Yeah, muscarinic antagonists (clemastine has some off target muscarinic antagonism) have been shown to increase remyelination in vitro. The fact that the progressive patients saw a worsening might be due to clemastine’s other cholinergic off target effects (from memory only the M3 appears important in remyelination, but clemastine also affects M1 & M2) and progressive patients tend to have less cognitive reserve to compensate for cholinergic effects.
Interesting that above dextromethorphan was mentioned. It’s a known NMDA receptor antagonist. Know what is prescribed off label for MS-associated fatigue? Amantadine, another NMDAr antagonist (though it’s also a dopaminergic agent. It works very well for fatigue, btw)
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Neo
#17
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AnUser
#18
Yes Rhonda Patrick, we know exercise is healthy. It’s groundhog day for like 7 years.
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Neo
#19
@AnUser did you know it helps with myelin sheet growth - I don’t think most people were aware of that…
That is a massive issue in several big diseases like MS (and aging) - and while big biotech investments have gone into it no one has cracked it via any medicine or therapeutic yet
So for people on this specific thread this might be very interesting because of the specific focus of her tweet and the study , not because of that exercise is generally goo
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AnUser
#20
I don’t think it does so it does not inform me on whether to exercise or not (and I think the same would be true for MS patients), lots of good reasons to exercise either way.
Neo
#21
How come?
The paper is in a good journal, research by a very credible team and based on MRI imaging data that tends to be unbiased…
Adding @adssx as this is relevant for Parkinson’s and other neuro
Evidence of association between higher cardiorespiratory fitness and higher cerebral myelination in aging
Mary E Faulkner et al. Proc Natl Acad Sci U S A.2024.
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AnUser
#22
Mechanistic association study.
Neo
#23
That might mean that it makes sense to say - hey we need more info to say that we know that there is a causal relationship
But you said something fundamentally different:
I don’t think it does
That should require some efficient in the other direction?
Otherwise should it not be I “don’t know” or something more like that?
AnUser
#24
Nah, the null hypothesis is that there is no relationship.
Bicep
#25
This might be a good time to put this up:
Since it is the time of year to harvest aronia berries. Most supplements supply between 50 and 300 mg of ursolic acid. A shot glass of aronia juice supplies that and much more. It remyelinates the nerve sheaths. Must not work very well, but that’s the hype.
Unfortunately we can’t get anybody to come and mechanically harvest the 2 acres of aronia we have, so have been just picking them by hand for ourselves. It’s a terrible waste, but such is the state of organic farming. A different set of problems from those of the factory farm for sure. People don’t want to pay.
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DrT
#26
Rosemary is also rich in ursolic acid.
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@Walter_Brown maybe you stated this elsewhere but how would you compare DAV protocol vs dasatinb and quercetin?
Anyone else that has done both, please chime in too.
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Hi @EenDwaze - the only anecdotal report I can give is that the Azythromycin days of the DAV felt amazing. In fact I have stopped the D&Q in favour of Taurine - which appears superior.
After the DAV protocol I noticed new hair growth in the following months. I am repeating the DAV protocol this October. The only concern I have is with my gut biome. But have put in place a stringent minimize the risk and implement recovery approach (probiotic 1-2 hours after each antibiotic dosage and a rigorous pre-pro-post biotic recover stage)
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It’s good to hear your experience on that. I was leaning towards the DAV protocol and l take taurine too. Much appreciated
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Some of the latest treatments for MS.
Also the statin Simvastatin.
Simvastatin (Flolipid, Zocor) is a statin doctors prescribe to treat high cholesterol. It may also help slow down secondary progressive MS. Some studies show that higher cholesterol levels are linked to worsened MS. Because of this, experts thought simvastatin might slow down MS progression if it lowers your cholesterol. But a more recent study found that the drug directly slows down the progression of MS, even if it doesn’t help your cholesterol levels.
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Neo
#31
Interesting
Two drugs, metformin (Fortamet, Glucophage, Glumetza, Riomet) and clemastine (Dayhist, Tavist), may help rebuild your myelin. Usually, metformin treats diabetes and clemastine helps with hay fever. Researchers found metformin can help myelin-making cells repair it better. Experts found clemastine helped with the speed of messages from your eye to your brain. Animal studies showed metformin can improve the effect of clemastine.
@Walter_Brown have you looked into clemastine? Any thoughts? Myelin is important for everyone as we age.
@italoromeno have been following the metformin and clemastine - and Simvastatin in this context?
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Hi @Neo - yes, I followed the protocol. But I haven’t been able to source more clemastine fumerate here in the UK. If anyone knows of a source (my Indian suppliers were stumped), then please let me know.
As for results of my initial experimentations - didn’t notice any improvement, but would like to try a higher dose and for longer.
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How long did you use the clemastine for?
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I did 5 days only. I would like to increase both the duration and dose, but can’t source in bulk. Anyone know a source?
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