My first post on this forum:
I am looking to make a lotion including Rapamycin based on advice in this long thread.
But as a resident in Norway in Europe I am struggling to find Transcutol or equivalent as a base topical mix. It is too expensive to send Transcutol from the US to Europe unfortunately ca 100USD for shipping
Could someone guide me to how to buy Transcutol or equivalent in Europe, or shipped to Europe for a reasonable cost?
Thank you!
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Hi, here are some tips on finding Transcutol in Europe.
first of all - there are many names to search for:
Here are all the different identifiers / names for transcutol. Googling on the CAS # might be helpful, or any of the other names:
Transcutol has a number of different chemical names/identifiers. Here is a list:
- 2-(2-Ethoxyethoxy)ethanol: Ethoxydiglycol, 3,6-dioxa-1-octanol,
- DEGEE, diethylene glycol monoethyl ether,
- Carbitol,
- Carbitol Cellosolve,
- Transcutol,
- Dioxitol,
- Polysolv DE,
- Dowanal DE
Chemical Identifier: CAS Number 111-90-0
Some sources in NL:
The UK:
off Amazon
https://www.amazon.co.uk/Eastchemlab®Diethylene-glycol-monoethyl-ether-CAS/dp/B08BRL8K36
https://www.guinama.com/ is a place where you can buy Transcutol in Europe, no prescription needed.
Transcutol is available at www.guinama.com in Spain.
Like most things in Spain, they only think in selling to the Spanish market so they require a national ID or residence number in order to make the purchase.
I gave them a call to inquire about a purchase by a European or UK citizen.
This can be done bypassing the automated web and contacting directly with Mrs. Christiana Tilg at ventas@guinama.com
Hopefully this is of use.
Source: DIY Rapamycin Toothpaste and Flossing Paste - #78 by Christian.M
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nac+glycine, paba, vit b complex, D3, n-acetyl l-tyrosine, glutathione, mucuna pruriens
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If the cause is due to melanocyte stem cell interruption during the growth cycles due to stress or illness then the use of photobiomodulation for cellular rejuvenation may reverse the process.
Topical anti-aging compounds that are currently under investigation include photo protectors, such as cinnamidopropyltrimonium chloride and solid lipid nanoparticles as carriers for UV blockers, oral supplementation with l-cystine and l-methionine, and topical melatonin.
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SNK
#547
Couple days ago you said “11th day using GR7 and no changes in hair color”
Fast forward to today and you post a picture that shows not only that your hair has definitely turned black but change is so huge that one can barely tell it is you. Can you explain it? Was the effect only in last couple days ?
Or maybe you dyed it professionally?
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it’s not me. I accidentally found this information on the Internet and decided to share it with you. maybe it will be useful for someone
This is my progress on Gr7 to date. 2 weeks. the color does not change, only black dots appeared at the roots of the hair. you can draw your own conclusions.
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The only benefit I can note from the supplements is the growth of a lot of new hair. And the eyebrows became thicker and darker
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have you seen this post? Man claims his hair is full of pigment again after taking three supplements: * L-Cystein (NAC) * L-Methionin * PABA
https://www.reddit.com/r/tressless/comments/x6ezya/fighting_hair_loss_and_grey_hair/
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DrT
#551
Unfortunately, showing 3 or 4 hairs that are in the process of turning from white to dark is not proof that an intervention is working.
This is how hairs normally change. First, they are fully dark. Then, when the old hair has fallen out and a new one starts, it’s white at first, then reverts to dark. Next cycle, the white portion is longer, maybe 50% before the colour kicks back in. Next cycle, the hair might be 75% white until it darkens. Finally, the whole hair is white. Melanin production and insertion into the shaft has ceased.
This is the process of normal depigmentation of hair.
So, finding a few that have reverted from white to dark means nothing.
2 photos taken months apart under the same conditions that show markedly darker hair in the more recent photo…that could be evidence.
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Thank you for all the guidance on buyinh Transcutol in Europe.
The Amazon-links did no provide available products, and I received no response from the company Guinama.
But I was able to purchase Propylene Glycol from Amzon.co.uk, I will use that as my “base” in the mixture.
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Hello. I have tacrolimus ointment with the following composition: white soft paraffin, mineral oil, propylene carbonate, white wax, paraffin, butylhydroxytoluene (E 321), alpha-tocopherol. Please advise how to properly dissolve it in minoxidil from Kirkland
hamtaro
#554
I’m curious as well. I’m currently a vampire… and would love a bit more melanin protection… but I don’t like what this guy says about how it affects the hair. I don’t want darker hair (unless it darkens the gray hair), and I don’t want my hairline to recede more.
