#512

On the other hand, I found this, which makes absorption of bioregulators seem at least plausible.

“Previously, it was assumed that CH (hydrolyzed collagen) are fully broken down into single AAs during absorption into the blood stream, serving primarily as building blocks for protein synthesis. However, recent studies confirm that both free AAs and bioactive di- and tripeptides appear in the human bloodstream after CH ingestion.”

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#513

“ In my opinion, Putin discovered that Khavinson was a fraud, at least concerning some of his results. Putin and his friends were probably taking these substances for years and found them to be no better than placebo. Maybe a little torture applied by the KGB to some of Khavinson’s colleagues gave Putin the information he wanted.”

A fine example of Russophobic claptrap.

As anyone with eyes that function can see, the Russian President is in fine health, both physically and mentally. Just last week he sat in front of a live audience and fielded questions for 3-4 hours. He does this quite often. The BRICS conference at Kazan was another example.
He is in stark contrast to the American President, who seems incapable of answering more than 2 questions with more than monosyllabic replies.

But don’t let the facts get in the way of Russophobia…

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#514

Please don’t get me wrong on this, but I am pointing out that physicians make money prescribing peptides For instance a patient goes to a physician who puts him or her on compounded peptides. The physician benefits from more frequent office visits, the pharmacy profits, and the lab generates more income. This is not a bad thing. The patient benefits from the physician’s experience and supervision. But it is an income stream for many people and may explain partially why some therapeutic options are less popular.

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#515

On a side note, does anyone have Dr Seeds’ book or access to his Mots-C protocol? I’m wondering if he talks about WHY he recommends a 3x weekly dose of Mots rather than (for instance) a smaller daily dose prior to exercise? Thanks in advance!

#516

I think there are more than 1 benefit related to MOTS-c, the possible workout enhancer as you have noted and several others.

While the half-life of endogenous MOTS-c is fairly short at about 3 hours, there are several physiological production paths, stress being the primary one. Exercise is stress so we produce MOTS-c as a result of exercise. Whether adding it in before exercise is of benefit, I don’t think, is fully understood though.

We take “low dose” (500mcg) every morning for other reasons.

Exercise

Exercise increases the levels of MOTS-c in skeletal muscle and circulating in plasma.

  • Stress

MOTS-c is expressed in response to stress and is translocated to the nucleus to regulate stress adaptation genes.

MOTS-c plays a role in many physiological processes, including:

  • Energy metabolism

MOTS-c increases AICAR levels and activates AMPK, which influences energy metabolism.

  • Bone metabolism

MOTS-c promotes osteoblast proliferation and differentiation, and inhibits osteoclast production.

  • Insulin sensitivity

MOTS-c increases insulin sensitivity in skeletal muscle.

  • Skin aging

MOTS-c may prevent skin aging by reducing inflammation and increasing dermal collagen.

  • Nonalcoholic steatohepatitis (NASH)

MOTS-c may alleviate NASH-induced liver steatosis, inflammation, and fibrosis.

MOTS-c may also be a potential target for treating other diseases, such as: obesity, cardiovascular disease, and aging

MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism

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#518

Steve, how’d you come up with the 500mcg dose? If you had an unlimited supply of Mots, would you take higher dose and/or more frequently?

#519

I have an unlimited supply, just not an unlimited budget :slight_smile:

I did the high dose thing 12 times 30 minutes before a workout, never noticed much of anything. Keep in mind the 3hr half-life, it doesn’t change with dose size but the peak will be higher and there will be more AUC and then… it’s gone.

Since there are hardly any real studies on exogenous dynamics of “research” peptides, without good measurements, I feel it’s still a bit of a crap shoot :slight_smile:

I’m sure that with some tweaking of the peptide structure it could be made to have a longer half life but then it would need a LOT more testing for potential downside just to be sure. Due to that I don’t see any company wanting to invest in something like this unless they had a way to protect that investment.

I did a month of 1mg daily with my morning stack but after a bit more reading and budgeting, I settled on 500mcg daily. Again it’s a 3hr half life, lower peak and lower area under the curve.

I’ll keep on reading on this one as it appears to have the potential for some interesting benefits.

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#520

No, you’re right. Putin’s a great humanitarian–just like Bryan Johnson.

#521

The book is posted in this thread, maybe even twice, courtesy of Kevin Bradley. Look up “Peptide Protocols” in the search function.

