Metformin affects your HBA1C which can be affected by Rapamycin. Acarbose also helps. I am convinced that 500 mg of Metformin is beneficial, but studies show that higher doses like 2 g daily become detrimental. If your body doesn’t need the extra 500 mg for glucose control, it doesn’t seem necessary.
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Thx for the info. How do we know we are boron deficit? I’m taking it to help with the joint pain. Just 3mg each day.
As for taurine I consume a lot of red meat… That is why I didn’t increase it. Would I get the benefit to raise it to 2g still?
What is SGLT2i? Like Jardiance? Isn’t that a substitute for metformin or do we take it together?
Thank you for your suggestions.
I’ve changed my mind on Boron (Thanks @Neo ). 3 mg sounds great. I’m going to try it as well.
According to the Taurine guide, you should supplement 1 g for every decade you’ve lived, so a 40-49 yo should take 5 g. It’s a rule of thumb based on dosing conversions based on the famous mouse study.
Jardiance is an SGLT2I. It’s great for removing uric acid, protecting kidneys, losing weight, reducing HBA1C, protecting your brain and heart, etc… They’re wonderful. A low dose 10 mg is very inexpensive from India. I buy a 25 mg and split it in half as they are OK to split.
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Neo
#539
I understand those general things, I’m asking something different: if you are taking into account that the context has a massive Rapa dosing and whether
- There is risk of rebound effect
- You think that rebound effects cannot be helped by Metformin
And asking if (1) or (2) are yes and no, do you think higher metformin vs lower metformin would make a difference in (2)
I would say yes and yes. We know there can be a rebound effect, and we know Metformin counters a lot of the detrimental effects of Rapamycin so as long as I take Rapamycin, I will take Metformin. I’m also teetering on the edge of prediabetes so there’s that as well. (5.4 HBA1C with Metformin, 5.7 without). However going from 500 mg to 1 g daily didn’t move the needle for me.
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Neo
#541
Are you in the US, think a lot, if not most of the population is, see this post and other info in the same thread: Supplemental boron (esp for the bones)? - #4 by Neo
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I have been taking 3mg boron daily for a few years because of the argument that it prevents arthritis and background information on this. I had a hair test where boron was OK, but I have not done a blood test.
It strikes me that a small amount of boron is a good thing, but I have not got any anecdotal benefits that I can point to.
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Neo
#543
Thanks. And you have not stopped taking it?
Beth
#544
I have a lot to catch up on! Should I also consider taurine and boron? I need to be spoon fed 
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Neo
#545
I’m not sure. Think each decision needs to be well thought through in the context of the individual and their situation, bloodwork, goals, risk/reward tolerance and taking into account their other supplements and medicines.
Low dose boron is probably quite benign from a risk perspective. Taurine I know less about.
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I put some in my supplement boxes this morning and have done so for a number of years. I can tell you precisely if it matters. But it would need to look up my records.
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Tim
#547
@ng0rge, @RobTuck, @DeStrider, @Neo, et. al.
A quick review of the literature suggests that, compared to metformin, berberine has a more positive impact on the kidneys, especially if kidney function is impaired. Metformin is contraindicated for patients with a GFR lower than 45. Berberine, on the other hand, is said to “ameliorate” kidney disease by regulating nephrotoxins in the gut.
https://www.sciencedirect.com/science/article/pii/S2211383522005184
I’m also waving a yellow flag on boron. There are cases of boron in the water supply that is toxic at low doses. The warning applies especially, @medaura, to the neonatal period.
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Neo
#548
You are talking about boric acid (banned in some US states and many parts of the world)
That is different the form of boron called boron that we get from natural foods or in FDA “ok’d” supplements.
Metformin is contraindicated for patients with a GFR lower than 45. Berberine, on the other hand, is said to “ameliorate” kidney disease by regulating nephrotoxins in the gut.
Not sure if above is correct or not. But do note that supplements tend to not have “contraindications” - so the comparison of a FDA/EMA approved medicine (metformin) and a supplement (berberine) could have issues of not being apples to apples
(Tagging @Curious @Beth - so you don’t miss these clarifications/comments)
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I have not checked but i think the big issue is dose. I think supplements are often in the form of boric acid or get changed to it.
There are problema with higher dose boron.
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Tim
#550
@Neo
You are correct. Boron “is not considered poisonous to animals.”
@John_Hemming
And you are correct. “Boron in high doses can upset the body’s metabolism.”
One of the most interesting things about boron is its many applications.
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Would you say that Resveratrol and Fisetin will be good for days that the rapamycin is not as active… i.e. after day 3 of the fortnightly dose or just give them a miss. I got them from David Sinclair’s regiment. Tomorrow I will start my fortnightly dose of rapamycin and see how it behaves with blood test after 24 hours and after 10 days.
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Resveratrol is supposed to compliment Rapamycin, so I would take 100-150 mg of Resveratrol on the day of Rapamycin dosing and then every other day after that. I take my Resveratrol on Saturday, Monday and Wednesday.
If I didn’t have a lifetime supply of Resveratrol, I probably wouldn’t be using it though.
As for Fisetin, I don’t bother with it as I believe that Rapamycin and Taurine provide the same but larger benefit. So Fisetin is probably net neutral for me.
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From a mechanistic basis, however, Fisetin is an HDAC inhibitor whereas neither Rapamycin nor Taurine are. Oddly enough Resveratrol is an HDAC inhibitor. (I don’t like it because it is a Cox-1 inhibitor).
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@John_Hemming What are your thoughts on anti-inflammatories in general. It seems wrong to lower acute inflammation from an injury or an infection or even a workout. So what’s the use case that makes sense?
AnUser
#555
My HRV has suddenly started increasing after starting these supplements, and ezetimibe a few days ago, what might it be?
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