#264

I meant to post this earlier, regarding ivabradine and afib risk. Sounds like diltiazem might be the better option for HR reduction from a GLP, but I’d like to see some data (even anecdotal) that it actually works.

Question: What is the absolute risk of atrial fibrillation from ivabradine?

Absolute Risk of Atrial Fibrillation from Oral Ivabradine

FDA Drug Label Information

According to the official FDA Drug Label, ivabradine increases the risk of atrial fibrillation. The following data is provided:

Study Ivabradine Group Placebo Group
SHIFT 5.0% per patient-year 3.9% per patient-year

Key Points from FDA Label:

  • Regular cardiac rhythm monitoring is recommended
  • Discontinue ivabradine if atrial fibrillation develops

Additional Research Findings

Meta-analysis Results

A meta-analysis of randomized controlled trials involving over 40,000 patients found:

  • Incidence of atrial fibrillation:
    • Ivabradine group: 5.34%
    • Placebo group: 4.56%
  • Relative Risk Increase (RRI): 24% (95% CI: 1.08-1.42, P = 0.003) (27511965)

Estimated Number Needed to Harm

Another meta-analysis estimated:

  • Number needed to harm: 208 (95% CI: 122 to 667) per year of treatment (24951486)

Risk Factors and Considerations

  • Bradycardia, which occurs more frequently with ivabradine, may increase the risk of QT prolongation
  • This could potentially lead to severe ventricular arrhythmias, including torsade de pointes
  • Patients with risk factors such as use of QTc prolonging drugs may be at higher risk

Conclusion

The absolute risk of atrial fibrillation from oral ivabradine is approximately 5% per patient-year, which is about 1.1% higher than the risk in patients not taking the medication. While this increase is statistically significant, the absolute risk difference is relatively small. Healthcare providers should weigh the potential benefits of ivabradine against this increased risk of atrial fibrillation, particularly in patients with existing risk factors for arrhythmias.
[Answer generated by www.DrOracle.ai]

3 Likes
#265

I definitely have not experienced this from Retatrutide. I swear people on Reddit read someone else’s experience and then convince themselves they have it too.

3 Likes
#266

FWIW, there is apparently evidence that GLP-1 inhibitors cause people to lose muscle mass as well as fat. It is probably a good idea to combine it with resistance training.

See this video:

[Url pasted in directly on its own line. :wink: ]

5 Likes
#267

As of today, there’s no evidence that you lose more muscle with a GLP1-RA compared to the same weight loss with diet or bariatric surgery: Intermittent (oral) Rybelsus / Semaglutide use in healthy individuals? - #420 by adssx

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#268

So yes, absolutely combine w/resistance training and adequate protein intake, which would be true regardless of the method of weight loss.

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#269

image
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https://x.com/bryan_johnson/status/1869779170945126850

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#270

@adssx would you mind copy/pasting a bit more of his post for those of us who don’t have an account on X?

1 Like
#271

It’s 8 long tweets so not super practical. Create an X account, it’s worth it :wink:

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#272

I’ve lost 15 pounds in 2 months with 0.25mg per week of compounded semaglutide. Few side effects. I’ll switch to Tirzepatide as soon as I can get it!

1 Like
#273

Can’t access Twitter, but I’m guessing he wants to lose more weight? Twitter not allowing people that are not logged in to see content is just hostile, BTW.

#274

No he doesn’t want to lose weight and that’s why he’s micro dosing.

1 Like
#275

FWIW: N=1
I am very impressed with Tirzepatide.
I am using it to eliminate a small amount of remaining external and visceral belly fat.
After only 1 week, I noticed a decrease in appetite. After 2 weeks, I had a noticeable decrease in appetite, and when I am hungry, I am satiated quickly. I rarely clean my plate.
My goal is to maintain a BMI of ~22 +/- .5 while increasing muscle mass. At the same time, I am reducing fat. Presently, I have a BMI of ~22, and I weigh myself every few days and adjust my calorie intake up or down depending on my scale reading.
I inject Tirzepatide directly into the belly fat I am trying to get rid of. After only 2 weeks, there is a noticeable reduction.

There have been zero side effects, and I plan on taking Tirzepatide indefinitely.

So, many peptides, so little time.
I chose Tirzepatide based on a bit of research:

“Tirzepatide is a dual agonist that targets both the glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptors. This dual action is unique compared to traditional GLP-1 RAs, which only target the GLP-1 receptor. The GIP receptor activation by tirzepatide enhances insulin secretion and has additional effects on reducing food intake and body weight, although the exact mechanisms in humans are still being studied.[1-3]
Efficacy:
Tirzepatide has shown superior efficacy in glycemic control and weight loss compared to traditional GLP-1 RAs. In the SURPASS clinical trials, tirzepatide reduced HbA1c by 1.24% to 2.58% and body weight by 5.4 to 11.7 kg, which are unprecedented results for a single agent. A significant proportion of patients achieved normoglycemia and substantial weight loss.[1][4-5] Tirzepatide was more effective than semaglutide, a leading GLP-1 RA, in reducing both HbA1c and body weight.[1][5]”

“A thorough review of the studies that led to tirzepatide’s approval allows for comparisons between tirzepatide and GLP-1 RAs; it also allows for predictions of tirzepatide’s eventual place in therapy - an agent used preferentially over GLP-1 RAs in patients with or without diabetes desiring to lose weight.”

4 Likes
#276

Where are you buying your tirzepatide?

#277

Been on the Retatrutide for almost five weeks. I keep modifying the dose but have used about an average of 2.5mg per week. I love this stuff. I wasn’t even trying to burn fat and it still fell off. I bloat less from cheat meals and still wake up lean the next day. Strength is as high as ever. My face even looks thinner. I’m a believer

5 Likes
#278

I got mine from Steve Combi. He was offering a special price for Rapamycin News forum members. I don’t know if he is still offering this. DM steve combi @Steve_Combi
you can also get it from peptide suppliers like:

5 Likes
#279

Rt is my personal go to… I have found it to have fewer side effects and I feel “normal” compared to Tz. Now Tz is also ver effective and over time people do acclimate to it and find their normal with it as well.

After 17 months (8m Tz, 9m Rt) I could not be happier with my weight and the peace of mind that brings.

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#280

Pics from today playing tennis fueled by Retatrutide

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IMG_81891206×2428 434 KB

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#281

Is there a such thing as Ozempic face?

#282

Probably just from weight loss in general.

5 Likes
#283

Quite so. I do feel normal on both 21 months into using these. I think I’ve landed on using reta for cuts and tirz for maintenance, one reason being that I get hyperesthesia on reta so I don’t like being on it for too long. The other is that tirz is cheaper per mg and I need less of it to get appetite suppression. Even on 12 mg of reta it’s hard to maintain a deficit of more than 15% while doing daily cardio and weights, but I know I’m an outlier.

1 Like