Neo
#466
Can you provide more color on the signal in opposite direction part
Neo
#467
Nowadays very easy and reasonable cheap to check (and don’t have to keep checking a lot of time):
https://empowerdxlab.com/products/product/cholesterol-dx-test?
Fatty acids are best optimized based on testing anyone, omega index, etc, can can also easily be done from home:
https://omegaquant.com/shop/
(I normally do the complete test for 99, but there is a cheaper one for 49h
adssx
#468
Most likely the other way around (for MACE, ACM didn’t reach significance but RR still favours the combination):
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adssx
#469
See also: Comparison of Statin With Ezetimibe Combination Therapy Versus Statin Monotherapy for Primary Prevention in Middle-Aged Adults 2024
the 3-year all-cause death rate was lower in the combination therapy group than in the statin monotherapy group (0.2% vs. 0.4%; p<0.001), with a significant HR of 0.595 (95% CI, 0.460–0.769; p<0.001). Single pill combination therapy exhibited consistently lower mortality rates across various subgroups.
Compared to the statin monotherapy, the combination therapy for primary prevention showed no difference in composite outcomes but may reduce mortality risk in relatively healthy middle-aged patients. However, since the study was observational, further randomized clinical trials are needed to confirm these findings.
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adssx
#470
Not a lot of evidence for atorvastatin and ezetimibe in terms of life extension (or the opposite): Unraveling Potential Sex‐Specific Effects of Cardiovascular Medications on Longevity Using Mendelian Randomization 2023
For lipid‐lowering drugs, genetically mimicked PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors were associated with longer lifespan, particularly in men (2.39 years per SD low‐density lipoprotein cholesterol reduction [95% CI, 0.42–4.36], P for interaction=0.14).
No associations were found for genetically mimicked statins, ezetimibe, or angiotensin‐converting enzyme inhibitors.
Ezetimibe close to statistical significance in men, while statins are on the wrong side for both genders:
3 Likes
I just came in here to try and find my old post to update but saw this so will post here - I’m 71 and LDL has always been high, 130’s to 160’s and after being on rapa a few months it was 171. Total has always been 220’s or so but with rapa 257. Had a calcium test and 0 score. I heard Peter Attia give example of someone similar to me and saying if 0 score with my numbers must have some other protective mechanisms going on. However, that high score and the fact that it had been high for many years bothered me so I went on 5 mg of Crestor. I’ve only been on it three months and just had my lipids drawn yesterday wow it really worked. My LDL is down to 86 and total 174. However, I feel like crap and since I have “chronic fatigue” and fibromyalgia was for awhile thinking just in a bad spell with that, but now thinking it’s the Crestor. No added muscle pain though, and I don’t recall feeling like this the first couple months just past 3 weeks or so. I googled and found that some folks are given as low a dose as 2.5mg once a week and still shows good results so am going to experiment and redraw in 6 months but for now go off altogether and see if feel better. Am no longer on rapa either as was only taking to see if it made me feel better and after 6 months no change, all it did was increase lipids and glucose.
The problem with Rapa is that it works through making mitochondria more efficient. That is really hard to measure. It clearly has effects on glucose and lipids which can be seen very obviously in my tracking of high dose rapamycin.
When you take a single dose and wait a while before you take another then you can see the changes that it induces temporarily. The idea is that the improvement of mitochondria lasts longer (which I think it does).
4 Likes
mondagai
#473
What’s the best Statin to take? The one your doctor prescribes you.
Beth
#474
Just to let you know you are not alone.
I tried statins 20 ish years ago. I even tried 1/4 of a pill every other day or something like that. I never had muscle pain, but I felt glued to the sofa. I hadn’t heard of anyone having that particular side effect which is why I’m chiming in.
It’s definitely worth trying fewer days a week, and low dose, and also various brands.
I couldn’t do it but I’m also a freak, so there we go 
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Thanks for letting me the know Beth because with my fibromyalgia and chronic fatigue it is hard for me to know if something else is making me feel bad and I’m not having the muscle pain so good to know that happened to you too and this could indeed be the statin. I just got to a point where I thought I can’t live with this stuff thinking it was the chronic fatigue and then a lightbulb went off and thought I wonder if it could be the Crestor. It’s a small dose and I usually tolerate drugs well so your chiming in helps. Thanks.
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Beth
#476
I remember saying at the time, and this was before there were any other drugs to treat cholesterol (or that I knew about) that I’d prefer to just die earlier and happier. So, yeah, I get you!
Now, having said that, I was young at the time and not forcing myself to take them until there were other options is actually my biggest regret in life (I have a scary high CAC score and bad family history). I also was told, you have great HDL and a great ratio, so you have nothing to worry about, so yes, don’t worry about taking anything.
Oh well, when we know better we do better….
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Rick
#477
I’m on 80mg atorvastatin. I’ve tried to lower it to 20mg but don’t good on that dose. Atorvastatin is a potent anti-inflammatory which is beneficial.
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