#548

You are talking about boric acid (banned in some US states and many parts of the world)

That is different the form of boron called boron that we get from natural foods or in FDA “ok’d” supplements.

Metformin is contraindicated for patients with a GFR lower than 45. Berberine, on the other hand, is said to “ameliorate” kidney disease by regulating nephrotoxins in the gut.

Not sure if above is correct or not. But do note that supplements tend to not have “contraindications” - so the comparison of a FDA/EMA approved medicine (metformin) and a supplement (berberine) could have issues of not being apples to apples

(Tagging @Curious @Beth - so you don’t miss these clarifications/comments)

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#549

I have not checked but i think the big issue is dose. I think supplements are often in the form of boric acid or get changed to it.

There are problema with higher dose boron.

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#550

@Neo

You are correct. Boron “is not considered poisonous to animals.”

@John_Hemming

And you are correct. “Boron in high doses can upset the body’s metabolism.”

One of the most interesting things about boron is its many applications.

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#551

Would you say that Resveratrol and Fisetin will be good for days that the rapamycin is not as active… i.e. after day 3 of the fortnightly dose or just give them a miss. I got them from David Sinclair’s regiment. Tomorrow I will start my fortnightly dose of rapamycin and see how it behaves with blood test after 24 hours and after 10 days.

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#552

Resveratrol is supposed to compliment Rapamycin, so I would take 100-150 mg of Resveratrol on the day of Rapamycin dosing and then every other day after that. I take my Resveratrol on Saturday, Monday and Wednesday.

If I didn’t have a lifetime supply of Resveratrol, I probably wouldn’t be using it though.

As for Fisetin, I don’t bother with it as I believe that Rapamycin and Taurine provide the same but larger benefit. So Fisetin is probably net neutral for me.

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#553

From a mechanistic basis, however, Fisetin is an HDAC inhibitor whereas neither Rapamycin nor Taurine are. Oddly enough Resveratrol is an HDAC inhibitor. (I don’t like it because it is a Cox-1 inhibitor).

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#554

@John_Hemming What are your thoughts on anti-inflammatories in general. It seems wrong to lower acute inflammation from an injury or an infection or even a workout. So what’s the use case that makes sense?

#555

My HRV has suddenly started increasing after starting these supplements, and ezetimibe a few days ago, what might it be?

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#556

Iron is a two edged sword.

As we age it becomes harmful.

In sum, iron satisfies many of the conditions we might look for in a universally pro-aging substance. It accumulates with age; it is associated with many age-related diseases such as cardiovascular disease, cancer, and Alzheimer’s disease; it catalyzes the formation of cellular junk molecules and helps to prevent their turnover; removal of iron from plasma may be rejuvenating; and people with lower levels of body iron – blood donors – have a lower mortality rate.

Iron is intimately associated with aging, and control of body iron stores may be an important way to extend human lifespan.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544343/

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#557

Nice table of chelators and DMSA isn’t on it and they don’t mention doxycycline. I don’t know what to do about Iron.

A couple places showed in different ways that centenarians have more iron, and that more iron is better for longevity. I can’t think how to search for it now, but this is a deep issue that I wish could be simplified.

#558

I think the word is too broad to have an answer.

#559

The studies that I can find are a mixed bag. I don’t think that your iron levels matter that much unless they are too high or so low that you have no energy. The light green background of the chart represents the “normal range” So it looks like the best area to be in is in the slightly below-average “normal” range. The chart represents 6 different studies.

If your iron levels are low you will feel lethargic. If you feel fine your iron levels are probably not low.

“Iron deficiency can be detrimental: While excessively high iron levels are harmful, iron deficiency can also be a concern in older adults, leading to anemia and fatigue.”

A key takeaway from the studies is that you need higher iron levels to preserve “functional status”.

"Iron levels were in the normal range in both groups with significantly higher levels in groups with preserved functional status, p = 0.044."

Sorry, I think this reference has been posted before. It is a good look at some of the biomarkers associated with centenarians.

“For total cholesterol and iron, higher levels increased the odds,”

"Higher levels of total cholesterol and iron and lower levels of glucose, creatinine, uric acid, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, lactate dehydrogenase, and total iron-binding capacity were associated with reaching 100 years."

“Iron serum level was significantly higher in the group with preserved functional status, p = 0.04. Preserved functional status was positively correlated with total protein serum concentration (p = 0.000), albumin concentration (p = 0.000), and iron serum level”

“lower iron status was correlated not only with depressive mood, and cognitive function decline but also with the loss of mobility.”

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Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828184/

Association between Blood Parameters of Nutritional Status and Functional Status in Extreme Longevity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11054152/

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#560

Like I said, it’s a two edged sword.

Understanding which edge you are on should be helpful. Genetic testing is key to optimizing iron as we age.

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#561

I am going to do an @AnUser here: :grin:
No, you are wrong, and if your iron levels are low in old age you will have no energy, you will lose your mobility and you won’t live to see 100. Moderation in all things

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#562

I’m not the one who is wrong :slight_smile: it’s the people who did the studies I referenced who are wrong :slight_smile:

Feel free to let them know :slight_smile:

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#563

I will keep my iron levels in the mid “normal” range. See, you at 100 :grin:

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#564

I usually fast for 2 or 4 days when taking rapamycin. Does that mean I should skip the supplements on those days? What do you guys do? Should I skip the supplements until I start eating again or still keep taking them. My feeling is to skip until I take my first meal.

#565

Since you have the will power to do the fast for that long, i would definitely skip/stop all supplements during that period also. the only thing that might need be taken is something to keep blood sugar in check (i.e. metformin or something else) as it is my understanding RAPA increases it. BTW, take what i say with a grain of salt as I’m not the best in here to give advice on stuff (since I’m as lazy as they come to do the research and I come to conclusions mainly based on a very good dose of common sense and anecdotal evidence). Clearly, there is many MF-rs in these boards that can give a very qualified answer to your question especially with regards to what Rappa may or may not do to lipids or glucose level.

BTW, it just occurred to me that you said you do 2-4 days fasting when you take RAPA? Lets hope that you are not doing 4 days fasting per week because if that is the case you will very soon drop dead :joy::joy:

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#566

No thank you! 100 to me is NOTHING! I either will live to 135 years old, or please God kill me at 80 if I won’t be able to go 135 :joy:. Why 135? well just want to be able to say I lived 3 centuries from 1970 to 2105 lol.

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#567

BTW,

you are missing the BEST that you MUST be taking:

  1. Mucuna puriens - every other day or 3-5 days a week
    2, d- mannose- if uti infection is suspected
  2. Agmatine sulfate
    4.Artemisinin
  3. Vit c and lysine in flu season
  4. Last but MOST important Thymus Glandular support supplement
  5. 5 mg of Cialis for HUGE rock hard Ons and maybe? help with prostate

There you have it!

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