Same. I’ve used several brands of creatine monohydrate powder over the years. They all taste like nothing. Dump into water, a protein shake, or a smoothie, or sometimes straight into my mouth and chase with a liquid.
2 Likes
Not yet. I’m still on my same 1kg bag. I cant remember the brand offhand (common Amazon brand: bulk Naturals maybe?) but I’ll send the image when i get back home. I have another unopened bag so maybe i’ll try that one.
I worked in chemisty/biochem labs for seven years in college /grad school and you get used to subtle cues about what chemicals you’re using. Bitter taste is noticeable to me. I’ve also always enjoyed wines (the tastes, not just the effects — I must sound like the least fun person to hang out with) so maybe I have a sensitive taste sense or just practice?. Maybe youth but who knows: 53 is young fir 83 but maybe not so much overall.
The “bitter taste” was in a general article about creatinine so it must be somewhat common.
Neo
#511
Would def try some other high quality one and see if you still feel the same taste (and if so unfortunately throw away your current bags).
1 Like
Stiv
#512
I take 5g of what my friend calls ‘horse tablets’ because they are huge (5 powdery 1g tabs). Easy to swallow though. Maybe I should join the circus as a sword swallower
It’s possible you may have a fake product if it has a horrible taste. It’s not supposed to taste that way. You may want to buy from a reputable seller and compare tastes. If the new bag had a neutral taste, I’d toss the first two bags and complain to Amazon.
Remember that Amazon sells fake stuff too.
1 Like
“Iron supplementation has been shown to positively affect intelligence quotient (IQ) scores and iron-deficiency anemia in the elderly is associated with an increased prevalence of dementia and Alzheimer’s disease.”
Since I have always been prone to anemia and have low iron levels, I have to look at this double-edged sword and pick which side to be on.
A choice between longevity or dementia? I think I will have to supplement with iron.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10746024/
5 Likes
AnUser
#515
I’ve started 1 mg methylcobalamin, 15 mg zinc picolinate, 400 mg DHA and EPA, 2 tsp creapure, and 3000 IU D3.
Anything regular creatine, rather than creapure tastes horrible and chemical.
3 Likes
Bicep
#516
I finished the book on copper by Morley Robbins. He claims people short on Iron should supplement copper. Ceruloplasmin is a copper based enzyme that is used to move around Iron and copper in the body. Iron needs to be dealt with properly and used correctly by the body and ceruloplasmin is necessary for that. There are other important things copper does and he goes through them all, but this really does seem to be important. Around 2 mg bisglycinate seems to be a common dosage.
6 Likes
Another checkmark in the curcumin column.
Background
Curcumin (Curcuma longa) is a well-known medicinal plant that induces autophagy in various model species, helping maintain cellular homeostasis. Its role as a caloric restriction mimetic (CRM) is being investigated. This study explores the potential of curcumin (CUR), as a CRM, to provide neuroprotection in D galactose induced accelerated senescence model of rats through modulation of autophagy. For six weeks, male rats received simultaneous supplementation of D-gal (300 mg/kg b.w., subcutaneously) and CUR (200 mg/kg b.w., oral).
Method and results
The oxidative stress indices, antioxidants, and electron transport chain complexes in brain tissues were measured using standard methods. Reverse transcriptase-polymerase chain reaction (RT-PCR) gene expression analysis was used to evaluate the expression of autophagy, neuroprotection, and aging marker genes. Our results show that curcumin significantly (p ≤ 0.05) enhanced the level of antioxidants and considerably lowered the level of oxidative stress markers. Supplementing with CUR also increased the activity of electron transport chain complexes in the mitochondria of aged brain tissue, demonstrating the antioxidant potential of CUR at the mitochondrial level. CUR was found to upregulate the expression of the aging marker gene (SIRT-1) and the genes associated with autophagy (Beclin-1 and ULK-1), as well as neuroprotection (NSE) in the brain. The expression of IL-6 and TNF-α was downregulated.
