#1

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Hello Everyone…

…So, I may have done something harmful, and -

NOT looking for Medical Advice,

and also, Understood, anyone who responds, is NOT giving me Medical Advice(!) ;

…just maybe some folks can comment on what is going on, from a Science standpoint,

…and …Please be KIND,

because, if I’ve done something I shouldn’t, it’s because I don’t have the scientific understanding that some of you do…

…Okay…

So…

…This week, I got

…not just one, but THREE vaccines

(Covid …Pneumonia, and TDAP [Tetanus, Diptheria, and Pertussis])

all at once,

…Plus, yesterday I also got an Allergy Test, in which 70 different allergens were injected into my arms (both arms),

(…And, I also got Nine (9) Tubes of Blood drawn for testing…)

…My last dose of Rapamycin, prior to the Vaccines, was last Friday night (5 days before the vaccines),

and I was doing okay, for the 2-3 days following the Vaccines, other than just having some heaviness of my arms ;

***SO I DIDN’T THINK ANYTHING, ABOUT PREVIOUS RAPAMYCIN -

NOR… (Allergy Test, or) TAKING THE NEXT RAPAMYCIN***

…Yesterday,

***One week after last Rapa,

and 3 days after Vaccines***

(I got the Allergy Test, and) at night (3 days after the Vaccines, from which I seemed fine), I took my next Rapamycin…

…This morning, as I was waking up (still sleepy),

I noticed my left arm (Pneumonia & Covid site), the Vaccine site was swollen, but I didn’t think anything of it because I was still half asleep,

…and I may have lightly scratched, because I wasn’t really thinking straight yet…

…By the time I fully woke up, and went in the restroom,

…I had a Red “Goose Egg” (Bump), the size of my hand…

(And still have the “Goose Egg,”

and, a dull ache down to my wrist)

…Now I am worried, and thinking of all the things I should have thought of -

like, whether - from a scientific standpoint -

…A person’s not supposed to get any Vaccines, while on Rapamycin(?),

…/how long is a person supposed to wait After their last Rapamycin dose, before it would be safe to get a Vaccination(?),

…/how long is a person supposed to wait, After a Vaccination, before they can start Rapamycin, again(?)

…Also wondering if the Allergy test can have caused, or contributed, to this -

besides the Allergens themselves,

…the needles likely pierced the Same Site where I’d gotten the Pneumonia & Covid Vaccines…

(And I don’t feel like it Helped matters any, getting Nine tubes of blood taken out,

and that needle inserted into the blood vessel in the Same Arm as the Covid & Pnuemonia Vaccines -

…if nothing else, it has just been a lot to put my body through, in a short time…)

…And lastly, I’m wondering

whether I have reduced the effectiveness of the Vaccines I have gotten?

(I tried to read, online …but don’t have the scientific knowlege to understand…

(Also not sure if I should go to the hospital…

I’m trying to wait until like 3:00pm to see that the swelling doesn’t get any worse,

and then this evening to see if it starts to go down…

…Thank you to anyone who read my entire, extremely long post,

and,

…if nothing else, my post can serve as a Cautionary Tale …to anyone who at least has the foresight to reasearch before they get vaccines WHILE ON Rapamycin,

which …I didn’t think of, because

it had been 5 days since my last Rapa, and then 3 days since Vaccines before Next Rapa,

And I had felt mostly fine for 2-3 days after the Vaccines, and …thought they had already done their “acute” work, and would not then be affected…

…Thanks, everyone…

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#2

Can’t you call the vaccine provider & later the allergy testing place saying you forgot to disclose you were taking sirolimus (an immuno-suppressant) and recently got vaccinated and ask?

It’s better to get actual medical advice, because the best answers you will get are from experts.

2 Likes
#3

Don’t beat yourself up!

N=1
I’ve had multiple vaccines at one time and had my vaccines soon after my rapa with no issues. I normally space them out only to tamp down the misery.

If I recall, I THINK Joan Mannick even showed flu vaccines might work better with rapa.

I don’t remember when I took my next rapa dose after my vax, it was either the next week or I skipped a week at most.

