Arhu
#228
Had these mice gained weight since adulthood?
Right ok.
FWIW my body weight dropped from 78 to 72kg off 6mg per week of Rapamune (possibly more bio available than other forms) whilst my strength (relative and absolute) increased.
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I had about a 12 lb weight loss with rapamycin and it’s maintained.
Humans have a genetic set point for their weight which makes it very difficult to budge. We can compensate for even vigorous exercise and our weight will remain stable.
I have triathletes who can’t lose weight and just remain at their set point. Not sure that the same is true in other species.
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MAC
#231
If only Rapamycin as causative, then modicum of signal concordance weight and strength
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MAC
#232
Eat less. That’s not genetic.
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“You’d think at least some people would be reporting significant weight loss? Thus, my grand reservations.”
Since I had already reached my desired weight using time-restricted feeding, diet, and exercise, I can’t report that it induced weight loss, but I think it might because I have had an almost complete loss of appetite since taking rapamycin for several months and I have to force myself to eat enough food to maintain my desired weight.
I wonder if anyone else has had decreased appetite since taking rapamycin.
Actually, loss of appetite is not the correct term. The fact is: that I am rarely hungry.
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David
#234
Great points! Yes, we need human data. I have not looked at CR literature in awhile on longevity, but 20 years ago there was a depression risk noted with it. Is that still a thing?
Agetron
#235
Pic in spring 2020. hadn’t started rapamycin
Pic today Aug. 2022.
Can’t get first pic to the same proportion - it is smaller - but to me the muscle is bigger but lack definition. Loss in size (not strength ) made the bicep more cut. Same workout past 4 years. so why the sudden definition? And, my arm hair grew back thicker since rapamycin.
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MAC
#236
You definitely look leaner…not only your arm but upper chest vs a recent similar regional pic. Whether you are a total whole body lower lean mass vs prior Rapamycin, that would have been interesting parameter. But you look amazing currently at 64. If you’re going to want to follow lean mass over time (new interventions, aging) do a baseline DEXA.
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Agetron
#237
Thanks young guy!
I was at 196 pounds… shooting for 200 pounds once in my life… so close and then rapamycin started to shred any extra adipose tissue - fat!
Stuck at 180 pounds now… and very shredded compared to before… for me it was the rapamycin… only additional thing in the past 2 years.
Definitely getting my DEXA next… live pretty rural so need to find hospital or clinic that does bone, fat, muscle scan… my local hospital has a new scanner but only has software for bones? Cheez!!
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MAC
#238
Trying to keep up with you! And then you added the hair stack too…sucking wind.
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I am quite happy with the weight loss. I have lost 5 lbs in 2 weeks on Rapa. The best part was I ate like crap during this time and still lost weight (It was international cheesecake week at the Cheesecake Factory - went there twice with family). I hope it continues. Thank you rapamycin!
I know, I know. Why did I do this? At least I convinced them not to go three times in a row. Although we did take cheesecake home for the next day. My family is not as health conscious… 
Love those guns, Agetron! Are you going to be the forum representative model?
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“It was international cheesecake week at the Cheesecake Factory - went there twice with family”
Dang! I didn’t know that or I would have been there too. Don’t feel bad.
Auntie Mame says: " Life is a banquet, and most poor suckers are starving to death!"
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Agetron
#241
Hahaha… I guess they will do for a 64 year old fart! If I can hover at this size another decade… won’t complain.
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I am starting to believe that many people here cannot see the benefits of certain interventions (supplements, dietary changes, etc…) because they are too healthy! I am definitely not there (working on it though). However, I seem to see outsized gains when I do adopt a new strategy. I am thinking that this is because I am coming from a place of being not as healthy as the rest of you! However, it does run the risk of us discounting a strategy that may be useful to others even though it may not move our health needle.
Solution: We need more unhealthy guinea pigs… I mean volunteers to try new things!
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Could be some truth to that. Seems like everyone is very health conscious and very likely not representative of the average person.
If you’re bed ridden it’s a huge step up in health just to get in a chair.
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MAC
#244
@DeStrider
There is some merit to what you are saying…it’s all in the control reference point.
One of the big criticisms of mice studies is the “AD LIBITUM (AL)” control mice. This artificial construct results in lower longevity control mice, and thus inflates an intervention. For example, wild type mice NEVER feed ad libitum in the wild…so it’s ridiculous to call them “wild type”. They are only referenced as wild because they are a natural strain, not transgenic. NOT because of their dietary feeding habits.
So you have this wild type mouse eating massive quantities of food, outside it’s evolutionary history, ramping up all manner of aging pathways…they die YOUNG.
So then you overlay an intervention that say lowers food intake or other appetite dysregulation…and voila, the intervention looks amazing…relative to the control.
The basic premise of control fed mice is ERRONEOUS.
Makes you wonder about the biggest lifespan intervention in mice…CR. The intervention is all about restricting calories relative to AL mice?
Thus, this could explain a significant issue with human translation impact. The effect is much larger in mice, and humans have a tightly controlled set point that is much harder to shift to a new homeostasis.
Great! We are all here to listen and learn and improve.
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A good summary of possible longevity interventions (supplements and drugs) and some of the research behind each of them:
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Very informative summary. Also interesting is the review of IP6 + inositol at the very end of the page.
Not only is it cytotoxic to cancer cells but it also lowers A1C levels and at 4 grams of inositol there’s a very sig drop in cholesterol and triglycerides.
Some life extension as well.
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tongMD
#247
I’m not sure set point theory really makes sense to me - or at least there is much more going on. Personally, I’ve fluctuated between ~145-205 lbs give or take (several years), depending on adaptation and food intake if I really pushed my stomach as I did in earlier years. Just never went above 14% body fat, as I suspect there is some cutoff range.
The classic example is the Standard American Diet - it appears to be obesogenic enough to disrupt this theorized homeostatic process. Our genes barely changed over 200 years.
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