#891

You need to write a book titled “The Charlie Munger / Warren Buffet Longevity Diet” (and include the McDonald’s protocol :wink:

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#892

I wish there was a way to eat food all day and not get fat.

#893

High dose flozin and you might be peeing out the twinkies and candy bars. Super power.

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#894

My lifts would suffer.

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#895

This vibrating diet pill may trick the stomach into feeling full

The capsule—reported today in Science Advances—slashes food intake in pigs without causing obvious side effects. Scientists now hope to develop it into an obesity treatment for humans.

“It’s a credible and ingenious approach,” says neurobiologist Guillaume de Lartigue of the Monell Chemical Senses Center, who wasn’t connected to the study. “The data look very convincing.” Still, other experts question whether the pill can be turned into a practical weight loss therapy.

https://www.science.org/content/article/vibrating-diet-pill-may-trick-stomach-feeling-full

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#896

14 posts were merged into an existing topic: Bryan Johnson’s Anti-aging Skincare Routine

#899

Why not just use Mexican Jumping Beans?

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#900

I do think Bryan has a point about eating most meals early on the day, his experience and many others is that it improves sleep. I did look at the scientific literature awhile ago and it seems very good to set the circadian rhythm as well.

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#901

Curious @AnUser - what’s is your current longevity protocols + what are you thinking it might become over the medium term?

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#902

I only take rosuvastatin 5 mg. I literally do not do anything else - no exercise, no sleep hygiene, nothing. I have the hobo protocol of the longevity world right now. After my blood test soon I’ll add 5 mg ezetimibe and then retest. If apoB is not optimal then I dunno what to try to add with it.

I am going to try different things but this is my first priority, I do think my longevity protocol development is on an exponential curve so it is all going very slowly right now. Generally I think I will optimize different things for wellbeing, including diet, exercise etc, and drugs, it’s of course good if they cross on a venn diagram. I did make a meal I liked recently that did score higher points for the Med diet. Exercise will be to optimize wellbeing. Of course is there is a longevity drug that doesn’t affect wellbeing that is fine too. But it does affect my choice of SGLT2i if I do likely try one in the future, for example.

image

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#903

Thanks for sharing.

I think you should consider seeing exercise and sleep as at the same level of importance and impact and risks avoidance as optimizing Apo B.

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#904

I can’t since I don’t believe it’s true.

#905

What don’t you believe is true?

#906

That optimizing exercise and sleep is of the same importance and impact as optimizing apoB.

#907

Interesting - it may be difficult to quantify, but my feeling is that it’s up there giving how multifaceted impacts both provide across cancer, cardiovascular health, metabolic health and neurological health.

Think on exceeding we can debate at what point it becomes too much, but that zero is massively worse than a little does seem to have a lot of support.

Anyone no need to debate - I was just saying it out of caring for you.

#908

I think that the data on sleep and exercise suggest they are important (specifically for exercise and quality of life / activities you can do later in life), the data also suggests that if you’re basically getting reasonable levels of both (e.g. 7 to 8 hours sleep, and 30 minutes a day of activity) they are not going to be limits on your life. Whereas an unmeasured and untracked APOB that is higher than ideal will literally kill you, and in fact does for most of Americans. I think the model that @AnUser is looking at is someone like Charlie Munger and Warren Buffet, who never exercise (from the looks of it), eat at McDonalds frequently, probably get reasonable sleep, and live well into their 90s without any issues.

I would argue that these two reference points (both billionaires) probably also had excellent concierge doctors and the best of class medical care , but hard to prove.

And of course, if at 90 years old you only want to shuffle between the bedroom of your mansion and the home office so you can Zoom with friends and employees, thats your choice :wink:

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#909

I still think it’s important, but for other reasons, like wellbeing. But I can’t use the Dark Arts to trick myself into believing it has the same impact on longevity as apoB, I’d only use that rarely. I will do an exercise schedule that will optimize mood, I think the “massive amounts of Zone 2 exercise for longevity” seems a bit iffy.

Also if I exercise a lot I have to eat a lot of food, that must be whole grains and olive oil then. There is some SFA in olive oil, it might increase my apoB.

Yeah I do make sure to sleep enough in general, but that’s just for wellbeing. I will be a wreck if not. Some people have an anti-depressant effect from sleep deprivation though. I don’t drink coffee or use any other stimulants right now. However I don’t optimize it right now - Oura might give a bunch of poor scores. My sleep score for 2023 was 65 “Fair - Something may have disturbed your sleep quality a bit”. Above 70 is good. I had 8h 24 m in bed on average.

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#910

Do you practice any CR?

#911

Nah, I think I am done calculating food with a food scale unless I lose too much weight. I think I’ll just keep it simple. I’ll eat as much as possible but healthy food is the idea, so the more I eat the healthier I become.

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#912

A good data point in favor of the importance of sleep is that if you don’t sleep you die in a few days.
On the other hand you can be a super centenarian with very high levels of APOB.

Ten rats were subjected to total sleep deprivation (TSD) by the disk apparatus. All TSD rats died or were sacrificed when death seemed imminent within 11-32 days. No anatomical cause of death was identified.

Even just the deprivation of some sleep stages is enough to die:

Twelve rats were subjected to paradoxical sleep deprivation (PSD) by the disk apparatus. All PSD rats died or were sacrificed when death seemed imminent within 16-54 days. No anatomical cause of death was identified.

Looks like NREM sleep deprivation only kills a little bit more slowly:

The disk apparatus was used to deprive six rats of the portion of non-rapid eye movement (NREM) sleep with high electroencephalogram (EEG) amplitude (HS2). All HS2 deprived (HS2D) rats died or were sacrificed when death seemed imminent within 23 to 66 days. No anatomical cause of death was identified.

Here is a very recent paper (Jan 2024) presenting findings on the mechanism which was previously unknown:
A perfect storm: sleep loss causes systemic inflammation and death

they found that 4 days of TSD induces elevation of several cytokines, multi-organ dysfunction, and death. They refer to the observed elevation in cytokines as a “cytokine storm”. Cytokine storms have received increased attention recently due to their roles in organ dysfunction caused by acute COVID-19 infection.

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