#9

Yeah I wanted to throw the kitchen sink at it! My LDL was around 150, ApoB at 145. In most people who overproduce, they still get benefit from ezetimibe. And vice versa. Thanks for commenting, hope some others post their stack

2 Likes
#10

We have discussed this a little in another thread. It is one thing I am considering adding, My PSA is 0.6 which I am happy with for age 47, but I definitely want to look into trying it.

1 Like
#11

I’d say tadalafil, empagliflozin, and rapamycin are the riskiest ones in your stack in terms of rare but freaky side effects and in order of expected efficacy from lowest to highest. Priapism for tadalafil, genital infections for empagliflozin, and overall infections for rapamycin. Out of those 3 I’d guess rapamycin has the better risk vs. reward at a relatively moderate dose of 5 or 6 mg one time a week.

4 Likes
#12

At almost 67 years… my PSA is .78

Good choice for clearing cholesterol in blood too.

20241214_001007
20241214_0010071920×853 102 KB

4 Likes
#13

So far so good on tadalafil, been taking it for years, never had priapism. So far so good on no genital infections (I keep good hygiene, and more of an issue for women afaik). Yeah rapamycin no side effects so far, but only been on it a couple months.

7 Likes
#14

Read from here, it’s something that would require decompression (with permanent side effects). Probably is riskier off-label without ED.

It seems extremely rare to have serious infections: FDA Drug Safety Podcast: FDA warns about rare occurrences of a serious infection of the genital area with SGLT2 inhibitors for diabetes | FDA

But combination of it and rapamycin probably is not as good as one or the other for risk although hard to quantify. I think I overestimated this risk and it’s lower (for serious ones) when used on its own.

2 Likes
#15

As said in the other thread about Q10: I’m not sure ubiquinol is beneficial (could be detrimental).

Multi vit: make sure B6 is not too high. And B9 might lower lifespan later in life.

Other compounds: no opinion or seems OK to me.

3 Likes
#16

Yeah I have the same concern about ubiquinol, there are just so many conflicting studies. My rationale is that I take a moderate dose statin and do not want my coq10 depleted. I need to do more reading on the possible detrimental effects as far as statin/non-statin users.

The way I see it now is, on 20mg atorvastatin and 100mg coq10 I get no myopathy. I could eliminate the coq10 and see how the myopathy is. Not sure I want to bother with that, but will consider the experiment.

1 Like
#17

There’s not even evidence in statin users for muscle pain. You could also stop ubiquinol, lower atorvastatin to 10 mg and increase ezetimibe to the normal 10 mg.

5 Likes
#18
  1. I’m not convinced of low dose rapamycin. 20-30mg once every two weeks or monthly could potentially be better.
  2. Solid choice
  3. Also good and more affordable than 10mg
  4. Solid choice
  5. Solid choice
  6. Aren’t you worried about too low blood sugar levels if you combine it with empa?
  7. Fine if you don’t experience side effects
  8. Potentially high dose
  9. I’d rather use low dose ubiquinol to compensate for atorvastatin
  10. More magnesium
  11. ?
  12. How much raw choline does this contain?
  13. Do you use it for sleep?
  14. Solid choice but make sure it doesn’t contain vitamin A or E.
  15. Potentially too much vitamin A
  16. Could be a bit too much omega 3
  17. Okay dose
  18. Good dose, could be higher
  19. Good dose
  20. Okay doe
  21. I’d cycle NAC

Potentially missing astaxanthin, zeaxanthin, lutein, a 5ar inhibitor, hyaluronic acid, collagen and lycope.

10 Likes
#19

I reduced my dose on Fish Oil since the A. Fib linkage came out. I do tons of cardio so I am at risk as it is.

2 Likes
#20

What level of omega 3 are you at now?

#21

.6. I monitor blood sugar pretty closely, not CGM, but frequent finger pricks. I never go below 70.
.8. No side effects and really helps my high normal bp.
.10. Yes I should up this a little
.11. Magnesium L Threonate recommended by Dr. Attia. It more easily crosses into brain.
.13. Yep it seems to help
.16. Possibly too much, was going higher in the hopes of reducing my elevated triglyceride levels

Yes finasteride, collagen, and some of the others I have considered.
Thanks for the comments

3 Likes
#22

Here is mine (39M) with some notes added for context. I get frequent blood work and have a blood pressure monitor at home so I’m not just guessing with this stuff. I got into healthspan/lifespan because I made some poor decisions with my body in the past and it woke me up.

Acarbose (150mg)
Astaxanthin (12mg)
Collagen Peptides (20mg)
Creatine (5g)
DHEA (50mg) - DHEA-S level was low
Empagliflozin (10mg)
Ezetimibe (10mg)
HGH (2iu) - controversial but I like the effects from it and am bullish on the TRIIM trials
Hyaluronic Acid (200mg)
Lithium Orotate (10mg)
Magnesium Glycinate (240mg)
Melatonin (1mg)
Modafinil (100mg) - recently added, makes me feel smarter
Naturelo Multivitamin
Nandrolone (100mg PW) - for joint health
Nattokinase (8000 FU)
Nebivolol (5mg) - to slightly reduce my resting heart rate
Pregnenolone (100mg) - pregnenolone tested low so I take it
Rapamycin (5mg E10D)
Retatrutide (2mg PW)
Rosuvastatin (5mg)
Selegiline (5mg PW)
Taurine (4g)
Telmisartan (40mg)
Testosterone (200mg PW) - anabolic steroid use from age 25 forced me to be on TRT
TMG (1500mg)
Trazadone (150mg) - helps me sleep
Cytomel/T3 (50mcg) - I have poor T4 to T3 conversion (despite a great TSH) and feel awful if I don’t take it. T4 or T4/T3 both failed to make me feel better.
Ubiquinol/CoQ10 (100mg) - @adssx isn’t gonna like this one :shushing_face:

14 Likes
#24

The body only produces <1mg per day in total so you don’t need high doses to replenish it.

#25

I recently switched to dutasteride after being on finasteride for about 2.5 years. I’ve noticed no difference, no side effects. I’d just recommend most people hop straight on dutasteride at this point, the side effect profile is essentially the same as finasteride.

3 Likes
#26

Just for the synovial fluid or are you also shooting for more collagen synthesis or more anabolism on top of the 200 test? Some say it just masks inflammation that should be dealt with by another method.

Sincere question. I don’t have an opinion.

I feel so much better on 2IU of GH but it pushes my IGF-1 into the mid 300s and I don’t know what to think about that long term. My IGF-1 already runs 250ish.

2 Likes
#27

150mg Trazadone is pushing into priapism risk territory. Is there a reason you aren’t using 50 or 100? I’ve never really seen anyone take more than 100 for sleep.

1 Like
#28

I took 150mg for sleep for a long time. No damage.

2 Likes
#29

Using Algae oil for predominant DHA

Algal Oil (Schizochytrium spp.) 1,470 mg :latin_cross:
Total Omega-3 (as TG^) 770 mg :latin_cross:
Docosahexaenoic Acid (DHA) 450 mg :latin_cross:
Eicosapentaenoic Acid (EPA) 140 mg

couple tablespoons of Chia seeds for ALA

Occasional sardines and other fish EPA

Pretty much lowered my EPA (fish oil) since the correlative studies were with Fish Oil

3 Likes