Lower Extremity Twitches with Rapamycin and Curcumin

[Pender]

I developed muscle twitches in my calves and feet after taking Rapamycin and Curcumin. I spotted two forum users who described almost this exact same problem:

Astaxanthin: A Potential Treatment in Disease and Aging, Lifespan Increase

Big astaxanthin believer and took it for years prior to rapamycin. Since starting rapamycin I get lower extremity muscle twitches after using it. They go away after stopping the astaxanthin. Some interaction between them. Not certain what’s causing it.

Astaxanthin: A Potential Treatment in Disease and Aging, Lifespan Increase

I get similar random muscle twitching, dramatically worsened by any kind of curcumin supplement (so I avoid curcumin). Took me forever to link it to curcumin, and I still have no idea what the mechanism could be.

Has anyone else experienced this?

[Davin8r]

Yes! I was tortured with muscle twitching (i.e. fasciculations) on/off for years (thinking at one point I may have had early symptoms of ALS) until I finally figured out it was the curcumin, or at least dramatically worsened by curcumin. I have no idea what kind of mechanism could have been at play.