#1

I don’t work for Healthspan but use one of their products. Their claims regarding the various effects on hair are interesting, especially pigment preservation.
Most of us are aware of those purported effects, nevertheless it’s nicely summarized.

Introducing Topical Rapamycin for Hair

Over the past two years, substantial research findings have emerged linking cellular senescence and impaired autophagy to the onset of hair loss. Today, Healthspan is introducing Topical Rapamycin for hair regeneration, an innovative therapeutic formulation designed to target the underlying cellular mechanisms contributing to hair thinning and loss.

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What does the science say?

At the foundation of Topical Rapamycin for hair regeneration lies the principle of cellular autophagy—a natural process of cell rejuvenation. Unlike conventional treatments, Topical Rapamycin directly targets cellular senescence and autophagy impairment in hair follicles.

Senescent hair follicle cells exhibit a diminished capacity to respond to growth signals, thereby impeding the initiation of hair growth. By targeting these senescent cells and enhancing autophagic activity, Topical Rapamycin reduces the detrimental effects of cellular aging on hair follicles, thereby fostering an environment conducive to hair regeneration.

This formulation is the culmination of extensive research, including a notable study at UCLA, where topical application of rapamycin demonstrated a significant acceleration in hair regeneration. Research suggests that Topical Rapamycin, by boosting autophagic activity, enhances the health and vitality of hair follicle cells, leading to healthier hair.

What Makes Topical Rapamycin for Hair Unique?

  • Targeted Action: Topical Rapamycin activates autophagy in hair follicles by targeting the mTOR pathway, sparking hair follicle stem cells’ growth and rejuvenation. This accelerates hair regeneration, leading to a quicker onset of hair growth.
  • Science-Backed: Developed based on cutting-edge research, Topical Rapamycin for hair is formulated to counteract the effects of cellular aging and dysfunction in hair follicles.
  • For Everyone: Suitable for all hair types and genders, addressing universal concerns of hair thinning and loss.

Embark on Your Journey to Healthier Hair

  • Easy Application: Simply apply topically as part of your daily routine.
  • Visible Results: Witness the transformation of your hair, with studies showing noticeable improvements in hair growth and vitality.
  • Expert Support: Our team of physicians and specialists is dedicated to guiding you through your hair regeneration journey.

Available Nationwide

Topical Rapamycin for hair is widely available across the nation, with the exception of Alabama, Arkansas, District of Columbia, Minnesota, and Mississippi.

Important Note:

Topical Rapamycin for hair must be prescribed after completing an intake process. Our dedicated team of physicians will help determine if this treatment is suitable for you, ensuring a personalized approach to your hair care needs.

Join us in this exciting new chapter of hair care. Experience the difference with Topical Rapamycin for hair regeneration.

Sincerely,
Healthspan

The Benefits of Topical Rapamycin for Hair

Topical rapamycin promotes hair regrowth by activating autophagy in hair follicle stem cells, initiating the hair’s natural regrowth phase and offering a novel approach to combat hair loss at the cellular level.

Autophagy-Induced Follicle Renewal

Rapamycin engages the autophagic pathway to enhance hair regeneration, stimulating and expanding the population of vital stem cells for a comprehensive follicular revival.

Countering Follicle Aging

Our targeted approach with Topical Rapamycin directly challenges the aging process in hair follicles, reducing senescence and fostering a thriving scalp environment for robust hair growth.

Regeneration Acceleration

By amplifying autophagy, Topical Rapamycin propels hair follicles into a dynamic growth phase, speeding up the regeneration process and enhancing overall cell vitality.

Pigment Preservation

Rapamycin’s sophisticated action on autophagy and the mTOR pathway also shows promise in supporting melanocyte integrity, offering a potential shield against premature graying and preserving natural hair color.

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#2

On this forum there are many posting with members making there own topical rapamycin “solutions” some IV/IM solutions.

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#3

It’s logical that they would provide pictures of before and after but there are none. That’s a huge red flag.

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#4

Interested to know if anyone signs up for this and is willing to share the label/contents/concentration information. I like what they’re doing, in general, but making rapamycin more readily available, but I’d rather talk to my primary doctor about it / use his compounding pharmacy.

