Wow, you and @LaraPo are leading in the reverse biological aging race! Well done!
7 Likes
Bicep
#22
The best reference that I have found is Lustgarten’s book on Microbial Burden. He starts off by talking about the number of microbes in a typical bloodstream, and the number of white blood cells. We are at war with them. We make antimicrobial peptides that latch on like barnicles on a ship. They punch holes and eventually kill bacteria. The pieces of that bacteria are called LPS or lipopolysaccharide. You want this to be as small as possible. 20 years before you die your WBC count increases at a steeper slope.
The IALP (I for intestinal) keeps the bad guys from getting from the gut into the bloodstream. He also talks about oral hygiene and how that that bacteria is what starts heart disease. The third way to be invaded it through the skin.
When IALP fails then serum ALP has to go up to get rid of the LPS. A high ALP means you are leaking and you have high LPS. It is not as simple as this and the relationship is not perfect or linear I’m sure. But yes, you want ALP to be small.
Long day today and harvest is over now, but we’re picking up all the pieces we left for the harvest push. Life will be returning to normal soon.
His book on Kindle is only about $5 and a fascinating read.
5 Likes
@约瑟夫_拉维尔 What’s your current Rapamycin dosing schedule?
1 Like
LaraPo
#24
Is IALP available as a supplement?
scta123
#25
We are tied in this, mine is showing 28 years younger result than my chronological age. 
20 vs. 48.
btw my total bilrubin went up on rapamycin, from 7 mcmol/L to 12 mcmol/L in 6 months on rapamycin.
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@DeStrider I am on a weekly dosing schedule, with 1 week off in 4 (3 on/3 off). I take 4mg w/ GFJ on an empty stomach.
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Bicep
#27
Various people on here have linked to such a thing and Lustgarten talks about it being possible and good in his book. At the time of writing they had nothing, so he says vitamin K1 at 1500mcg and as much butyrate (scfa) as you can make. So soluable fiber (I use psyllium), acarbose (not with wheat), organic acids (like a tart apple) etc… you can read about how to increase scfa’s. The latest and greatest is alpha cyclodextrin, which can really help with heart disease and is oral. It makes it to the colon where it is turned into scfa.
It looks like you are doing way better than I am in this regard. However my WBC count is going down by quite a bit instead of up. So I wonder whether the ALP is such a great marker for microbial burden. It must not be. Rhonda Patrick mentioned a ratio in a recent video I saw on here that works and I didn’t write it down. She was asked directly whether LPS can be measured by your doctor and answered with the best way. I need to find that again.
2 Likes
According to levine low WBC is good. Mine floats around 3 so i am happy with that.
3 Likes
Tomnook
#29
Aging.ai suggests I am 29 y/o 
rather than my chronological age of 69. Levine seems far more plausible at 58 y/o.
Albumin level seems particularly important with aging.ai - my current level is 47 which is way higher since starting rapa (historically 41-43),
5 Likes
Congratulations! You have the ALT of an 82 yr old!
Yours:
Mine:
Sadly, you need to work on your AST
Yours:
Mine:
Keep taking your rapamycin, you will catch up.
1 Like
My ALT is up from 17 to 25 since I started on Rapa. It’s something to watch.
My AST is up from 21 to 28 since I started on Rapa. Hmm.
So liver function and maybe kidney function needs to be watched. I’m waiting for results on a cystatin c test since my creatinine might be wacky due to high muscle mass.
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Maybe something to watch long term, but I wouldn’t be worried about your results.
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Of course, all of my blood markers vary from reading to reading because of the large number of variables taking place in my supplements, diet, and exercise routine.
Here are my markers from the beginning of taking rapamycin to the present:
I really don’t see any changes that I could attribute to rapamycin.
3 Likes
Thanks. The variability makes me think I should get more frequent tests so I can see trends.
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LaraPo
#35
My most recent ALT is 13, and AST 23. Both numbers jump up sometimes for the reason I don’t understand. The previous ALT was 20 and AST 33.
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Bicep
#36
I found the Rhonda Patrick video on LPS and butyrate. She talks about ways to make SCFA about 30 minutes in and the Lactulose/Mannitol ratio as being the way to test for LPS about 40 minutes in. This is a great video and I have reasons for not really liking Rhonda, but this one she really got right:
2 Likes
cl-user
#37
Before everybody get too much excited with bilirubin as new biomarker for the CAC score let’s note that the correlation is mediocre at best (-0.361) even though it is statistically significant (p=0.0001).
That’s clearly useless from a practical point of view, In fact the worst CAC score is seen in people in the 0.75 to 10 range, not the low level ones.
3 Likes
One advantage of frequent tests is to see the variation that occurs without necessarily anything changing.
These are ALP, AST and ALT for the last few weeks
ALP AST ALT
| 62 |
|
23 |
|
|
|
| 54 |
28.1 |
17.4 |
|
|
|
| 50 |
29 |
17 |
|
|
|
| 51 |
23.7 |
17 |
|
|
|
| 66 |
|
18 |
|
|
|
| 52 |
22.9 |
14.6 |
|
|
|
| 56 |
24 |
17 |
One of the labs does not do AST and tends to get a higher value for ALP.
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I just heard that AST and ALT are secreted by muscles as well as liver so these markers are not always reliable indicators of liver function.
I assume this sort of data movement is why family docs just look for “in range” and when out of range they say let’s see what happens next time. They tend to “measure twice and cut once”. I’m starting to appreciate that sensibility more as I get older.
2 Likes
