LukeMV
#304
Does anyone have any opinion on this one? From October 2024. They’re saying it’s not clear if there’s a causal link but I’m not sure why this association would occur.
The risk of depression, anxiety, and suicidal behavior in patients with obesity on glucagon like peptide-1 receptor agonist therapy
https://www.nature.com/articles/s41598-024-75965-2
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Aerosmit
#305
I started on Triz and switched to Sema after about 8 months. I was quite surprised that Sema made me depressed, where Triz had no such side effect. Needless to say I went back to Triz, now I’m switching to Reta, so far so good.
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adssx
#306
There’s a lot of anecdotal evidence about GLP1 effects on mood but no one knows why…
@Aerosmit: interesting! I should try tirzepatide then. How much weight do you lose on the lowest TZD dose?
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Davin8r
#307
I saw this posted on Reddit today, and I’m still baffled by why it didn’t get any media attention despite being published over 2 months ago. It was the first time I’d heard anything about this study.
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adssx
#308
There was a lot of media articles about the suicide risk purportedly associated with GLP1-RAs. I posted some studies in September: Experience with GLP-1s - #95 by AnUser
In particular, these papers show that there’s a great intraclass variability, while the new paper didn’t find massive differences:
(Victoza & Saxenda = Liraglutide)
The first day I tried oral semaglutide, I had strong suicide ideation. I thought about killing myself the whole morning. So, I stopped semaglutide. I tried again weeks later: nothing! It’s been months I’m on it without any suicidal thought. It’s very weird.
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LukeMV
#309
Well after six weeks of Retatrutide, I can confidently say I will never kill myself
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LukeMV
#310
Six week update on Retatrutide.
I overshot my dose because this is the most appetite suppression I’m feeling and that’s not what I want. Resting heart rate is also in a place I’m not thrilled with. I took 1.5mg twice this week (3mg total), so next week I will back down to 2mg and take the full dose once a week. I’ve done a bit of dosing trial and error, experimenting with different dosing strategies.
Hopefully 2mg once a week is the sweet spot where my appetite is less suppressed and my resting heart rate drops back down a little.
I have Ivabradine on the way that I’ll probably receive in two weeks in case my heart rate still needs to go down a bit.
My weight is about 5lbs lower but no muscle loss since my strength is still the same. Overall I feel good. I do resistance training (bodybuilding style) 4-5x per week and for cardio, I do some HIIT and some 2 mile jogs.
Pics
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Oura ring tracks PWV but I don’t know how accurate the tiny little ring is. I’m skeptical.
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I lost 30 lb on 2.5 mg. Lost a total of 70, most between 2.5 and 10 mg. Stalled for 8 months at high dose 12.5. I have to gain muscle to go down much further, but just had shoulder surgery, so it will be a 4-6 recovery.
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With reta, I get more fat loss and appetite suppression with more conventional dosing strategies, say every 5-8 days. I go by feel. If I microdose EOD, I need to use about twice as much peptide to get a similar effect. I’ve used reta at different times since November 2023, most recently for the past 3 months. Something about the bolus dose seems to be important for me.
With tirzepatide I do better on injections EOD or at least 2x/wk. But everyone is different.
I have not figured out the best strategy for cagrilintide yet. It seems to make me sleepy even at 0.5mg.
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Looking really lean and huge, congratulations!
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If you have never taken steroids, congratulations, you look fantastic.
If you have taken steroids to help achieve that body, meh.
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LukeMV
#316
Initially I tried doing 0.5mg daily for about 5 days in a row but it hit my appetite a little too much then too. Either way, I’m going to try conventional once a week at this point.
Steroids or not there is work behind it. You can inject yourself testosterone and other anabolics stuff if you eat shit and do not train you will look the same
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PBJ
#318
I have been on Tirzepatide for almost a year. I do think it has some mental effects on me sometimes. Nothing that is not manageable, but something that people should be aware of.
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That may be so, but the objective of members of this forum is life extension.
Using anabolic steroids to obtain a good-looking body is cheating and shortens life.
