Beth
#97
Thank you for posting this. I have a friend losing his vision from this. I just forwarded this to his wife. Thx again
3 Likes
This might be worth sharing as well. Red light therapy for macular degeneration.
“ Glen Jeffrey is a Professor of Neuroscience in the Faculty of Brain Sciences and Institute of Ophthalmology at the University College London. His research focuses on areas including retinal structure, development and visual areas of the brain as well as comparative evolution of the brain. In the last decade, his work has been centred around public health, looking into cost-effective and safe ways to prevent and even reverse the increasingly common condition macular degeneration. His research has delved into the mechanisms that underpin the aging process and applied these findings to the most energy demanding cells in the body; the retinal cells.
In the last few years, Glen’s lab has been at the forefront of using light to restore the pathological condition of macular degeneration. By using wavelengths of red and near-infrared light at the correct time of day, Glen and his colleagues have shown that these wavelengths of light can help the organelles called mitochondria produce energy more efficiently, offsetting some of the damage caused by aging. This extremely low-cost modality with an unparalleled safety profile may indeed become something that is used widely in the future to prevent and restore metrics of vision in our aging population.”
Follow Glen’s Work Here:
Glen will be a guest on my show soon
6 Likes
Beth
#99
I’ll pass on this now AND that episode when it comes out!! Thank you so very much!!
2 Likes
It appears that Metformin may help with MS as it helps to rebuild your myelin sheaths in your brain.
3 Likes
Neo
#101
We also have this new paper by what seems like a legit group?
From the Longevity Interventional Studies Community & lab of Albert Higgins Chen @YaleMed
Full paper (pre-print):
3 Likes
The Rapamycin doses tested were 3 mg or less in 9 patients only. I guess this shows that higher doses of Rapamycin are needed to show effects.
1 Like
It shows that summaries should list drug and dose.
3 Likes
Neo
#104
And/or that we should skim the actual papers and not just stop with social media 
4 Likes
Exactly. Where’s the proof that they DO work?
1 Like
Neo
#107
@adssx @约瑟夫_拉维尔 This is more a framework and very early application of it - they say so themselves
Having said that
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while I agree with you on CR (and there are other Nature papers that show even mild CR from the NIH funded human clinical trials run by Yale does positively change epigenetic/biological are
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exercise - while it clearly improves healthspan and health state and probably decreases mortality, does not generally have support in the literature extending lifespan or longevity, so that one might actually be as we’d expect based on other geoscience literature
@约瑟夫_拉维尔 - they are actually proposing this type of framework as a way to refine which clocks and when those clocks work and when they don’t - and help the field improve on the clocks
2 Likes
Neo
#108
Anyone having thoughts on the good scores that Metformin got in this paper?
Any learnings from that?
2 Likes
cl-user
#109
I would hypothesize reducing inflammation, as it’s what #1 does and we know inflammation is associated with most chronic diseases, as well as reducing blood glucose.
3 Likes
tj_long
#110
Why wasn’t SGLT2i tested?
Neo
#111
Wasn’t looking for that in my first skim, you can check in the paper here:
@adssx have you seen any epigentic clock data in any studies with SGLTi’s?
1 Like
adssx
#112
2 Likes
Neo
#113
Thx.
They did not use any third generation epi clock:
Second, we selected 4 epigenetic clock phenotypes (n = 34 710) as another set of outcomes to reflect biological age, which is one of the most plausible candidates of phenotypic aging. Epigenetic clocks are biomarkers of aging developed using DNA methylation-level data at different Cytosine-phosphate-Guanine sites (26), which can predict chronological age with strong accuracy and reflect aging. The first generation of epigenetic aging clocks includes HannumAge (27) and Intrinsic HorvathAge (28), and the second generation includes PhenoAge (29) and GrimAge (30). All the genetic associations with these outcomes were obtained from a GWAS of chronological age (31) and epigenetic clocks (32).
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Did not seem to find an epi age signal:
The Effect of SGLT2 Inhibition on Aging and Cognitive Outcomes
For chronological age, SGLT2 inhibition showed an effect on longer father’s attained age [years of life increase, 6.21, 95% confidence interval (CI) 1.27-11.15, P = .01] (Fig. 2A). But we observed little evidence to support the effect of SGLT2 inhibition on mother’s attained age and combined parental attained age (Supplementary Table S2) (36). For biological age, there was little evidence indicating the causality of SGLT2 inhibition on HannumAge, Intrinsic HorvathAge, PhenoAge, and GrimAge (Fig. 2B and Supplementary Table S2) (36) For all MR results, little evidence was observed to support the existence of heterogeneity (P-value of Cochran’s Q statistic >.05).
Neo
#115
Another (long term and continued) proponent for Metformin (who seems to be doing well with his aging results).
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Btw: What are people’s thoughts on AC-11?
On the “top list”
1 Like
