Jonas
#591
Thanks, What do you think bought on your psoriasis? Did your psoriasis just go away on its own? I have a lot of sun exposure overall, so it’s doubtful that I am low on D but will test it. My psoriasis is possibly brought on by Dupixent, a bi-weekly injection for eczema.
Methotrexate, for psoriasis and possibly psoriatic arthritis. The mx stopped working and am trying to find a substitute that is less toxic/with less side effects.
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I’ve increased my Vit D to 3,000 IU per day, and will have it retested, thank you…
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Jonas
#594
LDN? Colchicine? All anti-inflammatory with different pathways. Have you tried prednisone? am not sure if and when needed, prednisone is worse than methotrexate. Has rapamycin helped your psoriasis thus far?
I’ve taken LDN on and off for years and don’t see improvements. Same with sups, although that’s a moving target as I find more and better research. Had a bad reaction to prednisone. Would like to try colchicine. Too soon to know if rapa will help, but will post results in a month or so. Thanks for your suggestions 
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Just FYI, colchicine interacts with Rosuvastatin. I saw that in the literature today.
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I am not sure. I think it was simply bad cellular nutrition (not enough Vitamin D, possibly a shortage of Magnesium.) When this happened I was not keeping the same amount of records. It is possible, for example, that melatonin helped. I cannot really say.
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$30K per year, broken down into quarterly payments.
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Thanks. That’s a lot. I suppose you like them well enough to pay it. I am using Healthspan for a light hand-holding experience as I was uncomfortable diving right into buying from a “cousin of a neighbor of a friend who knows a guy with a good track record.” With Healthspan, I get a little bit of advice (although I don’t ask now that I found this site) and a promise to look at my bloodwork for signs of a problem (and a requirement to get blood tests, which I like). But, I only pay 1/10th what you pay. The information I get on this site has been very helpful yet I still feel like I’m wandering around in the dim light.
I get it.
But there’s so much more to this game than just having access to high-quality drugs and supplements. Testing is a huge issue, especially if you don’t even know what tests you should be taking or even know that they exist so you can prevent future issues down the road.
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Can you share what testing and physiological measures you track on a regular or periodic basis?
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idb
#603
New here. 49 year old male. 150 lbs. Here’s my stack…
Daily
Stanfield MicroVitamin (D3 25 mcg, K2 90 mcg, B12 1200 mcg, Zinc 5.5 mg, Magnesium Taurinate 126 mg, Hyaluronic Acid 200 mg, Niacin 50 mg, TMG 1 g)
Omega 3 - 1 tbsp fish oil
Creatine - 5 g
Collagen - 10 g
Glycine - 1 g
NAC - 1 g
Melatonin - 0.3 mg (slow release)
Turmeric - 1 tbsp
Matcha Tea - 1 tbsp
Tongkat Ali - 400 mg
Fadogia Agrestis - 600 mg
Taurine - 2 g
Exercise
Zone 2: 4x week, 30-45 minutes
VO2 max: 2 x week, 4 min on, 4 min off (4 cycles)
Strength: 5 x week, 20-30 minutes
食品
Protein: aim for 100-150 g per day
Berries daily
Try for lots of vegetables
…but I love food & flavor so I don’t sweat what I eat at dinner or out with friends (but I don’t gravitate towards junk food).
Other stuff
Sauna: 90 C (194 F), 15 minutes, 7 days/week (after strength training)
Cold Plunge: 7 C (45 F), 4 minutes, 7 days/week (before morning coffee)
Red Light Therapy: 12 minutes, 4 days/week (cool down after Zone 2 or VO2)
I’m looking to start Rapamycin in a few weeks. I’m thinking 12mg every 2 weeks with a 4 week break after 8 or 10 weeks on (undecided on exact cycle).
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“Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others”
What brand are you using?
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shc
#605
Valacyclovir is interesting. I’d hesitate at this point to incorporate it. But, I do wonder if there are certain times when this can be especially beneficial for short-term prophylaxis (e.g. when already suffering from an infection, during high rapa doses, etc.), if at all it’s actually beneficial for prophylaxis.
It does remind of the kind of strategy that travelers use to prevent malaria when flying to risky countries.
CDC - Malaria - Travelers - Choosing a Drug to Prevent Malaria ; I don’t know if all antivirals should be treated similarly however because they operate via different mechanisms.
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“Jimmy Buffett died after a four-year battle with Merkel cell skin cancer”
Still, another reason to use high SPF factor sunscreen and avoid excessive sun exposure.
“Merkel cell carcinoma most often develops in older people. Long-term sun exposure or a weak immune system may increase your risk of developing Merkel cell carcinoma.”
My own experience is; that Rapamcyin mitigates sun damage after the fact.
Sad, always liked me some Jimmy Buffet. I remember some good times listening to him.
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Jimmy Buffett made wonderful music. I have fond memories of sitting on the frat house deck drinking (cheap) beer and soaking up sunshine and jimmy buffett music.
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RapAdmin
#608
Loved his music. Sad to see him go so young. I guess the downside of “wasting away in Margaritaville”. 
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@shc, I live in Africa and no one here takes malaria meds for prophylaxis. You pay attention and if you get it you treat it quickly and aggressively. But it’s a parasite, and treatable.* Shingles and the herpes viruses are a permanent part of your personal ecosystem and antivirals merely control/suppress them.
I’m taking valacyclovir more-or-less daily with doctor approval but no hard science behind it. I’ve been on immune suppressants for years for a condition (now paused as I try rapa) and had a mild shingles outbreak, despite being vaccinated, during COVID. Between lockdowns, living hours from a city, and not wanting to visit a hospital during a pandemic, my doctor and I decided I’d just keep taking it to avoid a shingles ‘crisis’. He didn’t see a downside, and if I learn of one I’ll reconsider.
*Correction: there is a type of malaria that becomes chronic and acts more like a virus. But most types (protozoa) don’t.
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Blood (serum) to check for inflammation, organ function, metabolic function
Urine to check hormone metabolites and cortisol
Saliva to check hormones and the diurnal cortisol curve, can also track heavy metals, neurotransmitters and micronutrients
Stool to check the microbiome
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