#42

I finally got my latest CRP (0.24) which puts my Levine phenoage at 49 (vs 61 chron and 26 aging.ai). My aging.ai has slowly crept lower every test while Levine has bounced up 2.6 years and back down 1.8 years in last 5 mos. Since starting rapa.

Aging.ai: 28–>27–>26
Levine: 48.2–>50.8–>49.0

Big movers (pre-rapa, +2mos.,+5 mos)

Albumin: 4.9–>4.4 —> 4.9
CRP: 0.28–>0.19–>0.24
Lymp: 48%—>42–>40
HbA1c: 5.8–>5.6–>5.5 (started metformin)
LDL: 71–>44–>35

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#43

This is statin? PCSK9i? Or just rapamycin? :sweat_smile:

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#44

And ApoB decreased from 64 to 48.

I’ve been on rosuvastatin 5mg and ezetimibe 10mg for a year. I added vit b5 and niacin 2 mos ago. I also started eating 3-4 eggs per day and stopped eating nonfat Greek yogurt everyday a month ago.

Edit: I also added steel cut oatmeal for breakfast. That could be impacting LDL.

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#45

Cystatin - C came back at 0.75 mg/l. That’s near the low end of the acceptable range but near the high (bad) end of the optimal range (according to selfdecode). But it doesn’t look like I have a kidney problem in any case. Not yet.

#46

Most articles with a paywall are available here: https://sci-hub.se/

Just put either the DOI, PMID, article link etc… and it will open it for you.

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#47

Are you sure this is mg/dl and not mg/l?

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#48

You are right. I edited my post to correct.

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#49

AIUI 0.75mg/l is a reasonable value for a young person (around in their 30s) and does not indicate kidney difficulties.

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#50

High bilirubin can be due to Gilbert’s syndrome, a mostly innocuous mutation which reduces bilirubin turnover. I’ve kind of assumed that’s the case for myself, as I’ve had high bilirubin for the past few years now (latest test 1.7mg/dL).

Any longevity benefits of high bilirubin may be due to its antioxidant activity, which has been demonstrated in-vitro and in-vivo.

Hyperbilirubinemia, Augmentation of Endothelial Function, and Decrease in Oxidative Stress in Gilbert Syndrome
Serum concentrations of malondialdehyde-modified low-density lipoprotein and urinary excretion of 8-hydroxy-2′-deoxyguanosine (8-OHdG), as indices of oxidative stress, were lower in patients with Gilbert syndrome than in control subjects (61.8±24.5 versus 72.5±21.8 U/L, P =0.034; 7.8±2.4 versus 10.4±3.2 ng/mg creatinine, P =0.001, respectively). Flow-mediated vasodilation was greater in patients with Gilbert syndrome than in normal control subjects (7.2±2.2% versus 5.9±1.7%; P <0.001). Vascular responses to nitroglycerine were not significantly different between the 2 groups. Flow-mediated vasodilation correlated with serum concentration of bilirubin (r =0.44, P <0.001), malondialdehyde-modified low-density lipoprotein (r =−0.25, P =0.01), and urinary excretion of 8-OHdG (r =−0.27, P =0.004) in patients with Gilbert syndrome but not in control subjects. In addition, serum concentration of bilirubin correlated with malondialdehyde-modified low-density lipoprotein (r =−0.20, P =0.04) and 8-OHdG (r =−0.21, P =0.02) in patients with Gilbert syndrome but not in control subjects.

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#51

How are you taking alpha cyclodextrin? Powder, capsules? How many mg?

#52

The only time I paid attention to bilirubin was when I was recovering from Hep A in my 20s. I remember taking an alleged pharma product called “Essentiale” by Natterman (Germany), which had phospolipids (choline). [It was/is a high-priced soy product.]. The objective was to reduce bilirubin. I do not remember the numbers. I just took the capsules for three months, and did not have the bilirubin retested.

My recollection is confirmed by this product insert.

The below Mayo Clinic article about bilirubin and liver problems also confirms my recollection about bilirubin and hep A.

Bilirubin test - Mayo Clinic(bil-ih-ROO,liver%20or%20bile%20duct%20problems.

So low bilirubin may indicate cardiac problems. But high bilirubin indicates liver problems. I wouldn’t tinker with it. Staying in the normal range is benefit enough.

