#588

I think chrysin is a promising supplement. At 83 my goal is to preserve as much brain function as possible. So far I feel subjectively superior in brain function to Biden or Trump. Perhaps a little piperine would improve the bioavailability

image
image1920×1245 112 KB

“Sci-Hub | Chrysin: Pharmacological and therapeutic properties. Life Sciences, 235, 116797 | 10.1016/j.lfs.2019.116797”

4 Likes
#589

Are you already on PQQ, creatine and TMG?

#590

I am not currently taking PQQ because I eat a lot of blueberries.
I currently take both creatine and TMG.

2 Likes
#591

It is recommended by some cancer doctors, not with meals. A teaspoon three times a day (not around meal time). Cancer has a sensor on the cell which measures ph and helps it decide whether to migrate or metastacize and sodium messes it up. They say a tablespoon of apple cider vinegar with the teaspoon of baking soda in a cup of water is supposed to do the same thing and the taste isn’t so bad and this is something talked about by Chris Masterjohn which is supposed to put you into ketosis because of the vinegar? I can find that reference if you want, the chemistry is over my head. I’ve done it a few times.

3 Likes
#592

Dr. Brad’s top 9 supplements:

3 for muscles:

  1. Creatine
  2. Protein (whey)
  3. TMG

Others:
4. Multivitamin
5. Omega-3s
6. Psyllium Husk (NOW brand)
7. Collagen
8. Hyaluronic Acid
9. Melatonin

3 Likes
#594

Protein:

Unfortunately, there is no way that I can easily reach the maximum effective dose of 128 grams of protein, which is the maximum effect dose for my body weight which is 80 kilos. (maybe higher because of my age)

“How to get 128 grams of protein a day?
Include high-quality sources of protein in each of your meals, like lean meats, fish, eggs, quinoa, tofu, cottage cheese, or low-fat milk. To realistically consume 120 g of protein a day, try to split your goal into 5 meals (24 g each), or 3 meals (24 g each) with 4 smaller snacks (12 g each).”

That’s why gym rat bodybuilders are always eating so much protein. Even with whey supplementation, I find it hard to reach that goal.

But, I will try to eat that much protein daily for a few months and see how it affects my muscle mass.
At 83 I am a “hard gainer” so I don’t expect much, so who knows?
BTW: I am personally convinced that rapamycin preserves muscle mass and delays sarcopenia.

N=1, “Safety of high dose melatonin”. I have been taking high-dose melatonin for over 40 years with nothing but good results in my opinion.

7 Likes
#595

Quark and skyr are ideal sources for protein and calcium.

2 Likes
#596

None of my local grocers carry quark but they do carry low-fat cottage cheese.
One cup of low-fat cottage cheese contains 28 grams of protein and 163 calories.

1 Like
#597

NMN and Urolithin A quality testing (no brands mentioned)…mostly bad news.

IMG_6953
IMG_69531920×771 78.1 KB

3 Likes
#598

Here is a presentation based on that research. Starting at 8 min 10 sec.

2 Likes
#599

Dang, I’m not a doctor but have never used these three and I have no urge whatsoever to use them. No wonder doctors got burned then.

1 Like
#600

OUCH on this one. NMN I’m still using because I had bought loads of it a while back and still have some left, otherwise I’d switch the cheaper form of B3 Niacinamide as i tend to feel same positives as with NMN. The Urolithin A though just started using last week (from suggestions in these boards). Oh well in couple weeks there will be another study saying Urolithin A is a wonder supplement.

1 Like
#601

For those of you who follow Physionic on YouTube.
He finally got his Ph.D.
He critiques supplements and their claims by reviewing and critiquing studies and papers.

8 Likes
#602

I have taken creatine monohydrate powder in my morning coffee for quite some time because it was easily dissolvable and added no taste I could detect. This was probably a waste of money.
It turns out that it is not easily absorbed by the body when taken with coffee.