I’m GUESSING this is mostly about your allergy injections. Maybe there is also a chance rapa and allergens don’t mix? Did they tell you what to do if you have a bad reaction? If not, I’d call their office and see if someone is on call.

4 Likes
#4

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thanks @AnUser , that’s really good advice, And, without chastising me :slight_smile: -

if the swelling doesn’t start to go down, by tonight,

i will call the vaccine provider’s office, and tell them i didn’t think anything of being on Rapamycin and getting a vaccine -

and that’s the truth -

had i thought anything of it, i would have asked beforehand about risks,

or at least i would have stopped rapa for (maybe 1 week before AND 1 week after)…

…i am still curious though, and

(noted, mention above, of flu, but…)

hoping that rapamycin won’t …lessen the effectiveness of the vaccines -

…can anyone shed any light on this?

…thanks, all,

everyone here always so helpful!

wishing all safety, good health, and happiness! :slight_smile:

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1 Like
#5

I hate vaccines so I did them all at once while on rapamycin last year with no problems. RSV, Shingrix, pnemonia and flu. A little redness and swelling that went away in a few days. No real issues short or long-term.

Some shots required a repeat later after a month. Maybe take an over the counter benadryl.

1 Like
#6

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hi, @Agetron, thanks for sharing your experience :slight_smile: -

but in my case, Maybe the rapamycin did something (i think this because, i didn’t have any swelling until after i took the rapa, 2-3 days After the vaccines ) -

OR …the allergy test did something, perhaps a few allergen factors got infused with the vaccine compounds

…there is still a very large swollen area, larger than my hand …but otherwise, i feel okay, and i’m just trying to ride it out…

i just hope i didn’t compromise the vaccines’ effectiveness…

thanks everyone!

1 Like
#7

This could be a bacterial infection. You should see a doctor.

2 Likes
#8

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hi @Pender and everyone -

yes,

sadly,

even though i don’t feel bad,

the very large lump, and redness, have persisted,

and are maybe even slightly bigger,

so -

coincidentally, after the allergy test,

to which the Dr. felt i had no response (“no allergies”),

we talked about me getting immunotherapy for Other allergies (just environmental), discovered on PREVIOUS (months ago) test,

and

she prescribed me an “epi pen,”

for when i would start the immunotherapy -

…little did we realize,

i might need the epi pen this weekend! :frowning: -

but so, thank God,

i am going to

(a) get the epi pen, now,

and (b) ALSO go to an urgent care center,

and i will ask them if this can be a bacterial infection or anything else instead, too ;

will post back, tonight,

depending what happens…

thanks everyone, for helping out with my concerns -

this is a wonderful community, i’m so grateful to be a part of :slight_smile:

wishing safety, good health, and happiness to all! :slight_smile:

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1 Like
#9

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Dear Beth,

i’m so sorry for the late reply,

i hope i didn’t make you feel ignored!

i just wanted to take the time to not just write a quick, generic reply -

…i always so appreciate your replies to my posts!

…you are so helpful, to myself AND others(!),

and, thank you for being SO KIND!

and i think there is something to your thought that this reaction could be connected to the allergens

(/maybe the allergens got infused INTO the vaccine site, and somehow caused a problem, or, i don’t know -

this stuff is over my head! -

and now i AM [going to get an epi pen that my Dr. had coincidentally prescribed to me for OTHER reasons,

and]

going to go to an urgent care center and get a Medical Professional to figure this out :))

will post back, tonight, God willing -

thank you Beth Dear, and everyone(!), again, for your support!

wishing safety, good health, and happiness, to all! :slight_smile:

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1 Like
#10

I definitely did not feel ignored!!!

I hope you have good luck at urgent care and let us know how you are!

1 Like
#11

In principle, there’s nothing wrong with getting vaccines when taking Rapamycin. If you think about it, on any given day your body is experiencing a massive variety of different antigens and pathogens. Like, the food you eat has a bunch of dead cells with cow proteins, plant proteins etc. Every person you see is spewing bacteria and viruses onto you. Every time you scratch your nose you’re introducing bacteria. What you’re getting in a vaccine is a very small amount of pathogen exposure compared to daily life.

