#21

Definitely… that is a lifespan dose not an ED dose.

Once tadalafil (accidentally wrote finasteride) builds up… you don’t need as often. Every third day. The low does builds-up in your system to reach a steady-state plasma concentration within 5 days.

Link: How long does tadalafil last? - Dr Fox.

  • Still effective?: 36–48 hours
    Some men can get good erections for up to 48 hours. This is why tadalafil is sometimes known as ‘the weekend pill’ – you can take it on a Friday night and still make use of it on a Sunday morning!

I take at night before bed with finasteride another drug that builds up with time.

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#22

Did you mean Tadalafil?

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#23

Have you ever heard of someone getting this from Tadalafil? Especially at such a low dose?

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#24

A postmarketing safety surveillance study by Eli Lilly reported the risk of tadalafil-associated priapism as less than 1 in 10,000.1

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#25

Not to be too much of a skeptic, there has to be some wiggle room in terms of what they report, or how they parse out things that “might” not be classified as full “priapism”, so they can remove it from the count. Could the real number be 3 to 5 times higher?

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#26

Something to keep in mind here is that the single dose recommended for taking it once to last a “holiday weekend” type thing is 20mg - four 5mg pills. So I’m wondering how many dudes that experienced priapism were just taking a pill a day vs the four pill “weekender” dose. I’m hoping it’s mostly the latter as I take 5mg a day and really appreciate its affect on my BPH-affected urine flow.

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#27

You did a long period (three years?) of continuous daily use, correct? Did you feel like it was losing effectiveness over time? And did taking two weeks off restore the receptors and make it work better when you restarted?

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#28

Yes, I’ve been on the medication for 3 years.

With no lack of benefit, so I’ve never cycled it, nor has my doctor told me to cycle, because I’m on the low dose of 5 mg daily.

I considered taking a break after the above video. But have since thought no. Keep on the program… daily use.

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There is no evidence to suggest that tadalafil directly down-regulates receptors, specifically in the context of its primary use for ED or BPH. Down-regulation typically refers to a decrease in the number of receptors or their sensitivity on the surface of cells, usually due to prolonged exposure to a stimulus or drug.

Tadalafil acts on the PDE5 enzyme rather than directly on receptors. Over time, the body may develop a certain level of tolerance to drugs that work on receptors, but this is different from receptor down-regulation. In the case of tadalafil, tolerance development appears to be minimal, and its long-term use has not been associated with significant down-regulation or desensitization of receptors.

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#29

I have this problem too and it sucks. I now take 2.5mg daily instead and it’s not nearly as bad, so try dropping the dose. I cut the 5mg tab in half and take it with breakfast

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#30

Keep in mind that this 1 in 10,000 are in people with ED…(the opposite of priapism). Would the number change if the drug is used in 10,000 people with normal erection ?

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#31

Anecdotally, in 30 years in the ER, I’ve only seen 4 or 5 cases of priapism, none related to these medications.

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#32

When I first started daily low dose, I had the stuffy nose side effect. At first I was ready to give up, but thankfully this went away over the first month or two.

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#33

Is daily morning or evening dose better. I have started in the morning to help with blood pressure recently.

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#34

Before you go to bed is best if you’re on 5-ARIs.

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#35

There are non-surgical treatments for priapism. When I as young, I once experienced priapism. It is a long story, but the short version is that for me, a long 10 k run at 100 % effort made Mr curious soft and relaxed. No injection treatment or surgical procedure was needed.

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#36

At what dosage? (20 characters)

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#38

I guess this is a topical delivery “composition”…?

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#39

Aim: The aim of this article is to determine whether tolerance developed to the effects of tadalafil on erectile function (EF) over a 6-month treatment period.

Methods and main outcome measures: Post hoc analysis of data from a multicenter, double-blind, randomized, placebo-controlled, parallel group study was performed. Men (> or =18 years of age) with erectile dysfunction (ED) were randomized to treatment with placebo (N = 47) or 20-mg tadalafil (N = 93) taken as needed for 6 months. This report focuses on efficacy assessed with the Sexual Encounter Profile (SEP) diary (diaries were collected after a 4-week treatment-free run-in period [baseline], and monthly for 6 months), and with the International Index of Erectile Function (IIEF) (administered at baseline, and at 3 and 6 months). RESULTS. The mean per-patient percentage “yes” response on SEP question 3 (SEP3, successful intercourse) was 33 +/- 4% at baseline, 74 +/- 4% after 1 month, and 78 +/- 4% after 6 months of tadalafil treatment. The IIEF EF domain score was 16.2 +/- 0.7 at baseline, 24.3 +/- 0.8 after 3 months, and 24.3 +/- 0.9 after 6 months of tadalafil treatment. In a subgroup of patients who took tadalafil > or =3 times per week (N = 24), the SEP3 score was 87 +/- 4% after 1 month and 93 +/- 3% after 6 months of treatment, and the IIEF EF domain score was 27.3 +/- 0.9 after 3 months and 28.5 +/- 0.4 after 6 months. Of 16 tadalafil-treated patients who discontinued, three cited a lack of efficacy.

Conclusions: Tadalafil treatment significantly improved SEP3 and IIEF EF domain scores. The efficacy of tadalafil, taken as needed, was maintained over a 6-month treatment period in men with ED.

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#40

It’s surprisingly very effective I personally know of someone he developed it for Ed but is using it on face now.

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#41

Interesting… Another compound to our DIY super skin cream… Rapamycin, senolytics, etc.

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