#492

Welcome aboard, @sleepdoc. Would enjoy hearing more details about the bioregulators you’ve been taking, along with their rationales, mechanisms, and effects.

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#493

You might be overusing it. Several researchers recommend intermittent use, such as large doses twice a year.

#494

Not sure what overuse would look like. That would suggest side effects or loss of efficacy. There are almost no reported side effects at any dose, so the real question would be what is the most efficacious dosing strategy. In theory the bioregulators signal cells to express more youthful proteins. Turning back the clock to some degree. In our youth these proteins were expressed continuously or pulsed daily, and we aged more slowly. That would argue against the need for a washout period.

For the core peptides, pineal, thymus and blood vessel I like to load i capsule of each, twice daily on an empty stomach for a month followed by 2 caps daily for 10 days each month thereafter. I do the same for the other ones I add to get more specialized effects. For instance using Visoluten for vision. You can dose up to five different compounds at a time.
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Khavinson, the inventor of the bioregulators usually suggested the protocol described above.

To sum it up, I have personally been doing the monthly loading dose followed by ten days a month with good results. No serious problems other than a thinner wallet. The intervals for most people are not consistent due to shipping and financial constraints. Effects are still excellent. I think it is likely having a more consistent higher level as we age is optimal.

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#495

Well, I’m a Seedling, which is to say I follow Dr. Seed’s advice whenever possible. He recommends intermittent use to avoid desensitization and says that one possible side-effect is peripheral edema, something I’m susceptible to. I confess that I sometimes use a peptide more often than is recommended.

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#496

I have been to Dr Seed’s conferences. The thing I notice is how awesome everybody looks. Most medical conferences are composed of really unhealthy looking people. Not his! That said all peptides are different. I think the ones you can consume orally like BPC 157 can be used more often. I have seen many people over use them including many of the Seedlings. Some of those guys pop a few times a day! Time will tell. I think overall most would benefit more from peptide bioregulators over the long term. And save money. Most of his people that I spoke with were also on Rapa.

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#497

Tim, I would be interested in reading the peer reviewed studies the researchers you reference have published.

#498

I have a question about bioregulators, which I tend to distrust. Why has Western science ignored the whole category, when it is deeply invested in peptides? Insulin was patented, but the Supreme Court ruled in 2013 that biological products like peptides must be sufficiently isolated from naturally occurring substances for them to be patenable. Synthetic peptides can probably be patented, but not naturally occurring ones, or some of them anyway. It’s kind of a minefield. Can Russians sue Americans for infringement?

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#499

So you think Jay Campbell is a reliable source because he can troll the internet or read a paper on PubMed? Never mind the internet, which is sprouting new peptide authorities every twenty minutes… Pick any topic on PubMed and you will find countless papers that result in contradictory conclusions.

Dr. Seeds was an experimentalist, much like Dr. Alan Green. Primarily a surgeon, he developed a secondary practice that treated his patients with peptides in order to facilitate healing. Through clinical experience and independent research, he and his medical colleagues acquired a vast knowledge of the field. If you thumb through his book, you’ll see that all his studies, all his recommendations, are backed by hundreds of citations. By comparison, Jay Campbell is an amateur.

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#500

Where have I ever mentioned Jay Campbell? putting words in my mouth is not the best way to go here. Apology accepted :slight_smile:

I’ve repeatedly stated I do not follow influencers.

Had you calmly suggested I read Dr Seeds work would have been better way to go.

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#501

Hi David, below is a link to a review article that should answer all of your questions. Peptide Regulation of Gene Expression: A Systematic Review

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#502

Tim, I am an MD, not an international patent lawyer. I will say that peptide bioregulators are worth a serious look. They are very short amino acid chains that are orally available and can enter the nucleus of a cell. Many of the Seedlings I have spoken with are taking them and find them useful. The thing to remember is that there is no easy way to monetize them since they are made outside of the US. Not just Russia. Compounded peptides create a really nice income stream.

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#503

I do apologize, Steve. You are a great contributor to this thread and you didn’t need a lecture from me.

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#504

Sleepdoc,

You’ve provided a clear, concise and compelling summary, the kind I always like to read. As others have asked or may ask, will you be able to provide some more detail about improvements you, your friends or you mom have experienced and the protocols they’ve used to achieve results. In my case I am interested in eye improvement, better sleep, better energy levels, better digestive health and the list grows as I age. Of course, I know you don’t have time to tell about everything, but a few examples with precise details of protocols would be greatly appreciated. Otherwise, it’s a nice story about successes, but without adequate depth to make it useful for me.

Thanks,
Jay

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#505

Agreed- and might I also add a request to post buying sources. Thank you :blush:

#506

Income stream for who? if you don’t mind me asking. Thanks,

#507

Yes, but not Dr. Seeds himself, who doesn’t so much as mention them in his book. If they were what they’re claimed to be, they would represent a rich and fertile field for research, much like peptides themselves, but no one in Western science goes anywhere near them. Naturally Big Pharma would have no altruistic interest, but there are always maverick investigators in university and independent labs who should be all over this. That they are not is an indictment in itself.

Bioregulators remind me of the goat gonad surgeries done in the early 20th Century that were supposed to reinvigorate those who had the animal’s testicles implanted into their own. The treatment was wildly popular. No less a personage than W.B. Yeats had it done.

They also remind me of homeopathic remedies, based on the principle that “like heals like.” This is placebo medicine. It isn’t backed by scientific studies and yet remains a worldwide, billion-dollar business.

In my opinion, Putin discovered that Khavinson was a fraud, at least concerning some of his results. Putin and his friends were probably taking these substances for years and found them to be no better than placebo. Maybe a little torture applied by the KGB to some of Khavinson’s colleagues gave Putin the information he wanted.

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#508

I’m always open to learn, appreciate that you contribute as well.

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#509

The most decisive difference between peptides and bioregulators is that the latter are consumed orally in capsules, which are then exposed to the digestive system. CosmicNootropics, a leading purveyor of bioregulators, says that these products, consisting of only two or three amino acids, are so small that they don’t break down during the digestive process. Unfortunately, that isn’t true.

According to the book Nutrition Science, small polypeptides such as bioregulators survive until they enter the enterocytes in the small intestine. Once there, they are broken down into single amino acids and then released into the bloodstream. In other words, they cease to exist as bioregulators.

https://openoregon.pressbooks.pub/nutritionscience/chapter/6d-protein-digestion-absorption/

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#510

Small peptides can in fact be absorbed and utilized intact, despite what the nutrition textbook says. Collagen peptides are an example (see PubMed or do a quick AI search for the relevant studies). So in theory, this could be the case with small bioregulator peptides, although I haven’t seen any evidence on their absorption specifically.

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#511

You may be right, Dave, but I found this paragraph illuminating.

“The Digestive Process: How Collagen is Broken Down:
When collagen is ingested, it goes through the digestive process, starting in the stomach. Stomach acid and enzymes begin the breakdown of collagen into smaller protein fragments called peptides. These peptides then move into the small intestine, where further digestion occurs, facilitated by enzymes released by the pancreas. The end result is the breakdown of collagen into individual amino acids, which can be absorbed by the intestinal lining and enter the bloodstream.”

1 Like