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#522

Jay, thanks for your kind words.

Five years ago I injured my neck and right scapula in a ski crash. Really jacked me up. Just couldn’t get better despite PT and everything else I tried. Became a chronic pain issue. I was working at the time so I just lived with it. When I retired a couple of years ago I decided to do everything possible to improve my overall health and decrease the chronic pain. I have a history of many sports related injuries. Also lots of toxicant (not drugs) exposure and sleep deprivation from my work as an anesthesiologist. High stress.

About 2 years ago I started on a bunch of different peptides, and got some relief but it didn’t last. Probably waited too long. About a year ago a fellow MD sent me a link to a video about bioregulators. Spent a bunch of hours reviewing the data and decided to try them out.

First I did a one month loading dose of Endoluten (pineal), Vladonix (thymus), and Ventifort. ( blood vessel). This was 1 cap of each, twice a day on an empty stomach. These are foundational. The " Big Three". I didn’t notice anything for a couple of weeks. First sign of a change was a very obvious increase in muscle mass which started at about week 3. Embarrassingly, my wife kept catching me looking at my biceps in the mirror. Moderate reduction in morning aches and pains the week after. Slightly improved sleep, energy and mental clarity.

The second month I added a loading dose of Sigumir (bone and cartilage), Cerluten (brain), and continued with the big three for the first ten days of each month thereafter. Was hitting these hard to get a maximal effect.

On the second ten days of month 2, I added Visoluten (eyes) and Libidon (prostate) as a loading dose. At this point I was taking 2 caps daily of Visoluten, Libidon, Sigumir, and Cerluten.

In the following month I kept the big three going and cycled in a bunch of the others which continued over time.

The rationale for the above is that the big three provide an overall longevity effect by boosting hormones, immune, and vascular function. These support all organs so are therefore core bioregulators. They have been shown to lengthen telemeres and improve methylation profiles.

Sigumir was added to help heal injuries and for overall soft tissue support. The Cerluten was to help my aging brain. Visoluten to help with night vision. libidon for prostate support.

Specific targeting is possible because the compounds are actually modified tissue extracts from one year old calf organs. They are able to penetrate the nuclei of their associated tissue type and cause that target tissue to express more youthful proteins. This helps restore homeostasis in aging tissue. This is in opposition to most other peptides which have more short lived general cell receptor mediated effects. Also useful.

The effects from loading dose can last 3-5 months. Basically can just reload every 3-5 months or take them 10 consecutive days each month. There is likely not a need for a washout period since the body does not habituate to these compounds like it does with most peptides. Since they are natural, they are not antigenic.

Peptide bioregulators work very well in conjunction with other peptides. so they are not mutually exclusive. Most of them can be taken orally, SQ or IV. You can take up to five on any one day.

Biggest changes I have noticed are improvements in body composition, endurance and coordination, chronic pain, night vision, urinary urgency, mental clarity, mood, libido, and overall well being.

Hope this helps.

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#523

I have a similar approach but I’ve only been going for a few months and I have not yet noticed any measurable effects, positive or negative. I presume you are using an oral regime? Are you also taking Rapa?

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#524

Jazzmann, yes on the oral regime. Was doing Rapa 6mg with pulsed synolyitcs and enzymes every 2 weeks when I started. Just switched to 6mg weekly.

Most people I know had some effects by month four but not all. My experience was unusual with changes in the first month. May of had something to do with all the other stuff I was doing and lots of symptoms to track.

The core bioregulators, which you are taking, work on improving overall hormone, immune and vascular function. This of course spills over across all body functions. Improvements may be more subtle like fewer colds, lower blood pressure, longer telemeres, better methylation profiles etc. And of course life extension.

Most of the symptomatic improvements I have seen were from using tissue specific bioregulators. Like libidon for urinary frequency. I have a couple of friends that went from peeing a few times at night to zero. It took them a couple of months for that result. Have seen some huge changes including a 28 year old male who had a profound reduction in depression, major sleep improvements, and a huge increase in libido. He also reported a major increase in the ease of muscle growth and lost a lot of body fat. His results were from just the big three.

Another friend said he didn’t notice much change but I noticed his very significant tremor was gone after a couple of months. Just happened gradually so it didn’t register.

