#1

Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging

Carotenoids have gained special interest during the last decades, due to their strong antioxidant, repairing, antiproliferative, anti-inflammatory, and potential antiaging effects. They can be used to prevent oxidative stress-related diseases and chronic inflammation. Astaxanthin is one of the most powerful carotenoid on the market. In this review, special focus is oriented towards these compounds.

Recent human studies elaborate on the safety perspectives of natural astaxanthin, and so far, no documented negative effects have been found over its 20 years of consumption as a dietary [48]. Clinical studies have found that natural astaxanthin supplementation improved blood flow in humans [49] and enhanced blood rheology by increasing the flexibility of erythrocyte membranes [50].

Astaxanthin emerged in the spotlight because of its potential pharmacological effects, including anticancer [44, 51, 52], antidiabetic [53, 54], anti-inflammatory [55], immune-stimulating effects [44, 52], and antioxidant activities [55–59] as well as neuro-, cardiovascular, ocular-, and skin-protective effects [60–64]. Studies found that astaxanthin reduces the oxidative stress caused by hyperglycemia in pancreatic β-cells and improves glucose and serum insulin levels in diabetes [65]. Furthermore, it has been suggested that astaxanthin is a potential therapeutic agent against atherosclerotic cardiovascular disease [66]. In an elegant work, Barros et al. showed that “astaxanthin can directly cross the blood-brain barrier to reach different mammalian brain regions” [64, 67, 68]. Here, we summarize the effects of astaxanthin on metabolism, insulin resistance, and type-2 diabetes mellitus; furthermore, its advantages on muscle performance, recovery, and atrophy, and effects in the central nervous system and the skin will also be discussed.

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#3

It seems that with this new data coming out of the NIA ITP program, astaxanthin is becoming one of the better, if not the best, evidence-supported supplements to help slowing aging.

Preliminary NIA ITP study results are suggesting a 12% median lifespan (in males) improvement in the mouse studies (the best of any supplement).

In the NIA ITP compounds listing - they say they are testing 4,000ppm of Astaxanthin in the mice. If someone has the time - please convert this to estimated human dosing levels in terms of mg/kg.

Richard Miller (NIA ITP program) said in his last interview that New, as of yet unpublished, ITP study astaxanthin improves lifespan in males (not females).

Video queued up for the Astaxanthin commentary below:

Astaxanthin Related Research:

A good overview of the state of the science on Astaxanthin (on Examine.com):

Other research:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778137/

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Can you share your Longevity / HealthSpan Regime?
#4

Astaxanthin: How much is too much? A safety review

An interesting paper from Europe that did in-depth analysis on several brands of astaxanthin.

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#5

Astaxanthin Products Review - Excerpt:

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astaxanthin-per-serving-2022
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cost-per-4-mg-astaxanthin-2022457×670 67.7 KB

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#6

Any endogenous super molecule found in whole foods (wild salmon), worthy of consideration.

I added 10mg/day Astaxanthin 10mg 180 Softgels by Waka Tani

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#7

Now Foods is also a good brand I’m familiar with and which typically gets good reviews in Consumerlab - and it also works out to about $0.12 per 4mg (for comparison with the above table):

Also at iHerb, $16.13

https://www.iherb.com/pr/now-foods-astaxanthin-10-mg-60-softgels/38292

#8

RapAdmin and anyone else. You taking Astaxanthin and if so, what dose?

#9

Not yet - but probably will. We need to translate the 4,000ppm from the mouse studies to human studies. Perhaps someone can do that and show the calculations.

Here is an example one person did for Meclizine / Dramamine research:

From Louis:

My calculation shows that the ITP fed the mice a human equivalent dose of about 730mg of Dramamine per day for a 70kg person.

Here is the math:

The ITP used 800ppm in food (see attached photo). And 800ppm is 0.08%. A typical mouse weighs about 0.025kg and eats about 4g of food per day, so 0.08% is 3.2mg of Dramamine for the mouse per day. That is a dose of 3.2mg/0.025kg=128mg/kg. Divide by 12.3 to allometrically scale to humans, to get a human equivalent dose of (128mg/kg)/12.3=10.4mg/kg. So for a 70kg human, that would be 728mg of Dramamine per day.

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#10

I have taken /take it on and off, for several year when having any type of X-ray. I have taken/take several grams, yes grams. Several days before, the day and after. Use to purchase the Vitamin Shoppe brand.

FWIW, I recently have been using
Liposomal Astaxanthin Supplement that is 24mg per capsule. The last two bottles cost was less than .25¢ per capsule, 120 capsules was $23.59 with a coupon

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#12

Using the meclizine calculation.

4000ppm / 800ppm
X / 728mg (70kg person)

5 * 728mg = 3.64g/day for a 70kg person ?

2 Likes
New Richard Miller / ITP Paper: Astaxanthin and meclizine extend lifespan 12%, 8% respectively
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#13

LifeExtension include 2mg in their EPA/DHA fish oil capsules.
If I’m eating the wild sockeye salmon (very pink so high in Astaxanthin) I’d only take two, if not I’ll take three or four each day.

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#14

A typical 10kg wild salmon with approximately 40 mg Astaxanthin/kg flesh, would convert 3.64g/day of Astaxanthin into eating over 9 whole salmons/day.

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#15

Big astaxanthin believer and took it for years prior to rapamycin. Since starting rapamycin I get lower extremity muscle twitches after using it. They go away after stopping the astaxanthin. Some interaction between them. Not certain what’s causing it.

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#16

This study showing PPAR delta as an activator of pancreatic cancer got me wondering if astaxanthin may be problematic. Astaxanthin is a PPAR alpha agonist and I wanted to know if it affected the other PPAR’s as well.

Fortunately it appears that it does not act as a delta agonist, and in fact has no affect.

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#17

What dose of Astaxanthin were you using in this situation?

#18

12mg per day. A fairly high dose so I’m thinking that maybe 4 mg would be okay.

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#19

I get similar random muscle twitching, dramatically worsened by any kind of curcumin supplement (so I avoid curcumin). Took me forever to link it to curcumin, and I still have no idea what the mechanism could be.

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Lower Extremity Twitches with Rapamycin and Curcumin
#20

Well, now that you mention it, curcumin also does it as does green tea extract. I have to avoid all of them for the first 3-4 days after my rapamycin dose or the twitching is a real nuisance, and also I start thinking that I have some neuromuscular disease.
What could it be? Is it some kind of excessive neuromuscular activation? What’s the role of rapamycin.
I think curcumin and green tea inhibit mTOR to a certain degree. Does it excessively inhibit muscle cell proliferation when used in combination and the muscles compensate by some sort of hyperactivation?

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#21

I take one of these daily for several years now, never noticed any effect.

#22

Thanks. That could explain it.