Maybe astaxanthin may be useful. Caretonoids have been known to change skin color after all.
J0hn
#556
Well, it seems to work for salmon and flamingos 
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This is wrong. Nothing you state here refutes what he said. He is entirely correct there is precious little clinical evidence that DHT plays any significant role (let alone a vital one) in adult men. In fact, we have slam dunk, irrefutable evidence that, at least in the role of building and maintaining muscle mass and body composition, it plays NO ROLE WHATSOEVER, as those men who are born with an inability to produce 5AR at all are leaner with more muscle mass.
Similar story with bone density, it’s estrogen, not DHT that is primarily responsible for mechanotransduction and the resulting activation of osteoblasts, and estrogen increases in 5AR inhibitors. If anything, finasteride and dutasteride will increase your bone density.
Saying that “most people with a clear understanding of endocrinology…advise people to stay away from reducing it” is absolutely not the case, and in fact, the greater your command of the literature, the more confident you are in the efficacy of these drugs, which I remind you has been verified in millions of men over decades. Your unsubstantiated scaremongering simply has no chance against millions of patient hours of info on these medications.
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DHT based does not in any way suggest that it is the same as DHT. In the same way, DHT itself is testosterone based, but the effects of the two hormones are drastically different. Similarly, if you know anything about DHT based steroids, you will know that there are drastic differences between the compounds. Anavar, masteron, and anadrol are all DHT based, and they all act VERY differently. Masteron won’t build any muscle at all, anadrol can build a ton of muscle (and also cause breast development).
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@Ryan_McCarter I am very interested in bone health. Estrogen is a key to bone health you say. Is this true for men also?
This is my understanding. I’ve seen this in several places, and I also recall Peter Attia casually stating in one or another podcast episodes that “estrogen is the primary mediator of the mechanotransduction that drives the response of bone to weight bearing exercise,” (paraphrased) although I don’t remember which episode. So that appears to be his understanding as well.
“Bone mass and strength is mediated by appropriate weight bearing, and it is clear that bone tissue senses and adopts mechanical stresses. However, the precise molecular mechanisms in mechanotransduction remain elusive. Recently, several studies clarified that estrogen receptor alpha (ERalpha) plays important role in mechanotransduction. For example, the lifespan of osteocytes is prolonged by mechanical loading through ERalpha action, which is produced by the plentiful expression of ERalpha in osteocytes.”
“Estrogens are key regulators of bone turnover in both females and males. These hormones play a major role in longitudinal and width growth throughout puberty as well as in the regulation of bone turnover.”
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tfl.phd
#561
The safety of 5AR blockers has not been sudied long term in the current population of people taking it for hair loss which is 20-40 year olds. You only can say that it was safe for those 45-65 years old and older taking it for BPH, which was the age group of those in the safety research. Rarely do drs now prescribe finasteride for BPH as there are more effective solutions since 1996. When you show me the long term safety studies on those of finasteride who are in their 20’s and 30’s taking it for hair loss, then I will agree with you. But as of now that is not the case.
I am not completely against 5AR blockers, some people like myself had side effects. In that case it is stupid to continue it. So I did RU-58841 instead with other topical antiandrogens.
Do what you want with yourself just let people analyze the pros and cons for themselves. It’s an individual choice in the end of the day and you cannot tell me or many others that we didn’t experience side effects from 5AR blockers when clearly I discontinued the drug due to intolerable ED, anhedonia etc… I don’t know if you ever took finasteride and then received a hair trasplant, but unless you’ve done it youself then how can you possibly compare if taking a pill for the rest your life vs a 1 or 2 time lifetime procedure is better?
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Finasteride has been on the market for many decades and it was approved for hairloss at about the same time it was approved for BPH. People back then did not bald any later than men do nowadays.
So I did RU-58841 instead with other topical antiandrogens.
You took a topical, research-only anti-androgen which got abandoned by Kintor and are worried about the safety of finasteride?
It’s an individual choice in the end of the day and you cannot tell me or many others that we didn’t experience side effects from 5AR blockers when clearly I discontinued the drug due to intolerable ED, anhedonia etc…
The risk of that occuring is only 2% over placebo and goes away with continued use or within 3 months upon cessation in every clinical study ever done.
but unless you’ve done it youself then how can you possibly compare if taking a pill for the rest your life vs a 1 or 2 time lifetime procedure is better?
You don’t have infinite donor hair and your donor hair may also be affected by DHT.
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