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#5

I think the basis for trying this is the basic research, not results shown (yet), though people are reporting good results from their solutions… but people are doing many things, and I don’t know how the people’s solutions here compare to that of Healthspan’s.

Related reading:

here: Rapamycin, Autophagy and Hair Growth (New Paper)

here: Rapamycin for Hair Growth and Hair Pigmentation

here; 雷帕霉素拯救头发生长

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#6

Their treatment starts at $140 a month. Maybe I’m jaded/biased because with the information on this board, I know one can create a plan for a fraction of that.

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#7

Some people here have zero interest in the DIY approach to making these types of solutions, and for them perhaps its worth it to just buy a remade product.

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#8

Yes, you’re right. Maybe they’re the majority. The members here are certainly not the mainstream.

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#9

Well if rapamycin works topically to restore pigment and promote hair growth both on scalp and other body areas wouldn’t it work orally as well? There are many who are using it orally and can comment further. Personally I have been using sirolimus 0.2 % cream topically and orally, 10 mg once a week, for the last 5 years. My observations are as follows: orally no effect or negligible effect on hair growth or pigmentation. For sure inferior in that respect to dutasteride and or minoxidil. Topically appears to at least not affect negatively either pigmentation or hair growth. Maybe benefits it slightly. Again inferior to topical minoxidil and or dutasteride.

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#10

Are you using the topical rapamycin cream on your scalp? If so, how long have you been using it for and how often do you apply it? Thanks.

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#11

Twice a day for 5 years. Once in a morning and then at nighttime. 0.2% sirolimus cream custom compounded by the US based pharmacy. I apply it only to some scalp areas both due to the cost and the fact that I want to compare and contrast results.

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#12

Thanks for the quick reply. 5 years is a long time. I’m assuming you’re applying it to your scalp to treat hair loss. Sounds like you’re seeing little to no new hair growth. If that’s true, why do you continue to apply it topically?

I’ve been applying 0.2% Rapamycin cream with EGCG to my scalp for 3 weeks now. Was hoping to find someone who has achieved the desired results (restoration of hair). I was thinking of microneedling in addition to applying the topical solution.

My plan was to give it three months to see results.

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#13

Why I keep on applying it? My objectives with respect of rapamycin are two fold 1) verify the long term benefits on skin and hair. continue using it unless outcomes are clearly negative 2. hair maintenance and not so much hair regrowth. For hair regrowth microneedling + minoxidil + dutasteride are proven tier 1 methods.

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#14

I have mentioned before but the molecular weight of rapamycin is too large to be absorbed through your skin. I have strong doubts this would penetrate to the hair follicle and have any effect when applied topically.

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#15

There are human studies that show skin appearance improvement with topical rapamycin.

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#16

Yes - the molecular weight of sirolimus is 914.187 g·mol−1

But how do you explain this? Rapamycin May Slow Skin Aging (Drexel U. Study)

and, I spoke with Allesandra Zonari, Chief Scientific Officer for OneSkin, at the Longevity Summit in December - and they see a significant reduction in key cytokines in skin with rapamycin: Highlights from the 2023 Longevity Summit - #4 by RapAdmin

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#17

If you are taking oral rapamycin is there any additional benefit to using topical rapamycin? Or does anyone really know?

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#18

There have been no studies done comparing oral rapamycin and topical rapamycin, or oral plus topical rapamycin (for skin aging or hair growth) so we don’t have any definitive information on this.

But, there is research that supports topical (for skin aging, and hair growth), and there is research showing that the topically applied rapamycin does not get into the blood stream, so it seems like the effects of oral and topical are likely separate, and potentially additive.

I personally do both, oral and topical, and have seen benefits from both independently and combined.

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#19

The fact that there is no detectable rapamycin absorption may be simply due to the low dose (.001% in Dr. Green’s formulation. Wonder if this has been looked at with the higher dose forms available (HYFTOR). Suspect more frequent side effects with higher doses. Concentrations of the home brew formulations are all over the place. Adds to the difficulty of comparing results.

#20

Yes, they were testing 0.001% in this study where they did not find any systemic absorption, but they’ve tested much higher dosing levels in some studies (I’ve not looked closely at the issue of systemic absorption in these studies): Rapamycin May Slow Skin Aging (Drexel U. Study)