There is such a thing as “I lost weight” face 
Interestingly our face has a lot of muscle that can be exercised to reduce that look. Just like the rest of our muscle that can diminish in size from losing weight, resistance exercise is the key to maintaining muscle size.
My wife and I both do “facercise” fortunately she looks much better than I
1 Like
cl-user
#286
A (not great) whoop paper on increased HR and lower HRV with GLP1-RA
Heart and Health Behavior Responses to GLP-1 Receptor Agonists: A 12-Week Study Using Wearable Technology and Causal Inference
After the 12-week study period, GLP-1 users showed significant (Ps <0.05) weight loss (-10.0%, 95%CI: -11.2 to -8.5%) and changes in RHR (3.2±0.8bpm) that were mediated (P <0.01) by changes in HRV (-6.2±1.4ms) compared with control.
That conclusion is wrong as lower HRV is bad so it’s not compensating the higher HRV at all and they insist on it:
Our real-world findings align with clinical trial data in showing rapid and significant weight loss with GLP-1 RAs, coinciding with increases in RHR that are mediated by changes in autonomic function (i.e., HRV).
Coming from whoop it’s rather strange they have it backward for the HRV.
LukeMV
#287
It makes me feel full faster. Sometimes when I go out to eat, it’s hard to stop myself. Now I feel like I have more control over it.
1 Like
HRV is not hard to “fix” for those who are concerned about that. I’ve not experienced a drop in HRV and neither has my Boss, probably due to what we do to improve it.
cl-user
#289
I’m very interested in that. As you can see my HRV was not very good to begin with but it crashed when I started the GLP1-RA in December as you can see I’m down to 11ms 
on my Oura ring:
1 Like
adssx
#290
Here’s the HRV optimization guide @cl-user: Hello, my name is Steve and I'm a longevaholic - #5 by Steve_Combi
Make sure you only measure HRV once a day, first thing in the morning, always in the same position.
2 Likes
Looks like you have experienced terrible muscle loss…
Some day I hope to lose muscle like that LoL!
6 Likes
LukeMV
#292
Hah! No I don’t think I have experienced any muscle loss!
1 Like
cl-user
#293
I’ve read it when it was posted (BTW Thank @Steve_Combi) and tried the tVNS but did not see any improvement so stopped it after 10 days or so. I’m going to try again for a longer duration but here I was talking specifically about the HRV crashing when I started the GLP1_RA.
1 Like
adssx
#294
That was a pretty dramatic HRV crash.
It can take 2 to 3 months to see a significant and “sticky” improvement with tVNS. It won’t be an overnight improvement. Mine continued to improve over a 12 month period. During that period it varied significantly from highs to lows BUT the overall trend clearly demonstrates an improvement over time. If you do not give it time, you can’t see the trend.
And by sticky it means that missing a few sessions won’t cause a drop in in the HRV trend.
It’s important to understand that the last letter V (variability) can cause one to stop doing what does work, when the desired result is slow to manifest. Patience, and being consistent over time is the key
This is the same issue with PWV (pulse wave velocity) the improvements take time and during the process, snap shots in time will vary significantly. If people aren’t patient and consistent, they will never see the overall trend nor experience the benefit. This can also be seen in my little PWV PDF.
cl-user
#296
Well I have the same issue with PWV. It was going down but when I started rosuvastatin it went straight up until I added empagliflozin which stopped the rise and improves it a little bit.
3 Likes
RapAdmin
#297
How are you (and others here) getting PWV measured? Where do you go to get this measured? Do we have to go to a specific clinic that does this? or your regular doctor’s office? What approach (where) do you get it measured on your body (it seems there are a number of different options).
How to Measure Arterial Stiffness in Humans
https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.313132
1 Like
cl-user
#298
I use the Body Scan Scale from Withings
Note that in the USA we don’t get the PWV in normal units but instead as a vascular age because of the FDA
4 Likes
cl-user
#299
@RapAdmin I even found an independent paper on it.
Withings Body Cardio Versus Gold Standards of Pulse-Wave Velocity and Body Composition
In conclusion, the Withings’ Body Cardio scale has the potential to improve the arterial health
of consumers by providing accurate assessment of PWV in the home. This information can serve to
motivate individuals to make healthy life style choices as well as offer health care providers the ability
to monitor their patient’s health. Furthermore, this feature offers researchers an inexpensive method
for studying PWV longitudinally in an ecological setting. In contrast, the use of the Body Cardio to
assess percent of body fat must be used with caution as the MAPE is greater than 25%.
2 Likes
RapAdmin
#300
Yes - that was my next question, how accurate would it be…
So far, the Withings Body Cardio scale is the only consumer device that has been designed to measure PWV and body composition, including fat mass (FM) and fat-free mass (FFM), in the home setting.
“Conclusions: The Body Cardio scale provides accurate measures of BM and PWV; however, it should be used cautiously for measures of FM and FFM.”
1 Like
cl-user
#301
Here is my comparison vs DEXA:
|
DEXA |
Body Comp |
| Fat (%) |
18.3 |
7 |
| Visceral Fat (kg) |
0.19 |
1.7 |
Really bad for sure. The visceral fat is off by an order of magnitude!
2 Likes
mccoy
#302
Heck, congrats to the big & ripped look, it is a testimony that intermittent rapamycin use does not compromise muscle hypertrophy at all.
Most probably, it’s an issue of potency of the mechanotransducers signal, of the fact that rapa is not a catalytic inhibitor and last that the intermittent inhibition is maybe useful to regeneration of muscle tissue.
Also, in the context of looking big & ripped, I understand the use of GLP1 inhibitors, you are able to adjust the food intake to exactly the right caloric amount required not to gain excess adiposity.
I’m interested to know if staying long-term in that optimal state is achievable without too extraordinary means or not.
3 Likes
LukeMV
#303
Why thank you. That’s a solid analysis.
I’ve been on Rapamycin every 7-10 days for a few years, most of the time at 5mg per dose and I did experiment with 10mg at one point for several weeks but I saw a higher A1C than I was used to (5.5) so I went back to 5mg and it was back to baseline (5.0).
I definitely don’t think Rapamycin has inhibited any muscle growth or anything, but to be fair, I already had quite a lot of muscle before ever getting on it to begin it.
The GLP1 I’ve been on for five weeks now and yes, I like that I’m not always starving anymore at the low dose I’m using. I tend to go out to eat several nights a week and now I don’t feel like eating everything on the table anymore.
4 Likes
LukeMV
#304
Does anyone have any opinion on this one? From October 2024. They’re saying it’s not clear if there’s a causal link but I’m not sure why this association would occur.
The risk of depression, anxiety, and suicidal behavior in patients with obesity on glucagon like peptide-1 receptor agonist therapy
https://www.nature.com/articles/s41598-024-75965-2
3 Likes
