The Ora Medical Million Molecule Challenge (see this thread for more info) has Vanillin as a significant lifespan extending intervention in C. elegans with ~12% longer median lifespan.
I couldn’t find much information on vanillin in these forums so this post can serve as a starting point for research on this substance.
@John_Hemming linked to this study that shows senolytic effects of vanillin.
@Viracocha found a study showing vanillin has a whole host of positive impacts.
https://www.sciencedirect.com/science/article/pii/S2772417422000279
It could be cardioprotective, “ameliorating myocardial infarction through enhancing cardiac angiogenesis and modulating oxidative stress, inflammation and apoptosis.” And it does this by “upregulating Akt/HIF-1α/VEGF signaling.” See potential of VEGF here.
Vanillin appears to be neuroprotective. It is an AChE inhibitor, in mouse Alzheimer’s Disease, “30 mg/kg per day, preserved intact acetylcholine and significantly improved spatial reference memory.” And in Parkinson’s, “vanillin has a role in protecting dopaminergic neurons via inhibiting inflammatory response activation.”
Mixed results for cancer “found for vanillin suggest that other carcinogen models must be evaluated to better understand the role of vanillin on carcinogenesis” according to this review.
Overall, some positive indications for vanillin, but it’s very understudied and questions remain on safety and lifespan expansion in mammals. It’s one I will keep on my radar but way too early to adopt.
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Bicep
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They say actual extract is $4000/kg vs the synthetic version is $15. I like the idea of using the actual bean extract but you could afford to use 250 times that amount of the fake stuff.
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