A lot of evidence that grapefruit increases rapamycin absorption and it’s suggested it does so by inhibiting CYP3A4.
Piperine does that too and is noted to increase absorption of other supplements like curcumin.
Will a bit of pepper increase effective rapamycin dosage like grapefruit does?
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LukeMV
#2
I would guess that it probably does
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I’m not sure what the dose/response relationship is, but there is some effect. See this thread: Rapamycin Interactions with Other Food, Drinks, Supplements and Drugs
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Tested piperine’s effect on rapamycin absorption, for me it increases bioavailability by 75% (see table below)
| Date |
Rapamycin (mg) |
Piperine (mg) |
48h sirolimus, blood (ng/ml) |
| 3/15/2025 |
6 |
0 |
1.9 |
| 3/22/2025 |
2 |
10 |
1.1 |
The 3/15 dose was standalone, just rapamycin and water. On 3/22, rapamycin and piperine were taken at the same time.
Any thoughts on a reasonable target blood level 48h after dosing when rapamycin is taken weekly?
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Thank you for testing this!
