I continue with Taurine. I find Taurine performance enhancing + there are a huge bulk of science indicating that Taurine is beneficial for many orrgansystems in humans. Nobody know if it increases lifespan in humans. But the effect of Taurine on mitochondria alone, is a good enough reason for me to continue taking it. + there is a very limited downside.
“Mitochondrial dysfunction, along with oxidative stress, is a key hallmark of various pathologies, such as aging [1,2], cardiovascular diseases [3,4], mitochondrial diseases [5,6], metabolic syndrome [7,8], cancer [9,10] and neurological disorders, such as neurodegenerative diseases [11,12] and neurodevelopmental disorders [13,14]. Often, antioxidant therapy, such as coenzyme Q [15], mitoQ [16,17], vitamin E [18], gingko biloba extracts [19], ebselen [20], creatine [21], lipoic acid [22], melatonin [23,24] and l-arginine [25,26], provide some protections, potentially by improving the mitochondrial function and reducing oxidative stress in these diseases. Recently, taurine, a sulfur-containing amino acid, has been approved in Japan in treating stroke-like episodes in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), which is a mitochondrial disease [27,28]. Indeed, the use of taurine dates back to 1985, as taurine was first used to treat patients with congestive heart failure in Japan [29,30]. In addition, taurine supplementation has been shown to improve the exercise capacity of patients with heart failure [31], which is likely due to improvement of the myocardial energy production. Although taurine was first identified in the 1800s [32], the mitochondrial actions of taurine still remain unclear and underappreciated. This review, therefore, will provide an overview of the significant role of taurine in the maintenance of mitochondrial function. Clinical studies using taurine therapy in mitochondria-targeted pathologies will also be discussed.”
