#182

What I like about the large dose cycling with testing is that you see the various biomarkers move around. Hence glucose initially goes up and then comes down and similarly WBC go down and back up.

At the moment I am planning another 22+GFJ on 8th December. I see no reason not to do this.

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#183

Am I missing something, or does Bryan’s [5] study that he references actually say the opposite of what he’s claiming? I understand this study as saying that rapa consistently decreases epigenetic age across multiple DNAm biomarkers . https://www.biorxiv.org/content/10.1101/2024.10.22.619522v1.full.pdf

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#184

Let us know what happens when you have the data.

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#185

Ok here is a massive study narrowing the range down further and concluding that 120-160mg IGF1 to be the optimal range for lifespan.

“In conclusion, by analyzing and comparing different ranges of IGF‐1 in 30,876 subjects, we find that both high and low levels of IGF‐1 increase mortality risk, and for the first time, we identify a specific mid‐range being associated with the lowest mortality (120–160 ng/ml). Using the NHANES III survey, we show an association between high intake of animal proteins, carbohydrates, and milk‐based products and IGF‐1 levels. These results can point to diagnostic, nutritional, and pharmacological strategies to optimize IGF‐1 levels and help reduce mortality.“

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#186

This is why I love this community

#187

Sorry to disappoint you LOL but thought we were talking about current number which is 8+ close enough to 10

#188

By citing largely irrelevant studies in his justification, Johnson harms his reputation. By not being open about possible side effects over the last five years of rapamycin, he has broken his promise of openness. By ignoring the huge amount of science in favor of rapamycin, he is not making an honest argument. We deserve science based arguments, not vague hand-waving.

If I had been in his position, I would have taken a break from rapamycin for several months, watched the results, and then tried 1mg-2mg weekly, increasing as tolerated.

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#189

The more I look at him, the more I do not want to be like him…

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#190

Is that better than doing a higher does for 30-90 days and then cycling off for the rest of the year?

#191

It depends on how rapamycin works. I think its positives come from mitophagy. Hence having a high level of mTOR inhibition for a short time is good. I think its negatives come from inhibiting cell division. Something to avoid most of the time.

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#192

Thanks @LukeMV The first word of the title of that paper is literally “Association”

We know that disease states can lower IGF-1, so much of the causation there would be going from disease => low IGF and not low IGF => disease

Umbrellas :open_umbrella: make it rain :cloud_with_rain: type of dynamic would have to be removed and that dynamic is likely not small and may even be the entire effect…

It’s like cancer => low HbA1c so then people argue that higher HbA1c is better than lower

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#193

It’s a good question and I don’t know the honest answer. However, there are a number of studies showing HGH therapy in a deficient state (which increases IGF1) has profound benefits. Personally, I’d be very uncomfortable with a very low IGF1.

There was a similar discussion here Greg Fahy: We may have discussed what this guy is doing but can we talk more about him - #81 by LVareilles

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#194

I decided to stop as well. Made it almost a year but the side effects for me just made it unbearable.

No matter the dose or frequency, ie every 2 weeks, every week, 6mg, 3mg….i got flu like symptoms a couple of days after taking. Also, rapid heartbeat, mouth sores, skin boils.

I’m done

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#195

I can totally believe that. Not trying to argue against that there can be sick/disease/deficiency states.

But what type of deficiencies are we talking about, generally severe? I perhaps misunderstood that you were talking about IGF-1 up being something similar comparable or ballpark of the effect of mTOR down via rapamycin for generally healthy individuals too, but perhaps that is not what you meant?

#196

If he’s taking it weekly or biweekly, it would be pretty obvious changes in various parameters timed with rapamycin dosing. Rapamycin easily has a larger effect than probably 50 of those supplements combined too.

For what it’s worth I still think that rapamycin is the best longevity drug, and it’s no coincidence that drugs like acarbose in combination with it are the best thing we have right now (since rapamycin affects glucose control and lipids). Finding out how to control the negatives to rapamycin is probably key.

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#197

I just requested the IGF-1 blood test… hopefully will get the results for this weekend. All the other blood test for Neutophil and Granulocyte …etc… my GP says I need to see a HIV specialist to be able to get them for free LOL. So I guess I wont be doing them.

IGF-1 results

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Interesting… all within normal ranges.

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#198

That’s a lot assumptions you are making.

  1. You are assuming none of the supplements potentiate via metabolism, synergy, etc. the action of rapamycin.

Rapamycin easily has a larger effect than probably 50 of those supplements combined too.

That’s a wild guess, he’s taking over 100 BTW. I would agree that rapamycin has a larger effect than 50 of those supplements in a head to head comparison. BUT once you mix up 50 or so, you literally have no clue how they interact with each other. It’s just as likely than a 20 of them together have a larger effect than rapamycin. We can sit here and make wild guesses all day, because nothing about this is scientific.

IF BJ REALLY wanted to figure out the effects of rapamycin on his body, he would discontinue all of his supplements and treatments (blood transfusions etc.) Undergo a wash out period of say 6-12 months. Then reintroduce the rapamycin and observe/measure the effects of rapamycin over a period of at least several months without any other confounding variables… you know like the way science is actually done.

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#199

If you don’t mind sharing your age, sex and state of health that would be useful to know in respect to rapamycin use.

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#200

I’m Male, 64 I’m reasonably good health.

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#201

Ive got data going back 5 years 1 year before and 4 after starting rapamycin
My NLR has been consistently in the 0.7-0.8 range
I see no effect of rapa
6 weeks away from 72, male in good to great health

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