I’m not familiar with either of these specific products, so I will respond in the general sense.
Broadly speaking, I don’t believe I’ve heard of any of the most common anti-aging / longevity supplements that are strictly contra-indicated for use with rapamycin - but there are some that impact rapamycin you should be aware of so please read below.
There are many interactions with herbs, fruits, supplements, etc. that people should be aware of. Some will significantly increase the level of rapamycin (sirolimus) in your blood (which may be a desirable or undesirable effect - but be aware and discuss with your doctor) and also interact with other medications you may be taking - here is a list and some resources to read up:
Citrus fruits can have an impact your your rapamycin / sirolimus blood levels. See this discussion: Rapamycin and Grapefruit Juice
Many supplements can also inhibit (and in some cases, activate) CYP3A4 and interact with many of the same medications.
Supplements that inhibit CYP3A4 enzyme
Below is a list of some of the supplements known to inhibit CYP3A4. More details about each are found in our linked Product Reviews and CL Answers:
Be aware that St. John’s wort can activate CYP3A4, causing a decrease in the activity of many drugs.
Source: CYP3A4 Inhibitors - Grapefruit & More - ConsumerLab.com
More info on Tumeric: Turmeric Linked to Liver Damage, Decrease in Rapamycin Bioavailability
Rapamycin and Astaxanthin
Our forum members have found research that suggests that rapamycin blocks some of the benefits of Astaxanthin. See the discussion thread here: Rapamycin blocking Astaxanthin.
Because of this possibility some people are not taking their astaxanthin supplements on the day they dose rapamycin, and the day following. They are resuming their astaxanthin on day 2 after dosing rapamycin (under the assumption that blood levels of rapamycin are then low enough to interfere less with Astaxanthin.
Other Compounds that Interact with Rapamycin / Sirolimus
I also recommend you read up on this discussion thread on our site about compounds and drugs that interact with rapamycin / sirolimus: Improve Bioavailability of Rapamycin (2)
There are also some other compounds, like CBD (and surprisingly enough, high Dose Parsley ) that seem have an impact on how your body processes rapamycin / sirolimus. So if you ever try CBD I’d recommend you read up on that possible issue:
Reports in the literature also suggest that cannabidiol administration resulted in increased serum levels of everolimus, sirolimus, or tacrolimus; the mechanism of this interaction is not clear.
NAD Promoters / Resveratrol Supplementation
The only other thing I’d note is that with regard to the NAD / Resveratrol supplement - that if you take it and it makes you feel better then thats fine - I’ve not seen any literature to suggest those compounds will harm you.
However, in terms of cost-effectiveness of NAD boosters and Resveratrol they have a very mixed history in terms of their effectiveness in terms of longevity increases and I don’t take it because I don’t think the results indicated by the research and that I experienced when trying them (no obvious benefit in either situation) justify the high price. Rapamycin has decades of research, and is quite inexpensive by comparison.
NAD boosters failed to increase lifespan at all in the best, long term study (The National Institutes of Aging Intervention Testing Program run by Richard Miller) that has been done on Nicotinomide Riboside (the most popular NAD booster), as can be seen in this paper: 17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex - PMC
I also recommend you listen to this podcast where Matt Kaeberlein talks about these compounds: https://www.youtube.com/watch?v=T1ACcAwn18Q&t=112s
In another podcast for his subscribers on this topic, here are some points they make:
NAD precursors :
- Having said that NAD and the intermediates in the NAD biosynthesis and breakdown pathways are highly interconvertible
- This is something that is emerging, that our cells are really quite able to take up precursors of NAD in that NAD pathway.
- There could be a salvage pattern here where if you give somebody intravenous NAD, it’s possible that they’re turning it into NMN or NR… and then right back to NAD in the cell, if the NMN or NR gets transported into the cell
- People are studying NAD precursors (nicotinamide riboside and nicotinamide mononucleotide) primarily in the context of aging
- There are still real questions around the efficacy with which those molecules are taken up through the gut once they get into circulation taken into cells
- But there are other NAD metabolites like nicotinamide, which can be interconverted
- What seems to be the case is that even when you treat with, say an NAD cursor, it may not get into circulation as those molecules, but they can be interconverted in circulation or in cells
- The real questions are:
- 1 – Do those molecules have a big effect on NAD homeostasis and NAD levels in cells and tissues?
- 2 – Do we see functional improvements in those cells and tissues that then you would predict would turn into improved health span, potentially increased lifespan in laboratory animals?
What’s with all the hype?
- Two molecules, NR and NMN
- These are orally bioavailable
- They are safe from an acute toxicity standpoint, there’s not anything that one needs to be concerned with here
- These are over the counter supplements
- For as much hype as there is around this, we really don’t have a lot of great data to point to that these things are improving lifespan
What does Matt Kaebelein make of this hype in the face of a lack of clear data?
- This is the crux of the issue
- When evaluating different interventions that potentially affect the biology of aging, Matt asks himself: What’s the best data that these things actually have a strong impact?
- And in this particular case, when referring to normative aging…
- we don’t want to be working in a short-lived background that has some specific pathology
- And in this scenario, Matt is not confident that NR or NMN can increase lifespan in wild type mice
So what is the most compelling evidence?
Study by Zhang et al., 2016:
- This study reported that late life administration of nicotinamide riboside in C57 black 6 mice had a small, but statistically significant effect on survival
- As was noted in Figure 4 above, the controls in that experiment were shortlived and the experiments where the controls are shortlived, if the effect of the intervention small, that’s often not reproducible
- And in this case, when the ITP attempted to test nicotinamide riboside, they saw no effect on lifespan or any other real phenotype
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