#354

That high dose statins are bad and that ezetimibe and low dose statins are better is almost speculation.

#355

These are hard for many if not most people, at some points in our life. I recommend you check into this mini conference: Stanford U. Mini-Conference (online) "The Household as a Unit of Health Behavior Change", Saturday, March 9th, 11:00 am - 2:00 pm (PST)

Also this book too: Amazon.com

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#356

Thank you.

I will check into those items.

#357

I tried rosuvastatin 10 mg, but after a week I had discomfort in the right hypochondrium, after which I stopped, I suspect that rosuvastatin can cause pancreatitis and liver damage…

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#358

That’s not helpful as it’s not saying what you are doing instead.

#359

Another Korean study looking at this question: Combination of low- or moderate-intensity statin and ezetimibe versus high-intensity statin monotherapy on primary prevention of cardiovascular disease and all-cause death: A propensity-matched nationwide cohort study 2024

Compared to high-intensity statin monotherapy, moderate-intensity statin with ezetimibe combination significantly reduced the risk of composite outcome (hazard ratio [HR] 0.84, 95% confidence interval [CI] 0.77–0.92, P < 0.001) as well as individual MI (HR 0.81, 95% CI 0.71–0.94, P = 0.005) and stroke (HR 0.78, 95% CI 0.65–0.93, P = 0.005), but not all-cause death. Low-intensity statin with ezetimibe also significantly reduced the risk of the composite outcomes (HR 0.80, 95% CI 0.66–0.97, P = 0.024) compared to high-intensity statin monotherapy, but the risk of individual outcome did not differ between two groups.

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(HR for all-cause mortality close to significance in favor of the combination)

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Statin monotherapy vs combination with ezetimibe
#360

Medium-intensity statin with ezetimibe versus high-intensity statin in acute ischemic cerebrovascular disease (MESIA):a randomized clinical trial 2024

Compared to guideline-recommended high-intensity statin therapy, moderate-intensity statin with ezetimibe further improved the achievement rate of LDL-C in patients with acute ischemic cerebrovascular disease, with a higher reduction magnitude in LDL-C. In terms of safety, there was no significant difference between the two regimens, suggesting that moderate-intensity statin with ezetimibe can also be considered as an initial treatment option for patients with acute ischemic cerebrovascular disease.

Unfortunately they defend “safety” as “liver and renal function tests, and the occurrence of statin-related muscle events within 3 months”. I’d like to see new onset of diabetes or just Hb A1c increase.

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#361

Forget the statins and take Bempedoic Acid. There is neither muscle fatigue nor increased risk of diabetes.

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#362

That’s also what I thought but I don’t like the +15% increase in uric acid with bempedoic acid: Effect of bempedoic acid on uric acid and gout in 3621 patients with hypercholesterolemia: pooled analyses from phase 3 trials | European Heart Journal | Oxford Academic

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#363

I’d rather take higher uric acid levels than muscle soreness or diabetes. I’ve experienced muscle soreness from statins and it was intolerable. For uric acid, you can drink more water.

#364

I tend to agree but uric acid seems important: Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort - #5 by cl-user

Anyway now I’m focused on optimizing my BP. Once done I’ll look at lipids. One step at a time… But I guess I’ll start with bempedoic acid/ezetimibe (and/or obicetrapib if approved?).

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#365

Dr Rick Johnson agrees that Uric acid is a driver of poor health. He and others have pointed to Uric acid as one of the top handful of biomarkers to keep in range.

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#366

What are the top strategies to reduce uric acid? Is it a U-shaped curve? Or lower is always better?

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#367

@DeStrider Is lowering uric acid useful for longevity? - #3 by L_Hayes

This thread has a bunch of info. Dr Johnson emphasized reducing purines, as I recall. No beer, sadly.

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#368

I get confused about this. If you search for Dietary Neucliotides here you see people who believe eating yeast is important and will make you live longer. RNA/DNA supplementation. But these are purines and will cause all kinds of trouble. What’s the answer?

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#369

Watch your Uric acid. If it is too high then back off purines. Maybe back off gravy, shellfish, sardines before beer or other yeast source if that is important to you.

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#370

Interestingly molybdenum supplementation can speed up purine processing. I will see if it has a noticeable effect on my urate biomarker.

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#371

That was an interesting piece by Masterjohn. I’ve been checking mine for a few days around Ph=6. I’m about to start the supplement. Exciting times.

#372

I had the results of a hair test so i have not done a specific Mo urine test. My urine when not drinking tends to be quite alkaline.

#373

There is 10 mg Monacolin K in BJ’s red yeast product:

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