一项新的研究发现，自噬在激活毛囊干细胞和保持头发生长周期中发挥着重要作用。通过促进自噬，雷帕霉素改善了小鼠和人类毛发器官培养物中的毛发生长。
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来源论文：
结果：毛囊干细胞 (HFSC) 的自噬在休止期到毛发生长初期的过渡期间最高。用 3-MA 抑制自噬导致提前进入退行期并延长休止期，而 Rapa 则促进自噬和毛发生长。自噬通过增加HFSC乳酸脱氢酶（Ldha）的表达和活性来激活HFSC，从而将HFSC代谢转变为糖酵解。 Ldha 表达的抑制抵消了自噬的影响。
结论：自噬通过促进HFSC代谢向糖酵解的转变而激活HFSC，最终启动毛囊周期并促进毛发生长。
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其他关于头发生长和雷帕霉素的论文：
此处： mTORC1 活性对人类毛囊生长和色素沉着产生负调节
和：
通过激活自噬的小分子刺激毛发生长
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30699-0
'雷帕霉素 (1.6 mM) 诱导毛发再生。雄性小鼠在出生后第 43 天被剃毛，并每隔一天进行局部治疗。照片是在治疗后第 37 天拍摄的。
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这里： 外用雷帕霉素生发方案
11 Likes
murraci
#2
I’ve probably seen around 100 papers on rapamycin now. I’d say 95 of those resulted in positive results for whatever they were testing. You could throw darts at a dartboard to test any metric of human healthspan and almost certain to find rapamycin improves it.
5 Likes
The sad thing is that negative results are less likely to be published for anything. However, more efficient mitochondria are likely to make any issue better.
3 Likes
murraci
#4
In many cases yes but I don’t think in the case of rapamycin because nobody has a patent on it. The people doing the studies have no dog in any hunt.
6 Likes
I do wonder whether high doses of oral rapamycin can accumulate in the hair follicle aswell.
I think it is a general problem with research. In a sense there is an inherent systemic pressure for positive results. When it comes to rapamycin and hair i think rapamycin helps.
1 Like
约瑟夫
#7
FWIW
Dissolve rapamycin in DMSO, then make a solution and rub into the scalp.
You will deliver rapamycin into the hair follicle/hair stem cells (HFSCs)
1 Like
This is strictly anecdotal, but my cat was shaved almost to the skin for his ultrasound. The hair started growing back, but slowly. After he had been on Rapa for a couple of weeks, his fur suddenly started growing back very quickly, and is now very thick. This could just be his winter coat coming in, or maybe I’m seeing what I want to see, but the results seem to confirm the mouse study
4 Likes
DrT
#9
Hmmm. This suggests an experiment. First, you need a sufficient number of cats. Let’s say 20 controls and 20 to receive the rapamycin. They should be shorthair cats…easier to shave.
Second; begin by herding each group of cats toward the lab….oh, never mind!!
7 Likes
DrT
#10
So it seems that topical rapamycin, metformin and alpha-KG are all fairly effective on the mice and also have some effect on human follicles.
I’m tempted to try all 3 concurrently but then, if it helps, I won’t know what is best. Has anyone tried any of these yet?
1 Like
Arhu
#11
With topical applications you can do left/right side comparisons
2 Likes
DrT
#12
True. I used to do that several years ago. Treatment on left side. Right side was control.
1 Like
You forgot the sedative (for you, not the cats) and the chain mail gauntlets
6 Likes
Was the difference very significant?
Possibly a daft question here, the study shows results in 11 days. Assuming this was also effective in human HFSCs would we be looking at 11 days, longer or shorter?
1 Like
Melih
#17
Mice hair growth cycle is like ~28 days total from the telegon to the anagen phase.
Whereas a human hair growth cycle can go anywhere from a couple months to a couple years.
The healthier the hair the longer the hair cycle is in the anagen phase.
3 Likes
DrT
#18
It’s so long ago I even forget what I was trying. And no; no significant difference anyway. 
1 Like
DrT
#19
