#364

I tend to agree but uric acid seems important: Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort - #5 by cl-user

Anyway now I’m focused on optimizing my BP. Once done I’ll look at lipids. One step at a time… But I guess I’ll start with bempedoic acid/ezetimibe (and/or obicetrapib if approved?).

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#365

Dr Rick Johnson agrees that Uric acid is a driver of poor health. He and others have pointed to Uric acid as one of the top handful of biomarkers to keep in range.

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#366

What are the top strategies to reduce uric acid? Is it a U-shaped curve? Or lower is always better?

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#367

@DeStrider Is lowering uric acid useful for longevity? - #3 by L_Hayes

This thread has a bunch of info. Dr Johnson emphasized reducing purines, as I recall. No beer, sadly.

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#368

I get confused about this. If you search for Dietary Neucliotides here you see people who believe eating yeast is important and will make you live longer. RNA/DNA supplementation. But these are purines and will cause all kinds of trouble. What’s the answer?

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#369

Watch your Uric acid. If it is too high then back off purines. Maybe back off gravy, shellfish, sardines before beer or other yeast source if that is important to you.

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#370

Interestingly molybdenum supplementation can speed up purine processing. I will see if it has a noticeable effect on my urate biomarker.

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#371

That was an interesting piece by Masterjohn. I’ve been checking mine for a few days around Ph=6. I’m about to start the supplement. Exciting times.

#372

I had the results of a hair test so i have not done a specific Mo urine test. My urine when not drinking tends to be quite alkaline.

#373

There is 10 mg Monacolin K in BJ’s red yeast product:

image

#374

Finally BJ is taking lipid lowering medication?! You must be in heaven! :wink:

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#375

It’s not only a lipid lowering medication, it is a statin. Monacolin K is another word for lovastatin. Contrary to popular opinion, red yeast rice containing Monacolin K is allowed to be sold as a supplement as long as it is not ‘enhanced’ or have added lovastatin to the product according to the NCCIH.

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#376

Do you have any idea about the expected apoB reduction from a 10mg dose? Perhaps around 30%?

#377

No, not 30%, that is the effect of 5 mg rosuvastatin and it is much more potent. I don’t know and how much the garlic would help as well.

#378

5 mg rosuvastatin reduces LDL by 40%, not 30%: https://www.researchgate.net/figure/Reduction-of-LDL-C-levels-with-rosuvastatin-or-comparator-statins-in-two-12-week-studies_fig5_51437609

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#379

30% ApoB reduction, not LDL.
40 mg lovastatin seems to reduce apoB by like 16%.

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#380

I’m actually thinking of trying Red Yeast Rice - this one:
https://renuebyscience.com/product/cardiomax/
But I’m going to ignore this comment - @AnUser “It’s not only a lipid lowering medication, it is a statin.” Because when I see the word “STATIN” it’s like waving a red cape in front of a bull (me). But in this case the red yeast rice is liposomal encapsulated so I’ can’t see that it’s red.

#381

It is arguably an inferior statin so if you are going to use one might as well join the synthetic crowd.

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#382

Who you calling “inferior”? It might work for me…I can always move on to the hard stuff later.

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#383
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