Point is, your body is 100% capable of handling 3, or 5, or 10 simultaneous vaccinations.

The real “difference” is that the thing you’re being vaccinated is generally unfamiliar - i.e. you aren’t likely to have had much experience with tetanus or diphtheria as you have the various rhinoviruses and coronaviruses that give people sniffles. That’s why you get the redness, swelling, pain at injection site. It’s a sign that the vaccination is working, because you’ve stimulated a nice strong immune response. Though, there is a line and if you’re having a very severe response, possibly you’re actually allergic to one of the components. I would think redness and swelling is pretty normal, especially when you got multiple injections in the same arm. But the place that administered the vaccines should be prepared for you to call and describe your symptoms and they’ll ask questions (like, is your breathing ok, any chest tightness etc) and tell you if it’s normal or not.

2 Likes
#12

It wasn’t only vaccines but also allergy test with 70 allergens.

#13

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TLDR y’all MD and Vax provider were closed, And couldn’t get Epi Pen,

and Urgent Care was useless, gave me a cream for “dermatitis” ;

don’t wanna go to ER,

trying to wait til tomorrow for MD to open or Epi Pen to be available :frowning:

hi, @relaxedmeatball , and @AnUser ,

yes, i was saying i had thrown a lot at my body for sure,

…thinking that i could have caused this with the rapamycin, was because,

i had absolutely zero reaction to the vaccines, after i got them,

(which, i was literally Expecting to get swelling from the Tetanus Diptheria Pertusis Combo one, because in the past i was told that one often causes that,

but then i got Zero reaction, even to that…)

two days passed, and i thought my body had already moved on -

and Same for the “allergens,” which were ‘just’ food ingredients …and my MD literally declared that i’m not allergic to anything,

…and i continued to Not have any reaction to either the vaccines, Nor the “allergens,” the whole day after i got the allergy test -

it was only after i took the rapamycin before bed on friday night

(then 3 days after the vaccines, that i had all but forgotten about, because zero reaction,

and 12 hours after the “allergens” …to which my MD declared i’m not allergic to anything)

…that i woke up in the morning with very large swelling

(and ironically, it wasn’t the tetanus diptheria pertusis combo side, it was the covid and pneumonia side, which i would think i get some exposure to, even…)

so it SEEMED,

to my, uneducated opinion,

that maybe the rapamycin could have supressed my immune system and caused this,

…and/or, Yes, we have been talking about that i did throw a lot at my body,

and,

yes, maybe i Am indeed allergic to some of the allergens ( @AnUser ), or allergic to a component of the vaccine(s) ( @relaxedmeatball ) ;

anyway, y’all,

vaccine provider was closed today,

AND two pharmacies didn’t have epi pens either (!)

(like, what the heck?, there are people out there with such severe anaphylactic reactions that They could DIE …and every pharmacy should have at least THREE epi pens at all times!)

allergy test MD was also closed,

…and

…urgent care was useless :frowning:

…gave me a lousy cream for DERMATITIS :roll_eyes:,

…arm swollen like a big red hamhock :meat_on_bone::cut_of_meat: ;

i don’t wanna go to the E.R.,

am trying to hang in there until MD is open tomorrow and/or epi pen available :frowning:

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#14

Sure. But even then, on an average day you’re being exposed to way more than 70 potential allergens. Animal hair and skin, pollen, all the stuff in all the food you eat, all the products you apply to your skin, insect bites etc.

I think that’s very unlikely. More likely is that you’re actually having a big response to the vaccines.

