#73

That’s probably reverse causation.

2 Likes
#74

Yes, the old saying “correlation does not equal causation” always needs to be remembered.

#75

https://www.guinama.com/ is a place where you can buy Transcutol in Europe, no prescription needed.

3 Likes
#76

Hi Christian

thank you for the hint, but there a NIF/CIF number is required for registration, which I do not have…

#77

Transcutol is a pretty cool molecule, but I do wonder if plain old ethanol is good enough to do the trick of dissolving rapamycin for these purposes.

#78

Hi all,
Transcutol is available at www.guinama.com in Spain.
Like most things in Spain, they only think in selling to the Spanish market so they require a national ID or residence number in order to make the purchase.
I gave them a call to inquire about a purchase by a European or UK citizen.
This can be done bypassing the automated web and contacting directly with Mrs. Christiana Tilg at ventas@guinama.com
Hopefully this is of use.

6 Likes
Reverse Gray Hair, Hair Repigmentation
#79

Hello all,
Has anyone any follow up data on their DIY Rapa paste or mouthwash?
Very curious whether there are any positive results on this

2 Likes
#80

I got an excessive amount of mouth sores on it, so took a break. I’m going to make a second batch and try again, see if I have the same result.

#81

great info. Have you seen some progress in gum health?

1 Like
#82

what progress you are seeing after using the rapamycin dental paste?

1 Like
#83

so 6 months in, what improvement you have experienced in dental health?

1 Like
#84

Other than my dentist raving about how my teeth always look so good (to the hygienist) on my last visit, nothing to report. This is new, however. Previously only my hygienist was complementary. I used to get ominous comments from my dentist about receding gum lines. It may be better flossing that is at work here rather than rapamycin.

1 Like
#85

Why not a simple MCT | Rapamycin toothpaste?
Possible formulation:

  • 1/4 cup MCT oil
  • Rapamycin disolved in Transcutol (as per RapAdmin suggestions)
  • 1 -1 1/2 tablespoons baking soda
  • 7-15 drops of peppermint or lemon essential oil

MCT has significant anti-bacterial and anti-fungal properties (and more of them than coconut oil). It may additionally support a balanced oral microbiome.

Baking soda has lower abrasion that hydrated silica, e.g:

Mohs Hardness of materials (an ordinal scale):

  • Tooth enamel = 5
  • Tooth dentin/root = 3
  • Baking soda = 2.5
  • Hydrated silica in toothpaste = 5-7

The American Dental Association has published their RDA (Relative Dentin Abrasivity) to measure the abrasiveness of various toothpastes. The RDA abrasiveness categories are:

  • Low 4-70 (plain water is 4. Baking soda is 7.)
  • Medium 70-100
  • High 100-150
  • Harmful 150-250

The FDA limits abrasiveness to a maximum of RDA 200. The RDA of Arm & Hammer baking soda is only 7. Whereas the most typical tooth paste will be in the 70-100 range with many far above that. THAT is how gentle baking soda is, as far as abrasion to your teeth.

This seems pretty viable.

Thoughts?

4 Likes
#86

Extending some of my earlier thoughts and digging through my biohacking notes, I came across Allerpops (note I have no connection to the company, but I have tried the things).

The founder, Cliff Han’s story, (see: https://allerpops.com/about/) reads like pure biohacking.

Han developed allergies. Conventional treatments didn’t help. As a scientist he tried to figure it out for himself. Han eventually conjectured that an imbalance of the oral microbiome made one susceptible to allergens.

From that conjecture, he developed a prebiotic formula (delivered as a lollipop) that he thought would rebalance the oral microbiome. He claims it worked for him and others.
I tried it a few times and subjectively had some improvement.

The idea of rebalancing the oral microbiome resonates with me, because I spent a great deal of thought and energy into rebalancing my gut microbiome with very significant success (but that’s another story).

Then I came across (in this thread) a mention of Michael Lustgaten’s oral microbiome hacking efforts. (I like his general thinking, but he introduces too many changing variables into each of his “experiments”)

It strikes me that oral health has a great deal to do with a balanced oral microbiome.

Conjecture:

A properly balanced oral microbiome will do most of the work to maintain oral health.

I think Han and Lustgaten may each have part of the solution.

That said, I find many of Han’s key ingredients worrying:

ORGANIC CANE SUGAR, HONEY, HIGH MALTOSE NON-GMO CORN SYRUP, TREHALOSE, LACTOSE, ARGININE, CALCIUM LACTATE GLUCONATE, COCOA POWDER, HYDROGENATED COCONUT OIL, CARRAGEENAN, MANNOSE, INULIN, SALT, CINNAMON, VANILLA EXTRACT.

But Han had another idea… knock down the bad microbiome before introducing prebiotics. Before using his Allerpops Han originally suggested:

  • Scrub your tongue with a tongue scraper or wet washcloth until most of the white/yellow biofilm on the top is gone. Caution: brushing too far back may lead to a gag reflex.
  • Gargle hot (optimal 120 ºF) water for about 10-20 seconds. Spit out and repeat gargling for three minutes. Your tongue should be red without any biofilm. If it isn’t, scrub it with the wet washcloth and gargle one more time.

I used a similar strategy to rebalance my gut microbiome - knock down the bad stuff then introduce prebiotics (e.g., resistant starch).

Could gargling and rinsing with hot water prior to brushing and or flossing with a rapamycin tooth paste amplify the good it can do?

Knocking down the unbalanced microbiome might also make the things Michael Lustgaten has tried to reduce bad stuff and increase good stuff more effective.

Rapamycin has a normalizing affect on the gut microbiome. Someone in this thread suggests it might do the same with the oral microbiome.

MCT oil has a positive affect on the gut microbiome.
Lustgaten, identified peppermint oil as useful.
Baking soda helps shift the Ph.

Add some Xylitol to the tooth|flossing paste or mouthwash?

Just some thoughts.

One more thing, I think Han’s idea of rinsing/gargling with 120 degree water creates an environment for prebiotics to flourish in feeding one’s heathy microbiome.

3 Likes
#87

Thanks. This is an area of interest for me related to improving nitric oxide, although there may be additional benefits to be had on oral health.

#88

I know that commercial mouthwashes and any toothpaste with fluoride is terrible for nitric oxide.

#90

There are specialty products for people who want to build and maintain a healthy oral biome. The experts say a healthy oral biome will keep the bad bugs from getting out of control (cavities, periodontal disease, etc).

#91

I don’t think avoiding flouride toothpaste is a good idea at all. Preferably you’d even choose Stannous fluoride toothpaste which is even better. It’s sold as Crest/Oral-B toothpaste.

1 Like
#92

Avoiding fluoride in your toothpaste is only a good thing if you care about nitric oxide. It is otherwise useful. But I am not prone to cavities.

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#93

What is your reasoning or evidence for fluoride toothpaste being a bad idea for nitric oxide? I know nitrate reducing bacteria in the mouth produce NO from dietary nitrate which is why a healthy microbiome in the mouth can help produce NO. I have never heard of evidence of fluoride influencing this.

1 Like