#1374

Does anyone know what the side effect list on Drugs. com is based on? Reports from users?
https://www.drugs.com/sfx/dapagliflozin-side-effects.html

#1375

Could it be that your underlying anxiety has a random or cyclical pattern, and the associations with interventions that you might start or end are, therefore, not causal?

What are you doing to cure your anxiety? (Not an easy thing to do…)

1 Like
#1376

I’m not sure this source is valuable. This gov source does not list anxiety: Dapagliflozin: MedlinePlus Drug Information

#1377

That’s quite possible; I’ve thought the same before. Dapagliflozin reduces anxiety 1-3 hours after taking it, which is why I haven’t stopped it. However, I’ve reviewed my notes more closely to track recent changes, and dapagliflozin is the only thing I haven’t paused for a longer period.

I’ve tried different medications, but they made the insomnia worse. I’m attending therapy and trying various relaxation techniques, and I do light exercise whenever I’ve managed to get at least some sleep.

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#1378

fwiw: For my anxiety and insomnia, the only things that helped were CBT-I and daily meditation (30 min to 1h, initially with the Headspace app then without).

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#1379

Actually, reading another thread, I have come across a report by desertshores who also experienced appetite suppression on rapamycin:

So I am not alone!

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#1380

Mayo Clinic apparently lists anxiety too, not necessarily reliable, but I guess they are based on something, even individual cases?

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#1381

I am one of those people without diabetes or obesity who takes these for prevention. Fingers crossed!

My reasons are that I have heart disease and a lot of neurodegenerative diseases run in my family, in addition to having one copy of APOE4. For me, once I confirmed I have a gene that elevates my risk, the possible risk of intervention decreased.

I’m 58 and take:
6mg of rapamycin 1x/wk
1-1.5mg-ish of tirzepetide or retatrutide 1x/wk
Dapagliflozin daily

I never expected to feel a result of rapa and was only taking it for long term health, but it immediately had an impact on my insomnia. My life has changed as a result. Sleep, as it turns out, is a great thing!!! Who knew? :slight_smile:

FWIW, I started out with rapa almost a year ago, and then months later, as my comfort grew, I added the glp1, and then months later added dapagliflozin.

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#1382

Just an observation regarding my migration from Empagliflozin to Dapagliflozin. It’s been a week since I’ve made the change and my urge to drink a large amount of water in the mornings and early afternoons has largely reduced. Before I was drinking 2–3 litres and now I’m only drinking half. I’m alternating by 1 week each, so will be interesting to see any differences. I’m not sure whether more water is good or bad or what, but I’m still drinking less in the evenings and that is a bonus for getting through the night with less interuptions.

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#1383

I was once concerned about SGLT2i so I did do dapa on/off/on over many weeks without rapa, and did not notice any impact either way.

Since then, I’ve been on dapa so long that I forgot about it, but the rapa experiment was concurrent with dapa, so maybe you’re right. I suppose I could drop dapa and try again.

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#1384

Sodium-Glucose Cotransporter 2 inhibitor Empagliflozin Enhances Autophagy and Reverses Remodeling in Hearts with Large, Old Myocardial Infarctions

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#1385

Nice study, thanks. It is in mice.

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#1386

Thank you for the very reasonable response to my misgivings. What do you think about adding a micro-dose of GLP1. There is a lot of information about anti-aging benefits of this group of medications. Do you think it is reasonable to use the combination of Rapamycin, SGLT2i, and GLP1 for healthy people without ApoE4 or other serious risk factors, genetic red flags?

#1387

Well, we do know that people have used that combination with apparently additive effects, which they deemed positive, such as glucose control and weight loss. I personally remain unpersuaded. I do not find any robust evidence of longevity benefits of GLP-1RA. The extent of GLP-1 health benefits, such as they are, seem to all be the consequence of weight loss and diminished intake of calories. All the multiple benefits that I have seen are a case of “duh” - of course if you don’t overeat, your organs will benefit, duh. But show me a mechanism of benefits that do not rely on eating less and losing excess adipose tissue - because that is definitely the case for SGLT2i drugs.

Therefore adding GLP-1RA is a very individual specific consideration - if you need to lose weight and/or control overeating, and have no better way of accomplishing that, then sure, add GLP-1RA. I personally don’t need to lose weight and I don’t overeat so I am not adding it to my stack.

There is one other consideration, which might persuade me to add GLP-1RA, and that is glucose control. If all my other interventions fail to get my BG down to reasonable levels, and especially if my glucose control deteriorates as a result of rapamycin and nothing else is working, then I’d look to add a GLP-1RA, because I want to prevent metabolic derangement. If that were to happen, I’d start with semaglutide, seems the safest with the longest track record.

Bottom line, I personally, for my situation at this point see no benefit to adding GLP-1RA , but it is not unreasonable for others in a different situation to do so. But those reasons in my mind are centered around the amelioration of metabolic disregulation and not longevity or health benefits in healthy individuals. Those pleiotropic benefits in healthy individuals are persuasive to me for SGLT2i drugs and as for rapamycin it’s a calculated gamble that there will be benefits.

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#1388

I think it’s totally fine as long as you don’t have any type of health related concern where one of these could pose a risk.

#1389

Your personal decision about which medications or supplements to take for prevention of neurodegenerative diseases makes a lot of sense to me, considering your family history and APOE4 gene. You are also trying to optimize your sleep, exercising regularly and following healthy diet, which of course is even more important!

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#1390

I absolutely agree with your reasoning!

#1391

I have been on Tirzepatide(GLP-1) for 6months-no issues. I just tried to add in 10 mg of empagliflozin and it just flattened me. No energy. Is this common? Do you try 1/2 dose? 1/4 dose?

#1392

I had the same experience when I added 100mg canagliflozin to my 1mg weekly retatrutide. I backed cana down to 50mg and it got a bit better. I also tried to eat more carbs and that helped too. After sticking with it for a few weeks, the fatigue was gone. I’ve since ramped my daily cana up to 150mg.

It took some time for my body to adapt, but I feel much healthier now with much more energy that I had before adding in cana.

I should also mention that being on this combination makes me MUCH more sensitive to rapamycin. I used to take 10-20 mg weekly without feeling anything. But now, even 2 mg leaves me feeling starved, energy deprived, and incredibly irritable. I’ve stopped taking it.

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#1393

Did you make the switch in a day with no washout period? Is Dapa known for its moderate effect on uresis? I just started taking canagliflozin and my water consumption and elimination has increased dramatically.