Some of the studies on these actually cycle people through all of the different bioregulators each year in addition to the big three. When I reviewed some of the original studies from Russia, a year or so ago, the data looked way to good to be true. But many of these results however have been replicated in ongoing studies in the USA.

Personally I am taking the big 3 for life extension and overall health much like Rapamycin. Trusting the data. Hoping the combination makes me an infant again!

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#525

Thanks Sleepdoc. Who’s peptide products have you used, are you you using? And what do you use for sleeping? :slight_smile:

#526

Hey Jazzmann, Not using peptides currently but in the past got them from compounding pharmacies. Bioregulators gradually replaced the need for the peptides. Would still take them for any acute symptoms.

Other physicians have told me patients have had good luck with Peptide Sciences and Core Peptides. This is not a recommendation. They both have COAs for their products, or did when I last looked.

Sleep can be the tricky one. My sleep has been lousy for a long time from many years of night call. None of the peptides I tried were of much help. The bioregulators helped quite a bit.

For the last week and a half, my sleep has been blissful. Started taking 8gms of glycine, 8gms of NAC and 8 gms of natural calm just before bed. What a difference! In the rare event I wake up in the middle of the night, and can’t return to sleep I take 2 tabs of tranquil sleep with 20mg of melatonin.

The above is in conjunction with eating early, blue blockers for night reading, and avoiding any stimulating electronics after 7pm. No exercise after 4 pm has also helped.

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#527

How much is that costing you a year? Seems like a lot of money.

I get the same benefit from peptides that you get from bioregulators. Peptides worked very quickly for me. At a fraction of the price.

How do you know these tissue extracts aren’t broken down in the digestive system? There is evidence that some peptides, or some unknown portion of the dose, can be detected post-digestion in the blood.

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#528

Not very informed about either, you are saying peptides are cheaper than bioregulators?
And do you mind sharing some you do and the cost/source? Thanks,

#529

Have you ever come across somebody getting anhedonia from BP-157? Two members of this forum report this.having happened to them.

#530

No, and I’d anticipate the opposite with this agent as it drives up BDNF. However, everyone is different.

Vera-Health.ai says the following on this topic:
BPC-157, a synthetic peptide derived from a protein in human gastric juice, has been studied for its potential therapeutic effects on various bodily systems, including the central nervous system (CNS). While specific research directly linking BPC-157 to the treatment of anhedonia—a symptom characterized by a reduced ability to experience pleasure—is limited, there are some theoretical connections based on its broader pharmacological actions.

BPC-157 has been shown to interact with serotonergic and dopaminergic systems 1. These neurotransmitter systems are crucial in regulating mood and emotional responses, and their dysfunction is often associated with anhedonia. By potentially modulating these pathways, BPC-157 might influence mood disorders, including symptoms like anhedonia.

Additionally, BPC-157 exhibits anxiolytic, anticonvulsive, and antidepressant effects, and it has been noted to counteract symptoms modeled after schizophrenia 2. These effects suggest that BPC-157 could impact various behavioral disturbances, potentially including anhedonia. Its ability to exert protective effects on the brain and peripheral tissues further supports its potential as a therapeutic agent for mood-related disorders.

Despite these promising aspects, it is important to emphasize that the evidence is primarily based on preclinical studies and animal models. Clinical studies specifically targeting anhedonia are necessary to confirm these potential benefits. The current understanding of BPC-157’s effects on mood and emotional responses is still evolving, and further research is essential to elucidate its mechanisms and efficacy in treating anhedonia specifically.

In summary, while BPC-157 shows potential in influencing neurotransmitter systems related to mood regulation, direct evidence supporting its use for anhedonia is limited. More clinical research is needed to establish its role in treating this condition.

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#531

I had heart palpitations and tachycardia the first time I tried BPC-157. I thought maybe it was just a fluke since that reaction didn’t make sense to me, so I repeated at a half dose(50 or maybe 100 ug) a few days later and got the same reaction. I threw it away and will never touch the stuff again. Since then, I’ve also seen some other reports on Reddit from others who have had a similar reaction, but it still appears to be extremely rare given the popularity and wide use of this peptide.

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#532

I buy peptides from China, which are the same, relabeled peptides available from domestic vendors, except they are much cheaper buying directly. I know of two sources for bioregulators, CosmicNootropics and Rupharma.com, but there are probably many more.

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