pollux
#124
i take 100 mg lipmaxmall N-Acetyl Cysteine Ethyl Ester (NACET) pill plus one pill of 1000 mg Glycine per day.
“Studies have shown that NACET has much higher bioavailability (around 60%) than NAC.”
Piperine increases the bioavailability of NAC. Maybe even more than 60%.
So, just take some piperine with your NAC it’s a lot cheaper.
“some studies have shown that piperine can increase the bioavailability of NAC by up to 2-fold”
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@desertshores How do you get your piperine? Just add crushed black pepper or an actual supplement?
1g of glycine daily seems quite low. I think you need 3-6 g. You need about 1.75X as much glycine as NAC according to the study above.
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I use Source Naturals, but I don’t claim it’s any better than any other brand.
https://www.amazon.com/s?k=Source-Naturals-BioPerine-Piperine-Supplement%2F
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CTStan
#128
I cant find any support for improved bioavailability of NAC by piperine. Can you locate the reference?
Goran
#129
I believe NAC is water soluble, so it should not be an issue with bioavailability. However it is classified as an amino acid I believe, so it should not compete with protein. So take it 2 hours before or after a meal. I think I remember I read this somewhere, google it to get confirmation.
CTStan
#130
That makes sense that you dont want it to just combine with other amino acids to build protein. But on an empty stomach I find it hard to tolerate.
Maybe the NACET avoids that problem. The dosage instructions dont indicate the need to take on an empty stomach.
As far as I can tell from reading the literature: piperine and grapefruit juice inhibits the liver’s first-pass metabolism of most drugs and supplements. Also, "piperine in the form of 1-piperopiperidine, stimulates thermogenic action in the epithelial cells of the small intestine. This acts as a thermonutrient that allows for increased absorption and bioavailability of the nutrients "
That is why so many supplements are sold with “plus piperine”
I have not seen a specific study involving NAC but I would be very surprised to learn that piperine did not specifically increase the bioavailability of NAC. The increase of 200% is my estimation of the minimum based on looking at what it does for other supplements. For instance:“Piperine has also been known to inhibit CYP3A4 and P-glycoprotein due to which it has been used to enhance the bioavailability of other drugs [10]. When co-administered with curcumin, piperine increased the bioavailability of curcumin by 2000%”
“Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.”
CYP3A4 is a major enzyme in the human body involved in the metabolism of many drugs and other substances.
"Bioperine® has been administered together with vitamins, minerals, and some nutrients (Table 2; extracted from Majeed M et al. [42]) as a bioavailability enhancer "
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353321/
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“NAC has low bioavailability as an oral supplement, meaning that your body does not absorb it well”
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Vlasko
#134
It’s not just a question of absorption from the gut. It’s how readily it’s taken up by cells and how efficiently it replenishes glutathione. And per the study I cited to earlier, NACET did all of this more efficiently. And it’s affordable now. With that said, the rodent lifespan study used NAC. So I understand why people would want to just stick with that.
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The main reason I take NAC is I have a large supply of it from hoarding it when I was afraid it was going to be taken off of the market.
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I think those figures should be divided by 1000. No one can take 6,000 grams daily! But 6 grams is what I expected.
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Lol 
that’s why I take it too
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Yes! 5,990g=5990mg and 5,888g=5888mg. It’s a very big dose, any way! And I weight 60kgr!
If you are about 75kgr the outputs are: 7488mg of glycine and 7360mg of NAC!
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Actually 6g of these supplements are not too bad. Especially the glycine.
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i’m pretty close to that amount of glycine/NAC. For what it’s worth, I believe the researchers were aware that glutathione is available as an alternative but opted instead for glycine and NAC separately. while there is no explanation in their paper, Dr Brad Stanfield has a video saying that it is relatively easy to overdose glutathione supplements but not when you allow the body to make its own from the glycine/NAC stack. FYI Swanson in the US makes a 1000mg NAc capsule so its pretty easy to take 12 gms in four doses over the course of a day.
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Bicep
#141
That amount of NAC can cause issues with heartbeat. I took the full course for 3 months and got afib and spent 3 hours in the ER trying to figure out what was going on. Quit the NAC and it went away. Started just glycine, then added back 1/3 the dose of NAC and had one flutter once, but I’m going to ignore that.
Just FYI
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tananth
#142
The Baylor researchers made that claim about overdosing, but there is no evidence supporting it. But Glutathione supplementation fails to raise levels in most cells: unless cells are highly deficient (eg liver cells after Tylenol poisoning) the density of Glutathione in the blood will never exceed that in any cell, so will never be aborbed by cells by osmosis from blood and there is no pump mechanism to absorb it, since all cells are supposed to synthesize what they need. On the other hand Glycine + NAC can be absorbed by cells and used to increase synthesis of Glutathione. The problem is that as human age the first enzyme in the Glutathione synthesis progressively is present in smaller and smaller quantities (for reasons that are not well understood) and that first stage uses Cysteine (from NAC), so providing more of it will compensate for the lack of synthesis enzyme to some extent but you really need to consume ridiculously high levels of NAC to fully compensate for the lack of enzymes, which can cause many side effects. Glycine is used in the 2nd stage of synthesis where the enzyme is always plentiful, so only lack of Glycine itself can slow down that stage. This can occur for those with a diet lacking in Glycine but is not age related.
A much better solution is to supplement with Glycine + GGC (Gamma Glutamylcystein, the result of the 1st stage of Glutathione synthesis). GGC is readily absorbed by all cells and crosses the BBB easily, since all cells have little GGC present, since it gets converted to Glutathione immediately by the 2nd synthesis stage. So simple osmosis will allow all cells to absorb GGC from the blood and convert it to Glutathione (unless you are deficient in Glycine). Any excess Glutathione is immediately broken down and recycled (with excess amino acid dumped into the blood) so there is no risk of excess accumulating inside cells. In fact, unless you continuously supplement with GGC, after 4-6 hours cellular glutathione levels revert to their age specific deficient levels.
GGC is currently manufactured in quantity only by one company (since Nov 2019) under the brand name Glyteine, www.continualg.com. And it is expensive : a single serving of 400mg costs $1.5, if you subscribe in 90 day increments, and you need at least 2 servings per day, preferably twice that level since benefits are limited to 4-6 hours.
There are some who believe that when large quantities of Glutathione are taken orally, some of it will break down in the digestive tract into GGC + Glycine, which is the only reason Glutathione supplementation is able to raise cellular Glutathione levels. GGC itself is very stable and will not break down further in the digestive tract.
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My mother has had great improvements in her blood sugar levels and diabetes markers after taking NAC + Glycine, so it is working as Baylor claims IMHO. She takes about 2 g of NAC daily (they reduced it), so even at that level, there is a noticeable change. As for Glycine, she takes 2 tbsps daily as well.
I did not know that NAC caused a heart flutter. That could explain the feeling I have sometimes. I take 3.2 g of NAC daily as well as 2 tbsps of Glycine, 1 g of TMG, and 11 g of collagen peptides (about 3.3 g of Glycine) So in total about 7-9 g of Glycine daily.
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