#1

What’s the reasoning behind larger yet less frequent dosing of rapa (5mg+ every 7 days +) versus taking .5 or perhaps 1mg daily?

Is the strategy guesswork or backed by some scientific research? Thanks in advance for feedback.

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#2

See this post: What is the Rapamycin Dose / Dosage for Anti-Aging or Longevity?

The issue with dosing daily is that this is the dosing strategy used in organ transplant patients and, because of the long half-life of rapamycin (around 70 hours) it builds up in your body, and it can greatly increases risk of mTOR2 inhibition, and immune system suppression.

I recommend you read as much as you can here: Rapamycin Frequently Asked Questions (FAQ)

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