#164

But I would still take metformin for the alleged compounding longevity affect. Still, fasting would be a further boost to mTOR turndown (possibly good) …while also removing my will to live (probably bad).

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#165

I hear you: at this moment I’m halfway through the third day of a four day water/coffee fast and it’s not easy…and I’m headed to the gym to lift now! But I’m convinced my four-day fasts are responsible for a large portion of the health/longevity gains I have made (greater than intermittent fasting and diet alone). So painful as it is, I do it.

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#166

I used to do a 3 day fast every month but lost the edge. I need to find it again. Thanks for the push.

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#167

My father just got his blood glutathione levels back. The normal optimal levels are 373-838 uM. My father’s glutathione level was 945 uM. He takes 1 g of NAC and a tbsp of Glycine daily (4-5 g).

His ApoB is 108
HBA1C is 5.6

He also takes 1 g of Metformin daily.

11 Likes
#169

Another reason to take Glycine and NAC: Glutathione (GSH) is a senomorphic, like Rapamycin, that prevents formation of senescent cells.

NADPH and GSH can hinder senescence by exerting antioxidant function.

Why does everything come back to senescence?

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#170

If if you paid me $1million I would still not take anywhere near that much Glycine (and I do mean it literally). I know many people in here are big fans of it and are taking it in high doses, but I would NEVER do more than 1-2 grams daily. Anecdotal but I’m pretty sure that it was pretty bad when did like 7-8 daily for couple days.
I’m actually doing 1G glycine and 500MCG NAC now, but that is the most I’ll ever do for both.
Didn’t get the LOVE i like to see when I did GLYNAC in high dose. Some of these dudes in the longevity front are kind in a race with each other. One day you hear someone say ok do 1G of something and next day the other says it should be 5grams and before you know it another of these bozos comes and says well it actually should be 50grams LOL.

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#171

That amount of glycine tends to cause a lot of Gasto issues I’ve read, another reason to avoid it.

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#172

When I did glynac in high dose in the morning for couple days, I felt as if I was full in my stomach (in a bad way) all day long even though I hadn’t eaten anything that day till dinner. Weird and bad effect in high dose. A lower dose however doesn’t seem to give that feeling, and I tend to think it is sitting well with my body. So, for me it is way less than this guy suggests.

#173

Holly molly that is a lot of both but especially Glycine. Do you have any side effects? I tried high doses but they were really bad for me. Lowered the dose to about 1G each, and that is ok with my body.

#174

The only side effect I get from Glycine is that I get really sleepy around 10:30 pm and can quickly fall asleep.

2 Likes
#175

How long he has been on the new combination? what improvement he has seen in biomarkers and subjective experiences?

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#176

Other than his glutathione being really high, his HBA1C is not in diabetic levels (He does take 500 mg Metformin daily). Unfortunately, his LDL and APOB are both high. But his glutathione levels are quite high. He goes to the gym 3X a week and subjectively, he feels that he is in great health. He is 76 yo and did have both hips replaced recently. However, he is able to get around and do everything a normal person would do. He doesn’t run a lot, but he can handle an elliptical machine just as well as I can. We’ve suggested that he no longer bikes as his balance is getting a bit bad.

I’ve just started him on creatine and protein powder. We shall see if that helps. He has just started taking Rapamycin 1 mg + GFJ.

3 Likes
#178

Thanks, but we’re going to scale up slowly. :slight_smile:

#179

where is the study for that conclusion?

#180

Well the only study that I’m aware of is the one on mice and that translates into much higher doses than even the highest dose we might be taking. As for the lower dose, all i got from Peter Attia podcast was that you need real high doses to cross the brain barrier, so by default if it doesn’t cross into the brain it might not that beneficial. Just a thought.

#181

I take at least 6g of glycine everyday with zero GI distress. I get no obvious benefit but it does taste good. So there’s that. I am trying hard to boost glutathione for many targeted benefits.

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#182

I believe they have a financial interest but it’s just two amino acids and the number of improved biomarkers is quite amazing.
I believe Nestle sells the combination of NAC/GLY

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#183

the grand dosage based on weight is very high for NAC and Glycine. Dr Green says that’s the amount in a pound and a half of steak.

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#184

Well, when you are only utilizing 20% of the Glycine and NAC you did when you were in your 20s, you have to up your intake to get back to normal levels.

My father takes 1 g of NAC and 4-5 g of Glycine daily. This brings his glutathione levels beyond the high bounds of normal levels. This is a good thing.

1 Like
#185

I think a tablespoon of glycine would be considerably more than 4 to 5 grams. There’s somewhere around 4 grams in a teaspoon. And a tablesoon is three teaspoons.