Thank you, @DeStrider , for the update I look forward to your “official” n=3 update on GlyNAC effectiveness in August after another round of blood tests.
I’m curious as a number of us have been taking GlyNAC for months now: Is anyone seeing actual benefits/improvements from GlyNAC supplementation? I seem to remember someone in this post is seeing superhuman grip strength improvements. Any comments on its impact are appreciated.
I ask because I’ve been taking a “conservative” (lower) dose and see zero improvement thus far I’m taking 3g glycine in my morning coffee and then 50mg NACET (which could be between 500mg to 1g NAC equivalent depending who you believe) with the coffee for four months and nada. I’m definitely not seeing grip strength improvements, and this would help as I’m on a muscle-building heavy-lifting exercise regime since early January 2023: my grip fails before my other muscles seem to. My wife is taking it as well and hasn’t mentioned anything (we’re hoping it will help some retina issues).
I just bumped up to 100mg NACET daily (likely between 1-2g) with the 3g glycine. I’ll let you know what I see but getting less optimistic on this. Maybe I’m not old enough? — I’m 52 and reasonably fit and exercise hard, as well as being on keto (carnivore since early Jan to build muscle). So I may be confounding the impact GlyNAC could have. Assuming nothing bad happens to be over the next several months I plan to bump the NACET up again (to 200mg NACET daily) and doubling glycine to 6g daily.
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Bicep
#145
The point of GlyNac as explained by Lustgarten is that as we age we make less glutathione, also CD38 goes up and…biochemistry and age conspire.
You sound like you might not be old enough to be in need yet. Just a guess. When I took it there was a definite difference, but as I explained elsewhere the NAC can have effects on the heart. I’m pretty sure that’s what happened to me. I’ve increased the glycine to 10gm/day and seldom take NAC now.
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It seems to help me sleep better, especially when taken in combination with magnesium. N=1
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Goran
#147
This is an excellent video about GlyNAC supplementation.
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Yes this is true- glutathione, but hypothetically speaking the authors propose 3 primary reasons-
" 4.4. Why GlyNAC Works—The ‘Power of Three"
Furthermore, NAC influences mTOR- I think there is more at play here.
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A recent article about the many benefits of glycine supplementation in addition to extending lifespan. What I like about glycine is that it is cheap, easily bioavailable, and doesn’t taste bad.
Michael Lustgarten Ph.D. seems to think maybe 2 grams/day is optimum, but I haven’t seen his results yet.
“The simple amino acid glycine extends lifespan in worms, mice, and rats”
“The most compelling evidence for glycine as a pro-longevity molecule comes from the National Institute on Aging’s Interventions Testing Program, which collects lifespan data in genetically heterogeneous mice across three distinct geographical sites”
“In a more recent investigation, treating mice with both glycine and N-acetyl cysteine led to a 23.4% mean lifespan increase in females and a 24.2% mean lifespan increase in males”
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Neo
#150
Interesting that the focus is more on the calorie/protein/methionine restriction story and not really on the antioxidant/glutathione story:
*The simple amino acid glycine extends lifespan in worms, mice, and rats
*Glycine also improves aspects of health in mammalian models of age-related disease
*Glycine is the acceptor for GNMT, an enzyme responsible for methionine clearance
*GNMT also converts glycine to sarcosine, an autophagy-inducing metabolite
*Glycine may prolong life by inducing autophagy and mimicking methionine restriction
And interesting how there is some support across multiple types of animals so spans evolution quite well.
Also of note is that all authors are Tally Health employees (Sinclair’s recent company discussed elsewhere here in context of their biological age test). They don’t have glycine in their product yet, but perhaps that or a standalone new product is in the works.
Just because Sinclair supports something doesn’t mean it is without merit. The ITP and Baylor have independently proven the life extending effects of glycine. However to get the large 20%+ increase in life expectancy, you need to pair glycine with cysteine or NAC.
Some have been worried that NAC is carcinogenic due to its antioxidant properties, but I would argue if that was the case, then the mice in the Baylor study taking glycine and NAC wouldn’t have lived 20% longer as mice are prone to cancer. Also, there were two additional studies - one that showed NAC was neutral towards cancer and another that it was protective against cancer.
I think the problem is when you take NAC without glycine and vice versa as both are needed to metabolize glutamine and produce GSH. Glutamine is also a fuel for cancer and if it is not converted to GSH, it builds up in your body as you age.
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An interesting Estonian Youtuber who seems to know what he is talking about refreshed my memory as to why I take 6-10 grams of glycine every day. This guy has very impressive genetics or he is doing something right. If you watch his videos you will see he is extremely fit, unlike many health gurus. “He is an anthropologist. He creates content about biohacking, health, and optimal performance.”
Glycine is one of the more proven life-extension supplements.
Glycine supplementation is especially important to those of us who eat a lot or dairy products and meat that contain methionine.
“As mentioned earlier glycine is the one amino acid studied thus far in which supplementation has been shown to extend the lifespan of mice, albeit moderately”
“Dietary glycine supplementation also extended the lifespan of Fisher 344 rats through a mechanism mimicking methionine restriction”
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Vlasko
#153
A new Glynac study in mice. The title sums up the findings: “GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Old Mice Improves Brain Glutathione Deficiency, Oxidative Stress, Glucose Uptake, Mitochondrial Dysfunction, Genomic Damage, Inflammation and Neurotrophic Factors to Reverse Age-Associated Cognitive Decline: Implications for Improving Brain Health in Aging”
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In this video, Lance recommends a daily glycine dose of between 10-36 g daily. He recommends about 3-4 g of NAC daily.
He also references a study where participants took 80 g daily with no bad side effects. That’s a ton of glycine!!!
Buy the bulk powders for cost effectiveness if you go this route.
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That’s a lot of glycine. I have upped my daily dose to about 12 -15 grams by putting some in my Greek yogurt. It improves the taste for me as I am not really fond of plain Greek yogurt, but I do think it is a healthy food.
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Rapamycin is an inhibitor of mtor, and glycine is an activator of mtor. The two are contradictory to each other. I did not take glycine for three days after taking rapamycin, and only took glycine for the next four days. I want to know how everyone handles them
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Goran
#157
Thats a great argument. I just investigated this, and you seem to be correct. I will try to stay away from Glycine on my Rapa day (Sunday) and Monday/Tuesday.
Taurine seems to inhibit Mtor though, So I will continue taking that everyday.
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Goran
#158
NAC blocks Mtor activity as well, so that is interesting.
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Curious
#159
I have found that NAC inhibits mTOR in some cells. But I have not learned that NAC has a general inhibitory effect. It might have, but human biology is really complex.
So I dont want to draw general conclusions, but try to stay specific.
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Glycine may activate MTOR, but Rapa binds to the receptors and blocks it completely. Glycine can’t override that block as far as I know.
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So glycine would be useless for this specific pathway, but potentially beneficial beneficial in other pathways? So ok to take with Rapamycin?
This is interesting. I’m now thinking I should stop everything in the 48 hours around rapa dose. It would also be good for my addictive tendencies.
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And possibly fast as well to alleviate your glucose spikes?
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