I saw his video from a month ago. Unless I’m mistaken he still takes apigenin, though he gets it straight from parsley and not liposomal supplement like I do. I think he is one of the ones who showed me why someone might inhibit cd38 for nad+. I also wonder if he was using liposomal nmn or just straight nmn? Its risky to use liposomal because there aren’t much studies (or any) on it, and some question the health of liposomal delivery. Apparently just taking straight nmn doesn’t do much good (Stanfield has a good new vid about this)
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I probably have at least fifty different supplements on my shelves. I am usually taking 15-20 of them daily. It is a real battle to keep them down to a reasonable few. One of the things I try to do is ask myself from time to time: Why am I taking this?
Today I decided to review my reasons for taking Berberine and found out that it has some unusual properties that I was not aware of; mainly, its action on the mitochondria.
“The first time, we used molecular docking and dynamic of Berberine with UCP1 gene in this study and revealed therapeutic potential of Berberine via modulation of mitochondrial UCP1 gene.”
It also inhibits lipogenesis. So berberine supplementation is also a contributing factor to my low lipid levels. I was certainly unaware of this property. It also appears to have some anti-cancer properties.
“Berberine (BRB), an alkaloid with anti-hyperglycemic and hypolipidemic properties, was recently shown to inhibit cellular lipogenesis, and respiratory complex I activity, exerting antiproliferative activity against tumor cell lines and tumor xenotransplants7,8,9,10, through mechanisms involving mitochondrial functions”
https://www.tandfonline.com/doi/abs/10.1080/07391102.2021.2024255
https://www.nature.com/articles/s41598-020-73594-z
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A guide to Berberine dosing:
“The optimal dose of BBR was 1 g/day for TG, TC, and weight, 1.8 g/day for insulin and HOMA-IR, and 5 g/day for HDL.”
“It requires a strict dosage regimen. Berberine has a short half-life of several hours — half the dose will be metabolized and eliminated from your system within a few hours. To keep blood levels stable and benefit from berberine, spread the daily dosage (up to 1.5 grams or 1,500 milligrams daily) throughout the day. Dr. Bradley recommends taking it three times a day before meals.”
Berberine for Weight Loss and Insulin Resistance – Cleveland Clinic)%20throughout%20the%20day.
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Thanks. I have also heard it was an effective antimicrobial for shifting gut flora towards a healthy composition. I have started to skip my berberine dose when I take metformin (I’ll still take the breakfast berberine but skip the dinner dose if I’m taking metformin after dinner). I felt that my blood sugar was getting too low.
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Hi, Apologies for the delay in getting back to @Leonard but it was a long weekend here in the UK.
My regime looks like this: 8 weeks MK-2866 at 12.5 mg per day followed by 4 weeks post-cycle therapy of Tamoxifen and then 4 weeks of pure down time.
Hope that helps. 
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scta123
#576
Why did you choose tamoxifen and not clomifene or enclomifene? Are there and benefits in using tamoxifen?
What are your results with MK 2866?
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scta123
#578
Thx. I will check your references later, but good to know. So you take tamoxifen for a month every four months if I understood your protocol correctly.
Does taking tamoxifen give you any unwanted side effects?
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MK 2866, even at much lower doses (2mg per day) eliminates muscle wasting and increases (I’ve certainly noticed) muscle mass. Its also good for collagen and noticeably decreases my skin age. Its also the mildest, that’s why I use it.
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Yes, I think it decreases my white blood cell count and results in some bruising, This could be because my white blood cell count was already low as a result of Mavenclad. The symptom has not been severe enough to discontinue during 4 weeks and I return to normal quickly after discontinuing. But yes, there are risks and I would never advise anyone on following my example. I’m not medically qualified.
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To all those who directly messaged me about where to obtain Rapamycin, Metformin, NMN, peptides, TRT, and other pharmaceutical-grade supplements- Maybe one answer will suffice for everyone at the same time.
I don’t go through India, China, or anywhere else with possible customs seizures and without strict purity testing. It’s more expensive but… Elevate Your Health and Longevity with Bauman Performance
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What is their program? A membership, buy meds from them (with profit built in), or what? I use Healthspan which sells med on a subscription at a price that covers doctor and operating costs and a profit. They offer a variety of meds including rapa.
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It’s an all-inclusive program, with no upcharges for anything, basically, whatever you need based on a full battery of testing for everything from cancer to metabolic syndrome, etc. Whatever it takes to optimize your health.
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What brand of rapamycin are you using? Do you get a brand such as Pfizer or is it from a compounding pharmacy?
Can I ask how much they charge for the all inclusive program?
Jonas
#586
does that mean you are not on metformin then? how long have you been on Berberine, how it has improved your bio marker?
Jonas
#587
what kind of immune suppressants and why? psoriasis?
约瑟夫
#588
For those who are not familiar;
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Right now, I am taking 500mg of metformin with my rapamycin. I don’t take metformin on days I don’t take rapamycin.
As for berberine, I originally started taking it for glucose control. It had very little effect that I could detect. It has many properties and may have contributed to my low lipid levels.
I am taking a shotgun approach with the many supplements discussed and recommended here,
so it is impossible with so many variables for me to tell which ones are having the most effect.
My age reduction from taking this approach using the Levine-derived spreadsheet and Aging.ai
age calculators is ~15 years.
My main supplement list is fairly stable right now so if I add or subtract a new one I might be able to tell the effect.
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psoriasis
I had some psoriasis about 4 years ago. I would suggest blood test for 25OHD, If this is low take enough D3 to bring it into midrange.
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