#53

I bought powder without knowing. I found 1/4 tsp is about 3 gm, so take it with meals usually twice a day when I think of it. I assume you’ve read this:

https://sci-hub.se/https://doi.org/10.1016/j.pharmthera.2020.107620

It seems to be an expensive way to go. I tried to buy from India and Jagdish informed me that he is a legitimate business and does not handle illegal drugs. I said that’s good to know and I’m not a lawyer and don’t understand the law, but cyclodextrins are GRAS in the USA. They must not be in India. They’re made from starch (corn) which you can buy for nearly nothing, so it must be hard to do.

I use RemChol as well also called Cavidex. I believe this is the polymerized beta form and it works best, in fact it appears to be some sort of miracle. I could not find a way to buy the IV’s and administration is beyond awkward and the yield has to be pretty bad. So also expensive and might not work so well. Although (as I pride myself on not being a total wuss) my skill has improved with practice and my yield is probably as good as it’s going to get now. I will get my annual CAC in Feb. and we’ll see whether I’ve been torturing myself for nothing.

The only down side I have seen is that apparently your ear hairs (cilia) need a drop of cholesterol to work right and at extreme doses cyclodextrins can suck it out resulting in permanent deafness. The guy that invented RemChol took 80 grams IV/day and nothing happened to him. They say half life is maybe half an hour and in my vessels it probably doesn’t last that long as my dose is small and my cholesterol is large. You’ve probably seen their video here:

In conclusion, It’s an amazing drug which Cyclarity will probably get rich on in just a few years. They will probably come out with a drug form of it which is safe and very effective. It can make up for years of bad management. We probably don’t deserve it, but it’s coming. I hope it’s not a &#@* enema.

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#54

I just found this and ordered:

Cheapest I have seen. Most places it is $1/gm, which at 6gm/day is a terrible price. This is more like 9 cents/gram. Almost tolerable, but they listed the active ingredient as water. I hope it’s a language problem.

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Cyclodextrins, Cavadex and Cyclarity for Reversing Atherosclerosis
#55

Let us know how goes for you… I’m assuming you’re using this to lower lipid levels.

#56

Unfortunately it’s out of stock :smiling_face_with_tear: Correction: it’s available if checked at eBay (without following a provided link).

#57

Yes, my yearly full physical will have blood drawn around the solstice (dec 21) which happens to be my birthday.

The alpha form helps with lipids among other things. The beta form actually does nothing to lipids, it takes the plaque out without affecting lipids. My goal has been to take my CAC to zero, which is probably impossible and maybe a crazy meaningless goal. But this chemical which they sell cheap in Japan as fiber, really has me intrigued. Illegal in India, expensive in US. I’ll let you know.

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#58

I think I took her last one, but there must be more. Aren’t markets strange. You would think prices would even out with internet. Nope.

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#59

I bought it! Hope there’s instruction in English. I asked seller about it (hoping they may translate some).

#60

Received mine with translation:

[Raw materials] α-cyclodextrin * α-cyclodextrin content is 98% or more [Nutrient ingredient indication] Nutritional ingredient (per 100g of product) Calorific value 187kcal Protein 0.1g Fat 0.1g Carbohydrate 90.4g Sodium 2.1mg Ash content 0.1g Water 9.6g Dietary fiber 87.4g ※ α-cyclodextrin content is more than 98%

Raw materials are made from corn starch and are 100% natural.

NICHIGA [Nichiga] α-Cyclodextrin ※, α-Cyclodextrin content is as high as 98% or more.

Ingredients: Made from corn starch, 100% natural.

Cyclodextrin is a type of indigestible dextrin called cyclodextrin, CD, cyclic oligosaccharides and so on.
The molecular structure is shaped like a bucket, and it is shaped like a small capsule with the inside being lipophilic (to be compatible with oil) and the outside being being hydrophilic (to be compatible with water).
Because of its structure, it has three properties: indigestible dextrin (dietary fiber), oligosaccharides, and adsorbents.

Allergy information None ※ This product factory manufactures products including soybean, wheat, milk and banana.
How to take:
Please enjoy 5g ~ 10g daily as a guide. (Intake of 2-3g is recommended about 30 minutes before the meal)
・ Tasteless ・ odorless and easy to melt, not disturbing the taste.
Please enjoy it in coffee, tea, green juice and smoothie drinks.
・ We mix in rice and cook rice, dish

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#61

Yes, mine came today too. I didn’t get the translation so that helps, thanks.

So much cheaper than the CHemCenter stuff I bought first just to see what it was like.

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