#275
2 Likes
#276

Wow, so curcumin actually turns into vanillin?

#277

I thought you might be a fan of melatonin getting tested :wink: but you also wont alter your stack anyway no doubt.

#278

I am continually making changes to my stack and testing. The test results and hypotheses drive the changes.

1 Like
#279

I’m trying to see which pathway does Vanilla affect because I don’t need another NRF2 activator, but surprise surprise, it touches everything!!

What an amazing molecule:
https://www.sciencedirect.com/science/article/pii/S2772417422000279

4 Likes
#280

Hear me out:

Lifespan Extending Vanilla Ice Cream
Ingredients

  • 1 gallon BB12 yogurt (smuggled from Japan)
  • 100g glycine (for sweetness)
  • Vanillin (enough to achieve 50µM concentration)
  • Vanilla bean, powdered (for show)

Directions

  • Mix all ingredients slowly so as not to stress out the BB12 culture
  • Follow Yogurtland process to freeze into frozen yogurt

Servings: 6, or 1 if you’re breaking a long fast

Goes well with: other palid foods, like skinless sardines in EVOO, or microwaved shitake mushroom; or if you’re @Agetron, goes well with steak and potatoes, like any other food.

8 Likes
Vanillin - Best Tasting Lifespan Extender?
#281

Good recipe for blueprint ice cream

1 Like
#282

Synthetic or natural vanilla, which one did they use in the study?

#283

From what I see, they use Vanillin, the synthetic product.

1 Like
#284

Natural vanilla is a lot more expensive

#285

It looks like leaderboard updated and sulforaphane has been dethroned by Doxycycline Hcl!?
D-Mannitol and Xylose sweeteners seem to also be pretty good.

2 Likes
#286

Rapamycin + Berberine-Hcl also extremely effective! Moreso than GSK2126458 + Berberine or metformin!
(Neither rapa nor berberine by themselves did anything, and the GSK chemical is strong by itself or with just about anything it seems)

3 Likes
#287

Waiting for someone to double worm lifespan or something, at this relatively marginal difference it doesn’t look so enticing to even consider without mouse data. If you made a worm immortal that would be different.

An off-shoot project might be a LEV worm project. Feed worms one substance for awhile then switch to another one. If that even have any biological plausibility.

3 Likes
#288

They told me they haven’t finished updating the full leaderboard yet.

#289

Why don’t you sponsor compounds yourself or suggest some here instead of waiting for someone to do the job?

2 Likes
#290

Waiting for use in humans.
To be clear, I was remarking on when to consider even investigating a substance for use in humans without mouse data. The results can be interesting or even impressive but still not ready for human use. I don’t know when it is.

#291

Ah yes, of course. The next step for Ora Biomedical is to test in human cells. Then mice. Worms are just here to identify some candidates on the cheap.

5 Likes
#292

What does testing on human cells look like? They measure lots of stats for cell health like divisions or mostly just look at some sort of avg lifespan of individual cell? Is there any evidence that it scales to mouse or human lifespan? I know I have seen in vitro models to show a drug is absorbed and effects a certain organ, maybe even helps a dementia model like reducing Aβ plaques, but not for lifespan effects.

#293

You’re right the cell models are more for specific diseases (Ora Biomedical is also working on that). I don’t know for lifespan.

#294

Look at the CAS number and if that is the “same” then it’s the same compound with a different description. If it’s different, try to find what is used in trials, with a CAS number.