My urologist is a huge (kidding aside) encourager of tadalafil for urinary and prostate health. Small dose every day 2.5 to 5mg for longevity. I’ve been using 3 plus years now.
Should consider for older guys 8 weeks on… 2 weeks off cycling. To maintain effectiveness.
Additionally enhances muscle repair and exercising… use before workouts. Helps recovery post exercise. An anti-inflammatory. Helps on cognitive decline… and much more.
Found this on YouTube for using tadalafil for anti-aging and longevity. Hmmm… the first brief bit is very medical… but gets to lay person quickly. So hang in there.
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KarlT
#2
What is this recommendation based on? A study? Your Urologist? Or personal experience?
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It’s in the video after 14 minutes.
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PBJ
#4
I’m guessing it is based on bro-science.
There is no evidence to suggest that tadalafil directly down-regulates receptors, specifically in the context of its primary use for ED or BPH. Down-regulation typically refers to a decrease in the number of receptors or their sensitivity on the surface of cells, usually due to prolonged exposure to a stimulus or drug.
Tadalafil acts on the PDE5 enzyme rather than directly on receptors. Over time, the body may develop a certain level of tolerance to drugs that work on receptors, but this is different from receptor down-regulation. In the case of tadalafil, tolerance development appears to be minimal, and its long-term use has not been associated with significant down-regulation or desensitization of receptors.
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Thanks for that explanation. And, I have never thought of cycling for the past 3+years. My urologist didn’t think it was necessary to cycle. I only considered it after the video explanation.
Your additional thoughts on how tadalafil works has me thinking - heck I’ve been using it this long with no issues and it definitely is working - night, morning and in-between - so maybe not cycle. I don’t have ED and my urologist specifically recommended tadalafil for overall health - not ED.
On that topic tho - I have read more than once at 30 years 30% of guys have ED. at 40 years 40% and 50 years has 50% ED. And on etc. I have no reason to think this is false - just glad I am not in those statistics. And, I don’t plan to be.
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The small chance of priapism scares me
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A prolonged erection of the penis, usually without sexual arousal.
We have different opinions of scary… hahaha.
That was everyday for me in high school.
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This is much worse, decompression is needed… 
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I’m glad I’m in the lucky 50% then for age 50 guys.
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Agetron
#10
Oh…oh!
That would be something more along the lines of a trimix injection reaction. First you have to have balls (literally) to stick a needle in your Johnson.
Gotcha. Yeah… draining the blood out surgically… possibly losing your member. Okay.
Didn’t think you could get priapism from tadalafil.
Seems pretty unlikely.
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Anyone done any research on this… is Lee Hebel’s comment accurate?
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Unfortunately I have never awoken with an erection. I didn’t realize that was a thing.
However I never have a problem when duty calls. 
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I think you may be forgetting your teenage years…
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adssx
#16
I checked a bit and found:
Men without physiological erectile dysfunction or severe depression experience nocturnal penile tumescence, usually three to five times during a period of sleep, typically during rapid eye movement sleep.
On average, one has 3–5 episodes of NPT each night, and each episode lasts 30–60 minutes, although the duration is reduced with advanced age.
We’re giving it a lot of text here because it’s commonly discussed — but before we get into the specifics, we want to be clear: The NPT test is outdated and not really very accurate.
Morning wood is a good indicator of both erection health and general health. If you usually wake up with an erection, it’s a good sign that your body is physiologically capable of achieving an erection and that you likely aren’t affected by physical ED. It’s also perfectly normal to occasionally not wake up with an erection. Most men get an erection anywhere from one to five times during sleep. Sometimes, you’ll snap out of sleep at the wrong moment and wake up without an erection. As long as it’s occasional, it’s usually not a problem. However, if you frequently wake up without an erection, there’s a risk that it could be the sign of an underlying health issue such as physical ED. If you’re concerned that you’re not getting nocturnal erections you can try a simple postage stamp test. You take a length of connected postage stamps and secure them to your flaccid penis prior to going to sleep. If the perforated connections of the stamps are torn when you wake up it’s evidence that you’re experiencing nocturnal erections. It’s not a perfect test, but it’s something simple you can do by yourself.
The most common causes of infrequent or no morning wood are hormonal issues, such as low testosterone, as well as health conditions such as obesity, high blood pressure, diabetes and high cholesterol.
Another factor that affects the frequency of morning wood is age. Older men – particularly men in their 60s and 70s – are less likely to experience frequent morning wood than younger men.
If you stop experiencing NPT, this may be an early sign of an underlying medical problem. Pay attention to how often you experience morning wood. If it stops, speak with a doctor.
However, I struggled to find data. I found this but it is in patients “after nerve-sparing radical prostatectomy (nsRP)”:
Effect of Tadalafil Once Daily on Penile Length Loss and Morning Erections in Patients After Bilateral Nerve-sparing Radical Prostatectomy: Results From a Randomized Controlled Trial 2015
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tj_long
#18
Tadalafil seems to make my reflux worse, so I stop using it. “There are no solutions, only trade-offs”.
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tj_long
#20
I might trying 2.5mg 3 times a week.
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