that extend #Lifespan in mice (@justsaysinmice go ahead), and their clinical stage: ldeming.com/longevityfaq. Note that mice are not humans! And some of these studies haven't been independently replicated. Still, exciting data!

4:55 PM - 20 Dec 2020 14

Laura Deming

Longevity FAQ — Laura Deming

A beginner's guide to longevity research

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Martin Borch Jensen

@MartinBJensen

@LifespanIO also has a great overview of clinical trials for drugs that likely target #AgingMechanisms: lifespan.io/road-maps/the-… Note that, in my opinion, many of these are going to fail. Some because fanciful drugs/poor execution, some because clinical trials fail.

4:56 PM - 20 Dec 2020 13 1

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Martin Borch Jensen

@MartinBJensen

@KarlPfleger has the best overview of #Biotech companies working on #AgingBiology (explicitly or de facto): agingbiotech.info/companies/. He includes publicly available information on company stage, product, key people, and summary statistics across companies.

4:56 PM - 20 Dec 2020 15 1

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Martin Borch Jensen

@MartinBJensen

OK, let's add nuance. Most importantly, understand that #Biology is full of nonlinear effects. Text- & #PopSci books may have you thinking biology works as in left pic below. The reality (of one pathway) is 10x more complex than the right pic, incl. lots of circular feedback. https://t.co/8ixdbhlbpe

12:22 AM - 14 Apr 2021 19

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Martin Borch Jensen

@MartinBJensen

Non-linear interactions means that results are often context-specific. A protein will kill one cell type and protect another. Nothing is "better" or "worse", but shift a system in a way that may be desired. #Aging is a complex system to tune, not a single pathway to turn down.

12:22 AM - 14 Apr 2021 11

Longevity Apprenticeship Journal Club sm.pdf (1.7 MB)

2_6_ Rapamycin-compressed.pdf (176.3 KB)

RapAdmin · 2022-11-28T20:57:39.798Z

Additional Longevity presentations:

Nutrient Sensing in Longevity.pdf (943.6 KB)

LongevityInterventionsJC_220522.pdf (2.6 MB)

NIA Interventions Testing Program.pdf (883.9 KB)

Heterochronic Parabiosis.pdf (479.0 KB)