#161

How are you able to dose sirolimus and HGH in a way that does not counteract each other in their effects on mTOR1?

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#162

I take Rapamycin on Friday nights. I take HGH Mon-Fri. My thinking is that there are two days after I take Rapa where I’m not stimulating anabolic pathways. I don’t know if it matters or not but that’s my thinking.

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#163

I thought HGH goes counter to RAPA. In other words it is not recommended for longevity?

#164

For quite a few years I was in an approved clinical trial that allowed me access to HGH. When HGH became so expensive and the publications of Blagosklonny became widely known, I stopped. Now with the work of Fahy and the TRIIM trials, and the issue of thymus regeneration, it seems worth revisiting.

My thinking is similar in that I want my rapamycin Cmax as high as possible, but after a couple of days I’m ready to chase it down with supplements or actions that are antagonistic to its effects. I doubt that the AUC is as important as the Cmax but I have no evidence to support my opinion.

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#165

Another potential supplement:

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#166

Looks like cacao is the best single source. Otherwise eat a lot of plants to get enough. Or take a pill, I guess.

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#167

Very useful, thank you. Thinking about supplement stack reduction… Thought it would be useful to think about how to achieve these without using supplements.

Glycine : 300g red meat, 400g salmon, or 400g of peanuts = 6g of glycine *other amino acids may impact utilization?
Magnesium : 38 g of pumpkins seeds, 29g chia, 37g of almonds each = 100mg magnesium *seems doable?
Fish Oil-Omega 3 : 300g salmon/sardines per week = 1000 mg omega 3 per day *seems doable, but mercury?
Taurine : 200g scallops or 400g of mussels = 2g taurine. *very difficult
Vitamin D3 : 9 to 46 minutes in the sun = 1000 iu *cancer risk *Estimation of exposure durations for vitamin D production and sunburn risk in Switzerland - PubMed

My conclusion having done that is to primarily rely on food (sushi and sardines) for omega 3, and (seeds and nuts) magnesium. But keep taking the taurine, glycine and D3

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#168

I would agree with omega 3 being supplied through food as being a great source. I do however think that for most others (including magnesium) supplementing is a good idea. I think that the amounts that come from food may be ok but NOT optimal.

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#169

my hair was mostly white (I’m 70) and now I’m noticing more “salt and pepper”. In my beard, the increased pigmentation is much more noticeable with streaks of dark hair.

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#170

dihydroberberine vs berberine

“These results provide preliminary evidence that four doses of a 100 mg dose of dihydroberberine and 200 mg dose of dihydroberberine produce significantly greater concentrations of plasma berberine across of two-hour measurement window when compared to a 500 mg dose of berberine”

“The lack of observed changes in glucose and insulin were likely due to the short duration of supplementation and insulin responsive nature of study participants”

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#171

Anything is possible, but I really doubt the hair color has anything to do with RAPA. I actually got more white hair during 1.5 years of RAPA but that is to be expected since as you get older you get more white hair. I did however feel that taking some other supplements might have helped a bit, one of them being copper. But then again, I might have been deficient in copper, because if you have enough in your blood, I doubt it will make a difference.

#172

Just wanted to check—is that a typo?

Edit: Scratch that. I just saw your E2/E2 comment!

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#173

Ha! Yep. Not a typo. :rofl:

#174

Thanks Joseph. After a lot of research we chose Dihydroberberine (GlucoVantage) for our longevity supplement box (hopbox.life).

It’s been very well tolerated and anecdotally we’re seeing significant reductions in A1c, fasting glucose and insulin but less GI upset compared to berberine.

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WiseAthletes podcast episode on Heart Health
#175

Here is my current list of Supplements (also take Rapamycin, Metformin, Testosterone cream, Peptide injections)

  1. EFA
  2. VIT D3 2500iu summer 10,000iu winter
  3. Lithium Orotate 10mg
  4. Whole food based Multi
  5. Greens powder
  6. Magnesium Threonate / Bisglycinate alternate
  7. NMN
  8. Quercetin
  9. Resveratrol
  10. Creatine
  11. GlyNac
  12. Low dose Tadalafil
  13. Beta Alanine
  14. Olive Oil pills
  15. Taurine.

Looks like I need to shorten the list a bit. Am I taking too many things ??

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#176

Nice list! No you do not need to shorten your list. I take about 30+ supplements. I probably do need to shorten my list. I started this thread just so we could all get an idea of what supplements we think are most important.

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#177

Instead of olive oil pills, you could just take a shot of EVOO. I mix NMN powder in it along with black pepper and tumeric. NMN powder is also a lot cheaper than pills. You can also mix Resveratrol in it as well. EVOO improves bioavailability of some fat soluble powders as it’s a fat source.

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#178

Conversely, I’ve noticed I have a couple new gray hairs in my eyebrows, I’ve decided to up my Rapa dose from 4 mg (2 years w/no side effects) to 6 mg wkly. Also, head hair is as gray as ever. @ 67 all my blood markers are stellar. Jumped on the methylation gene testing bandwagon, and discovered green tea and Quercetin are not my friends! So many rabbit holes! But worth it.

#179

Great suggestion. I usually use NMN in water to take my AM/no food pills. Since EVOO would break my fast, I’ll try it later in the day.

#180

What specific testing do you do that informed you to avoid green tea and quercetin

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