#8

My father’s ApoB went from 130 to 65. I think the higher the starting number, the bigger the impact.

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#9

Your apoB is 48 but you want it lower? Can I ask why?

1 Like
#10

Mainly because my Lp(a) is high, in the 190 nmol/L range. I’d like to get ApoB into the 20-30 mg/dL to reduce residual risk.

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#11

Right. Good luck. Listen to this guy. He seems to have more tools in the bag than most.

https://drtwyman.com/

1 Like
#12

You should probably consider a PCSK9i to get that Lp(a) down a bit as well if you can eat the cost, like 150 mg praluent one time every month. I would look into niacin as well.

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#13

I thought there was no point to doing niacin since it doesn’t reduce deaths or ischemic events. Are you aware of any updated info on niacin, or are there other reasons to doubt the conclusion about death and ischemic events?

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#14

I think those datasets looked at patients in general and no one had looked at in cases of high Lp(a) in general - so might still be helpful for high Lp(a) person where there is more to gain on the benefit side of the equation

And within high Lp(a) there seems to be genetically good vs bad responders from a Lp(a) lowering perspective from niacin - do not think there is any clinical knowledge of hard outcomes data in those groups

These threads and some of the ones above and below them might be helpful

1 Like
#15

I have read – sorry cannot remember where – that the risks of high Lp(a) can be lowered if inflammation is low. If you have not had a C Reactive Protein test, you might consider that, and then do everything you can to reduce inflammation. Which is: all the usual recommendations – limit alcohol, vigorous exercise, avoid inflammatory foods/follow a plant forward diet, and cultivate good sleep.

3 Likes
#16

@Radiata and @Deborah_Hall - somewhat related there is evidence that aspirin can help in Lp(a) cases (though depending on age, etc there may be other risks with that)

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#17

I did not know this.

“Aspirin lowered serum Lp(a) concentrations to approximately 80% of the baseline values in patients with high Lp(a) concentrations (>300 mg/L).”

“aspirin use was associated with a significant reduction in cardiovascular events in carriers of genetic polymorphisms associated with elevated Lp(a) levels. Further studies are needed, however, as these studies focused on narrower subsets of the overall population and genetic markers.”

6 Likes
#18

Thanks, interesting. Aspirin is an anti-inflammatory.

#19

Thank you. I was not aware that aspirin can reduce Lp(a). I have yet to test my Lp(a) for the first time, putting it off because my CRP is in the area of 0.31.

Possible related and purely anecdotal, my wife has been experiencing what she is diagnosing broadly as connective tissue inflammation following relatively light dumbbell workouts and even some yoga routines. She does each three times a week on alternate days. The pain typically occurs with a one-day delay and can be severe enough to sap her energy. She has tried conventional nutritional interventions including curcumin and ginger, along with her already generally low inflammation diet. After six months, she added ibuprofen 200 mg, 2/day and got partial relief. A friend suggested substituting whole turmeric for the refined cucrumin. She added 1/2 to 1 tsp to her morning smoothie and the same amount in the evening in cup of hot water with a little honey. Within 48 hours, the pain was completely gone and has not returned unless her routine pushes a new boundary. She has considered the known variables in her routine and unrefined tumeric is the only plausible candidate at this point. Time will tell but I thought her observation worth sharing.

3 Likes
#20

No side effects from bempedoic acid here after a couple of months.

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#21

Are you still used PCSK9i also? What have you Apo B (or LDL) effects been?

#22

Yes, taking Repatha and ezetimibe as well as the BA. Haven’t had my lipids checked since the last time I mentioned it (ApoB and LDL very low, Lp(a) high)

3 Likes
#23

Update in case anyone is interested:

After increasing my rosuvastatin dose for 3 months from 5 to 20 mg, I saw a decrease in my LDLc of 9 points down to 33 mg/dL, but my ApoB stayed relatively constant at 44 compared to 48 mg/dL. Since statins have been reported to increase Lp(a), I figured I’d test it again, but as you can see it’s stable over time. I feel like I’ve hit a wall trying to lower it, even with Bempa-EZ + max statin. I tried niacin at low doses of only 100 mg, but got bad stomach pains so stopped.

I was glad that my HbA1C didn’t increase at the higher dose. I tested insulin at the suggestion of @AnUser, and found it to be a little on the low side, 2.2 uIU/mL compared to the reference range on the paperwork of 2.6-24.9. I haven’t done any glucose checks lately, but fasting and post-meal levels were always in the 75-120 range while taking a flozin.

blood update1

2 Likes
#24

It looks like only a PCSK9 inhibitor would decrease your Lp(a) and apoB. You’ve already max on impacting LDL via synthesis and absorption. With a PCSK9 inhibitor I don’t think you need to use higher dose statin and bempedoic acid, but not medical advice.

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#25

This de facto race to the bottom we are observing makes me wonder if we will not later learn of adverse consequences from having excessively low levels of various blood lipids. How certain are we, for example, that ultra low LDL levels are beneficial in all cases, especially with respect to levels that can only be reached with medication? If this turns out to be the case, then mother nature has committed a giant screwup. Given that almost all of the medical research in the last 50 to 75 years has been on the consequences of elevated blood lipids, we know very little about life at the other end of the scales.

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#26

Not the first time and certainly not the last. See: balding, aging, cancer, alzheimers disease, …
The leading hypothesis for why humans suffer from cardiovascular disease at such high rates is that higher LDL could be beneficial in famines of which there were many in the past. Nowadays, the average person could not eat anything for 3 months and still be at the upper end of normal weight.

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#27

True enough on mother nature but when compared with the screw-ups on human medical advocacy over any 25 year period, the screw-ups are much more likely to be the result of errors in human judgment. It remains true that we possess scant data on the mid-and long term effects of ultra low TC, LDL-C, Apo(b), etc. We have growing data suggesting that lower is better but we don’t know what that benefit curve looks like from the low normal level on down.

3 Likes