#181

Both are HDAC inhibitors

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#182

John, I wish you would elaborate a little more on your responses. Many of us here do not understand the medical terminology as you do.
I am confused. Are you saying HDAC inhibition is a bad thing?

"By inhibiting HDACs, these drugs cause increased acetylation of histones, relaxing the chromatin structure and allowing more gene transcription. This can help restore normal gene expression in diseases where HDAC activity is dysregulated.

Several HDAC inhibitors are FDA approved to treat certain types of lymphoma and myeloma. They help reactivate genes that trigger cell cycle arrest, apoptosis, and differentiation in cancer cells.

HDAC inhibitors may help improve cognitive function in Alzheimer’s and other neurodegenerative diseases by enhancing synaptic plasticity and memory formation.

By regulating gene expression, HDAC inhibitors have potential as anti-inflammatory agents. They are being studied for diseases like inflammatory bowel disease."

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#183

My Naturopath ordered Methyl Detox Profile through Rupa. They checked MTHFR, MTR, MTRR, AHCY & COMT. A mutation in my COMT nutrient recommendation suggested high does of bioactive food components such as tea catechins (green & black tea, EGCG, green coffee bean extract) & Quercetin may further inhibit COMT enzyme activity. Ceased use of both & my recently developed sleep issues & low-level anxiety were remedied. Also recommended I up my magnesium OrthoMolecular Opti Mag Neuo, B’s need to be methylated, added 5-MTHF & B12. If you’re interested, I’d recommend you look into 3x4 Genetics. They do a pretty thorough deep dive on many gene Nutrigeonomics accompanied by a very helpful diet, supplements, lifestyle recommendations.

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#184

I think HDAC inhibition is a good thing.

One of the substances in royal jelly which enables the queen bee to live as long as she does is an HDAC inhibitor.

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#185

Further on this, if people would like me to do a detailed post about transcription of mRNA and HDAC inhibition I will do it as a separate topic.

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#186

Yes, please do. That would be very helpful.

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#187

As the son of a beekeeper, you definitely caught my attention with this. And, yes the queen bee lives a very long time. Regular bees live a max of 6 months (winter ones) while I remember queen bees living even 5 years (usually 3-4 years, but I think we had some that lived even longer 5-7). So yes give us as much info as possible on the subject.

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#188
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#189

The Termite Queen has a similar long life, but the mechanism is quite different and I am not sure people have entirely worked out how it works.

In essence if you wished to describe my protocol as something intended to be equivalent to Royal Jelly for Homo Sapiens that would not be far wrong.

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#190

Yes please! That would be great

#191

Dr. Gundry has weighed in with his response below.

Interesting that he includes C15 and Urolithin A. The others are kind of your standard D3, K2, Omega 3, magnesium, etc…

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#192

This is the guy the recommends 1/2 liter of olive oil per day, he is buffoon LOL

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#193

I agree with his recommendations in this video. Also, I think a shot of EVOO is not a bad idea especially if you mix in powders to help absorption. But he doesn’t mention that here. Also, he is a medical doctor.

Buffoonery is in the eye of the beholder.

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#194

That sounds a little excessive but I don’t think that that equals buffoonery. A lot of us on this forum would be considered a little excessive.

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#195

I hear ya, and actually I think he has some very good suggestions regarding nutrition but he lost me when I heard him say that we should be consuming 1L of olive oil in 3-5 days, no dude that is buffoonery at its best lol. I would have been fine with 3-5 spoons per day, but 1/2 a liter a day, seriously?

btw, I always consume organic olive oil daily, but max probably 50mg (3-5 spoons). I always break my fast/start my day with a shot of about one OZ of olive oil (organic btw)

#196

Just watched the video and so do I. A valuable tip I picked up from both AnUser and Neo here is to increase the speed of the video (and they don’t sound like chipmunks). In this case increasing the speed to 1.5x made him sound almost normal (he’s a slow talker). Not sure I would put C15 or Urolithin A in my top 10 (mainly because I’m not rich) but they could turn out to be that important. My recent cycling on/off with NMN has led me to believe that a NAD precursor (for me) should be in the top 10. I’ll experiment with the different forms. And I liked the use of the flash cards!

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#197

OK, here’s my top 10 (and yes it’s a lot of the same stuff)

  1. A good multi-vitamin (haven’t found the perfect one yet) that would include a good dose of the B vitamins, Vitamin C and ideally Vit D/K too.
  2. Vitamin D3/K2 (MK4+MK7)
  3. Omega 3 - EPA/DHA
  4. Magnesium
  5. Glucosamine (can feel it in my knee joints)
  6. Collagen (glycine + other benefits)
  7. Creatine - and -
  8. Whey Protein Powder ( both for muscles and fitness)
  9. NAD precursor
  10. Metformin - because it’s so cheap and available, I feel no side effects (even on building muscles or HIIT exercise) AND I think the science is strong for benefit. I take 850mg at night on the theory of that’s your fasting cycle and it might give you more CR benefits. I generally follow time restricted eating and have a low calorie, low carb diet so metformin for glucose control for meals might be less important. I do try to get enough protein to build muscle.
    ***** And I would add extra Glycine and NAC (but well separated from when I take Glucosamine). Also I think AKG is very important until I start Rapamycin.
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#198

Nice list!

Can you explain why keeping glycine and NAC separate from glucosamine is important? And, why AKG is not important if you take rapamycin?

#199

There’s evidence that NAC interferes with Glucosamine. It’s been cited here before but:
" Antioxidants prevent GlcN-mediated life span extension

This indicates that the transient increase in ROS is required for the extension of life span caused by GlcN, thus providing additional support for adaptive ROS signalling or mitohormesis or both. Although neither BHA nor NAC had a detectable effect on C. elegans life span in the absence of GlcN, the life span-extending capabilities of GlcN were nullified in the presence of BHA or NAC."
https://www.nature.com/articles/ncomms4563
As for AKG, see my post here:
https://spotify.localizer.co/t/anyone-taking-calcium-alpha-ketoglutarate-akg/327/65?u=ng0rge

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#200

These would be the 10 supplements I would choose:

  1. Magnesium L-Threonate
  2. Vitamin D
  3. Boron
  4. N-Acetyl Glucosamine
  5. Quercetin
  6. Indole 3 Carbinol
  7. Vitamin B Complex
  8. Pomegranate Extract
  9. Palmitoylethanolamide
  10. Ginger (as needed)

Gut health is key in my experience and this stack addresses it.

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