I will be switching to creatine nitrate because it is more absorbable by the body when taken with coffee than the monohydrate form. I am satisfied with my muscle mass and no noticeable sarcopenia. At this stage, I am more concerned about brain functioning.

It may also be better for cognitive functions.
“Creatine nitrate and caffeine that were co-ingested significantly enhanced cognitive function, as indicated by improved scores in the Stroop Word–Color Interference test (p = 0.04; effect size = 0.163). Co-ingestion was more effective than caffeine alone in enhancing cognitive performance.”

“The co-ingestion of creatine nitrate and caffeine improved cognitive function, particularly in cognitive interference tasks, without altering short-term exercise performance.”

The study gives a mixed report on the effect of creatine nitrate on exercise and muscle.

“Earlier studies reported that creatine nitrate supplementation increased circulation and muscle creatine levels from 5 to 28 days [20,21] and improved body composition and strength performance as much as creatine monohydrate during 28 days [21]. Moreover, Dalton et al. 2017 reported that 3 and 6 g creatine nitrate over five days improved one-repetition maximum (1RM) and muscular endurance bench press performance at 70% of 1RM without an ergogenic effect during a 4 km time trial performance [22]. Creatine nitrate also seems safe when ingested at 1 to 6 g/day doses for up to 28 days [20,21,22].”

As far as I can find there is little difference in muscle performance at least in the way I was taking creatine monohydrate.

I can’t find any definitive studies that prove creatine monohydrate is not sufficiently absorbed when taken with coffee.

Creatine nitrate is a newer form with higher water solubility, which may lead to better absorption and utilization by the body.

Some research suggests that the nitrate group in creatine nitrate may enhance its solubility and absorption compared to creatine monohydrate.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10974193/

10 Likes
#603

Can you elaborate what you’ve done to reduce your Uric acid level? I’ve had gout attacks and have made dietary changes to reduce my Uric acid with some success. I’m always looking for more ideas.

#604

My own urate has varied and I think the kidneys have a limited ability to remove substances from blood. This is probably increased by clearing more water although I have not checked this. However, if you have a renal friendly diet I would not be surprised if urate goes down as a result. Obviously urate can be increased through the metabolism, but the remaining balance will depend upon the ability to clear it.

What are your creatinine and Cystatin C values?

1 Like
#605

I thought it was a matter of just eliminating fructose.

1 Like
#606

I measure my Uric acid weekly with an UASure blood test (reasonable price). I’ve been aiming for under 5.5 mg/dL which is noted as being the level at which your body can start reducing the uric crystals that drive gout. I’ve done fairly well, sometimes being in the 4.x level, but can not stay consistently under 5.5. The various tables showing purine amounts (which drive uric acid) in foods are incomplete and sometimes counter intuitive. So … I’m always looking for what has worked for others. I have started drinking more water and monitoring my protein intake, minimizing red meat.

BTW, my creatinine level is 1.08 mg/dL. I have not measured my Cystatin C.

FWIW: UASure test for Uric Acid - https://www.uasure.com/

1 Like
#607

5.5mg/dL is 327 mcmol/L and 1.08 mg/dL is 95 mcmol/L.

I think you can probably get down under 5 if your kidneys have not got too much work to do.

1 Like
#608

I take Losartan for high blood pressure and it has a common side effect of lowering Uric acid levels by 30% or more. In my case it dropped to 3.0 from 4.2, which is below the recommended range (uric acid also has beneficial effects as an anti oxident : it is the primary anti oxident circulating in the blood at all times), and I tried to convice my doctor to switch me to Telmisartan, but no luck.

Note that my kidneys are slighly weak : my creatinine level is typically 1.20 and the only reason my eGFR is still 65 is that it assumes as a male I must be well muscled : I am actually sedentary and my wife who gardens has more muscles than me. Even though her createnine level is also 1.20 her eGFR is 43, so she gets treated for CKD!

2 Likes