#1

Reviews for dante are a bit of a mixed bag but my experience back in December 2019 was good

As an interesting side note I just went through some of their reports and see i am a fast metabolizer of sirolimus and require higher doses

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What kind of DNA analysis (whole-genome bisulfite sequencing for metylation?) for DIY analysis?
#2

That is super coolā€¦a small layer of the onion unravels.

#3

Hereā€™s the report, though whereas Dante says in their reports i am not at risk of Gaucherā€™s disease promethease says I am, so interpret with care

Screenshot_20220805-163512_OneDrive
Screenshot_20220805-163512_OneDrive1768Ɨ2208 185 KB

#4

Did this report change ANYTHING (interventions, other) for you?

#5

I found lotā€™s of interesting stuff about my heritage but except for being homozygous for mthfr a1298c and that I respond badly to many types of chemotherapy my genes luckily are quite boring. (There are a few other things which are good to know, like being a carrier for factor v leiden, which I think is sort of fun because I am from leiden and studied medicine there when the gene was discovered)

#6

Thatā€™s pretty informativeā€¦I am homozygous C677T, impaired methylation, so had to address Homocysteine and choline, so very helpful to know. I am homozygous H63D, so mild iron elevation, led me to start donation, which serendipitously, resulted in blood donations as major bio-hack. I think anyone interested in longevity should have a genetic lookā€¦precision medicine.

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#7

CLIA certified or DTC?

#8

What are those abbreviations?

#9

Clinical Laboratory Improvement Amendments

https://www.cms.gov/Regulations-and-Guidance/Legislation/CLIA

DTC=Direct to Consumer
Basically, can be low validity.

Not only that, the lower costs in DTC tend to correlate with privacy risks. Itā€™s no surprise DTC giants for WGS are heavily VC funded with what seems to be at first glance ultra high valuations.

#10

Dante is an Italian company, so gdpr compliant

#11

Doesnā€™t matter if they get bought out in bankruptcy or get used for exempt purposes. They could also get hacked.

I would just be wary and simply use my second legal name on a different passport

#12

Dante seems to have poor reviews on Trustpilot and other places (long turnaround times and poor communication).

Are there an other direct to consumer options for HiFi Whole Genome Sequencing (long reads)? All I am finding from the competition are 30x or 100x short reads.

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#13

Maybe the reviews arenā€™t real? I and a friend both had good experiencesā€¦