#188

By citing largely irrelevant studies in his justification, Johnson harms his reputation. By not being open about possible side effects over the last five years of rapamycin, he has broken his promise of openness. By ignoring the huge amount of science in favor of rapamycin, he is not making an honest argument. We deserve science based arguments, not vague hand-waving.

If I had been in his position, I would have taken a break from rapamycin for several months, watched the results, and then tried 1mg-2mg weekly, increasing as tolerated.

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#189

The more I look at him, the more I do not want to be like him…

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#190

Is that better than doing a higher does for 30-90 days and then cycling off for the rest of the year?

#191

It depends on how rapamycin works. I think its positives come from mitophagy. Hence having a high level of mTOR inhibition for a short time is good. I think its negatives come from inhibiting cell division. Something to avoid most of the time.

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#192

Thanks @LukeMV The first word of the title of that paper is literally “Association”

We know that disease states can lower IGF-1, so much of the causation there would be going from disease => low IGF and not low IGF => disease

Umbrellas :open_umbrella: make it rain :cloud_with_rain: type of dynamic would have to be removed and that dynamic is likely not small and may even be the entire effect…

It’s like cancer => low HbA1c so then people argue that higher HbA1c is better than lower

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#193

It’s a good question and I don’t know the honest answer. However, there are a number of studies showing HGH therapy in a deficient state (which increases IGF1) has profound benefits. Personally, I’d be very uncomfortable with a very low IGF1.

There was a similar discussion here Greg Fahy: We may have discussed what this guy is doing but can we talk more about him - #81 by LVareilles

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#194

I decided to stop as well. Made it almost a year but the side effects for me just made it unbearable.

No matter the dose or frequency, ie every 2 weeks, every week, 6mg, 3mg….i got flu like symptoms a couple of days after taking. Also, rapid heartbeat, mouth sores, skin boils.

I’m done

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#195

I can totally believe that. Not trying to argue against that there can be sick/disease/deficiency states.

But what type of deficiencies are we talking about, generally severe? I perhaps misunderstood that you were talking about IGF-1 up being something similar comparable or ballpark of the effect of mTOR down via rapamycin for generally healthy individuals too, but perhaps that is not what you meant?

#196

If he’s taking it weekly or biweekly, it would be pretty obvious changes in various parameters timed with rapamycin dosing. Rapamycin easily has a larger effect than probably 50 of those supplements combined too.

For what it’s worth I still think that rapamycin is the best longevity drug, and it’s no coincidence that drugs like acarbose in combination with it are the best thing we have right now (since rapamycin affects glucose control and lipids). Finding out how to control the negatives to rapamycin is probably key.

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#197

I just requested the IGF-1 blood test… hopefully will get the results for this weekend. All the other blood test for Neutophil and Granulocyte …etc… my GP says I need to see a HIV specialist to be able to get them for free LOL. So I guess I wont be doing them.

IGF-1 results

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Interesting… all within normal ranges.

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#198

That’s a lot assumptions you are making.

  1. You are assuming none of the supplements potentiate via metabolism, synergy, etc. the action of rapamycin.

Rapamycin easily has a larger effect than probably 50 of those supplements combined too.

That’s a wild guess, he’s taking over 100 BTW. I would agree that rapamycin has a larger effect than 50 of those supplements in a head to head comparison. BUT once you mix up 50 or so, you literally have no clue how they interact with each other. It’s just as likely than a 20 of them together have a larger effect than rapamycin. We can sit here and make wild guesses all day, because nothing about this is scientific.

IF BJ REALLY wanted to figure out the effects of rapamycin on his body, he would discontinue all of his supplements and treatments (blood transfusions etc.) Undergo a wash out period of say 6-12 months. Then reintroduce the rapamycin and observe/measure the effects of rapamycin over a period of at least several months without any other confounding variables… you know like the way science is actually done.

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#199

If you don’t mind sharing your age, sex and state of health that would be useful to know in respect to rapamycin use.

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#200

I’m Male, 64 I’m reasonably good health.

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#201

Ive got data going back 5 years 1 year before and 4 after starting rapamycin
My NLR has been consistently in the 0.7-0.8 range
I see no effect of rapa
6 weeks away from 72, male in good to great health

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#202

Oh no I was just noticing that both HGH and Rapamycin improve lymphocytes, T cells, and other things of this nature. I am wondering if the mechanism is similar but I don’t think it is related to mTOR, since HGH would not suppress mTOR.

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#203

I’d not expect a big difference given you’re about as optimal as possible. I’d say if you started out at 5 or 8, that’s were I’d see some difference (or even 2)

@LukeMV I think HGH due to regrow of the thymus with this has this effect, so it’s a bit different etiology - but this should re-invigorate T cells.

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#204

That’s a very good hypothesis. Probably is correct.

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#205

Yes I’m making many assumptions, you have to in this situation. There’s no reality where bryan is going to drop everything just to test rapamycin so the reality is he will just be testing it in his context. I however have had times where I only take rapamycin and I share the same side effects, and they are found replicated elsewhere so it’s hard to believe he is wrong on these.

I do hope there are obvious wins out there through just taking a supplement, however I have a strong assumption that most supplements end up having really minor (if any, or negative even) effects, excluding the ones already validated some amount through the ITP. I’m not sold on his blueprint stack of supplements, there are only a few things in it I’m really interested in

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#206

Just curious…how much rap do you take? And how much do you weigh?
Thanks

#207

I’ve noticed slight improvements with my autoimmune issues, if that’s worth anything. Make sure to monitor your lipids/Glucose regardless… but I’ve had no such issues. I actually have had skin issues, including pimples/boils but it does calm down a bit after a while. BJ also complained about this… and he has become very vain, so I wonder if this was at least partially responsible for his decision.