#15

@relaxedmeatball (i was thinking suppressed immune system and therefore vaccines wreaking a bit of havoc lol :slight_smile: …anyway, i will ask MD to sort it out tomorrow …and i will let everyone know what turns up)

#16

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hi, all (hit reply, to you, @relaxedmeatball , but this is just a general update),

finally got a hold of MD, and …she couldn’t be bothered to try to find out what caused this -

SIDE DISCUSSION:

whether rapa’s immune suppression “let the vaccines and/or allergens wreak a little more havoc” -

today, my therapist - with no medical background whatsoever, of course,

said, to him it seems just “common sense,” that

…if one is immunocompromised (…or suppressed),

it seems “ludicrous” to get a vaccine,

for just that reason,

that your body might be overwhelmed by the vaccine(s) -

then, on the completely other end of the spectrum,

pneumonia vax own commercial i just heard today, said:

if immune compromised (or suppressed…),

you may have a LESSER response to the vaccine -

as in the vaccine may offer you less protection… -

so i do worry about that…

…and/or, now working on the theory that the rapa didn’t have anything to do with the reaction,

…MD also couldn’t be bothered to try to find What i AM allergic to,

whether any of the vaccines, or any of the food allergens,

…and just told me to “take a benedryl” (!)

…well,

further off topic:

i would only want to risk taking a small dose of FEXOFENIDINE, INSTEAD,

…cuz benedryl is an anti-cholinergic, y’all -

saturates receptors in your brain, and increases your risk of dementia, y’all -

no thank you :slight_smile:

(sorry, i feel so strongly about this,

i am a walking unwanted public service announcement,

cautioning everyone i meet,

to try to avoid anti-cholinergic drugs!

…i forget the name, but you can search online for an “anti-cholinergic drug CHECKER” ;

you just type in the name and it will tell you the risk,

0 being the only safe option,

the higher the number, the more dangerous!)

and …i didn’t wind up taking nothing,

i’m just gonna ride this out without dr.'s,

been no help at all with this…

so this mystery will have to stay unsolved, sadly,

but …i’m so thankful i had everyone here,

to give your great input,

and to lean on :slight_smile:

wishing safety, good health, and happiness to all! :slight_smile:

.

1 Like
#17

Well, I would take this remark from a totally unqualified person and just put it right into the trash. No offence, but it’s fair to say that even your regular family doctor who actually has an MD degree is going to be less knowledgable about Rapamycin than the forum members here.

Rapamycin is not a blanket immunosuppressant, especially with weekly dosing.

And the logic is straight up wrong. Somebody with a low immune system would WANT vaccination to give their body more chance to response and build up protection against the viruses, bacteria that might infect you.

There is no such thing as “overwhelmed by the vaccines”. As I said, on a random day you encounter a massive variety of different antigens. It’s no big deal.

And, I’m not trying to be mean here, but maybe the pharmacists and doctors brushing you off is because you’re just having a normal reaction to getting vaccinate. A sore swollen arm is pretty much the most common adverse event.

4 Likes
#18

Yes - this is true generally, but you can be a little more refined in the analysis. They group this class of drugs into three groups, with the 3rd group being the worst. See below.

Source: Harvard Health

https://www.health.harvard.edu/blog/common-anticholinergic-drugs-like-benadryl-linked-increased-dementia-risk-201501287667

Anticholinergic-cognitive-burden-scale.pdf (309.4 KB)

1 Like
#19

@relaxedmeatball

please don’t try to tell me i’m over reacting -

my arm got so swollen, it’s like i’m about to tip over to one side,

and my MD never even saw my arm - so it’s Not that “she brushed me off because it’a not actually that bad”

and also

reaction didn’t start until after i took the rapamycin, plain and simple. -

3 days, zero reaction, prior.

and i’m Not maligning rapa, but

if it Does temporarily reduce immunity after a dose,

(and post-dose bloodwork indicates that it Does.)

it makes sense that vaccine(s) would cause more of a stir, so to speak.

…arm Still humongous & weighs “500 pounds”.

so please, don’t try to tell me i’m over reacting -

it really was unnecessary of you to add that…

thanks for your opinions, and wish you well…

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#20

I think you are feeling sensitive and vulnerable right now. We all understand that… it’s scary when you have a reaction and your doctors are of no help.

I just want to say that relaxedmeatball was in no way being unkind and he has gone out of his way to try to be very helpful. I think you might see that after you recover.

I hope you get better really soon!!!

1 Like