Conclusion
Our findings demonstrate that CUR suppresses oxidative damage brought on by aging by modulating autophagy. These findings imply that curcumin might be beneficial for neuroprotection in aging and age-related disorders.
5 Likes
Beth
#518
It’s probably on this site somewhere, but if you would be so kind… has it been discussed if just cooking with tumeric is enough? I know to add some pepper.
2 Likes
There isn’t much curcumin in tumeric spice, unfortunately.
2 Likes
I’ve switched to dihydro-berberine. I can’t say I’ve noticed a difference between berberine and dihydroberberine but I’m taking a lower amount because of the higher bioavailability. My new source might also be higher quality.
This paper from Healthspan is a deep dive on it.
Berberine comes with a long list of reported benefits from gut health to apoB to blood sugar. Now I’ve learned it lowers the senescent cell burden. It’s one of my 10 supplements although I don’t take it with metformin (only taken around rapa) or before exercise.
3 Likes
Can you share your source for dihydroberberine?
1 Like
Metformin increases the lactate concentration during exercise. As far as I know, berberine works the same way? Have you noticed a negative effect when you do endurance training? Or have you measured lactates during training? Or is the half-life so short that it doesn’t affect exercise if you time it right?
1 Like
@tj_long Metformin dramatically increases the perceived effort of exercise. I can believe but have not measured my lactate to prove it but I have felt it very consistently. Peter Attia reported on this effect that he measured on himself.
I believe berberine would have the same effect if I took it before exercise but I avoid it. Berberine is know to up regulate AMPK by interfering with the electron transport chain. I don’t want that while I’m exercising intensely. Perhaps it would be like wearing a backpack filled with rocks while walking (rucking), so useful for increasing the effect of easy exercise.
1 Like
@Curious The Dihydroberberine i use comes from Endurance Products. $0.70/tablet. 1x/day.
“Dihydroberberine SR is a sustained-release dietary supplement featuring GlucoVantage® dihydroberberine, a highly bioavailable form of berberine. Easy-to-swallow 150-mg tablet dissolves over 5 to 7 hours for a slow, steady release of dihydroberberine.”
3 Likes
how many people here have high iron in their system and I wonder if that has any correlation to anything positive other than all the negativity I have heard associatied with high iron? I know my iron level now is about 2x the standard maximum. Used to be 3x, and I have tested negative to hemachromotosis. Is it related to being overweight?
What do you guys think of this daily regiment…
1g calcium
500mg magnesium
20mg melatonin (before bedtime)
1g Astragalus
1.4g Resveratrol
100mg Fesetin
3mg Boron
Ashwagandha 1g
D3 7000 IU
K2 MK4 5mg MK7 600mcg
K1 1.5mg
Taurine 1g
NMN 1g
Metformin 1g
Allopurinol 900mg (for my high uric acid levels)
Acarbose 200mg (with each meal)
Except stated, everything is consumed after first meal of the day, for me, it could be breakfast or late lunch depending on what cycle I am in. I am trying out 18mg rapamycin once a fornight with 1.5L of GFT from next week… (I can’t be bother keeping half a bottle of GFT for 2 weeks… so I think maybe on the day, just finish the entire bottle prior to taking rapamycin)
The half-life in rats of dihydroberberine is ~3 hours. This might translate to a longer half-life in humans as many drugs are metabolized more rapidly in rats. I can’t find any studies about the half-life of dihydroberberine in humans. Perhaps you don’t need an extended release. Are your blood glucose levels high with regular dihydroberberine?
“displaying a half-life (t1/2) of 3.5 1.3 h and a maximum concentration (Cmax) of 2.8 0.5 ng/ml. Interestingly, in rats gavaged with dhBBR, BBR was also present in the plasma, displaying a longer t1/2 (9.6 2.1 h,”
https://sci-hub.se/10.2337/db07-1552
1 Like