If bodybuilding is your thing, regardless of how you achieve it, even if it shortens your health span and lifespan, then have at it.
Nearly every sporting organization in the world, including the IOC, has banned the use of anabolic steroids.
"The use of anabolic steroids by bodybuilders is associated with a shortened lifespan. Several studies have demonstrated a significant increase in mortality among users of anabolic-androgenic steroids (AAS).
A study by Horwitz et al. (2019) found that mortality was three times higher among AAS users compared to non-users, with a hazard ratio of 3.0 (95% CI 1.3-7.0).[1] This indicates a substantial increase in the risk of death for AAS users.
Thiblin et al. (2015) also reported that individuals who tested positive for AAS had twice the cardiovascular morbidity and mortality rate compared to those who tested negative, with an adjusted hazard ratio of 2.0 (95% CI 1.2-3.3).[2] This study highlights the significant cardiovascular risks associated with AAS use, which contribute to premature mortality."
Health consequences of androgenic anabolic steroid use
https://sci-hub.se/10.1111/joim.12850
Anabolic steroids and cardiovascular risk: A national population-based cohort study
https://sci-hub.se/10.1016/j.drugalcdep.2015.04.013
Increased Premature Mortality of Competitive
Powerlifters Suspected to Have Used Anabolic Agents
https://sci-hub.se/10.1055/s-2000-304
Recreational Bodybuilders: Implications for the World Anti-Doping Agency Passport
“Metabolic Consequences of Anabolic Steroids, Insulin, and Growth Hormone Abuse in Recreational Bodybuilders: Implications for the World Anti-Doping Agency Passport - PMC”
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In these situations, where sometimes there is an effect and sometimes not, I always wonder about hidden interactions or confounding factors. It could be other drugs, supplements and even food, ecercise and lifestyle triggers. That is why I’m a huge believer in daily detailed health journal - I’ve kept one for decades, and I can refer to any day in the past for meds/supps I took, any health events, exercise, and so on. More than once I found non-obvious correlations, which was super useful in crafting health strategies. It’s never too late to start, and soon enough you’ll have a good amount of health history and can go looking for relations and interactions.
3 Likes
PBJ
#321
I think that is great advice. I really should start tracking more variables.
LukeMV
#322
Yes I have used steroids in the past. That is why I am on TRT now.
No, it wasn’t healthy. Neither is being overweight, smoking, binge drinking, and doing recreational drugs.
Being addicted to building muscle was my drug.
What bad habits we used to have can’t be changed. We can only control the present and the future.
14 Likes
I lost 5 lbs in 5 weeks taking Tirzepatide in relatively small doses, 2.5mg/wk. I stopped almost 2 weeks ago, but my appetite is still suppressed.
It’s a matter of semantics, but it doesn’t suppress appetite it suppresses stomach emptying.
This had such a significant effect on me because I use time-restricted feeding. I eat dinner between 5&6 PM; my next meal is ~18 hrs later. This gives plenty of time for the stomach to empty. The problem is that I am hungry when I eat my first meal of the day, so I eat a full meal. There are usually only 5-6 hrs between my first meal and supper. This is not enough time for my stomach to empty, so I have barely touched my evening meal.
The result is basically OMAD. I didn’t get enough calories in the first meal, so the weight drop was faster than expected.
BTW: I have had no side effects fromTirzepatide at these doses.
I was going to try Retrutide next, but I don’t need to.
“Glucagon-like peptide-1 (GLP-1) receptor agonists suppress appetite by delaying gastric emptying. GLP-1 receptor agonists, such as liraglutide and exenatide, have been shown to slow gastric emptying, which contributes to increased satiety and reduced food intake. This mechanism is part of their overall effect on appetite regulation and weight management.
The American College of Cardiology notes that GLP-1 receptor agonists delay gastric emptying, leading to increased satiety and reduced food intake.[1] Additionally, studies have demonstrated that GLP-1 receptor agonists inhibit gastric emptying and food intake in both animal models and humans.[2-4] This delay in gastric emptying is a significant factor in their ability to reduce postprandial glucose levels and promote weight loss.”
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