I would think it is the TO… figure (which I assume is total) That converts to 18.1 micromoles per litre. That is quite high.
I don’t know what that means.
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0.4 mg/dL is 6.84 microMoles per litre. (mcm/L) which is to the lower end.
As a matter of interest here are my most recent values in mcm/L
5.7 6.3 7 10 10.47 7 6.14 7.6 5.99 6.4
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ALP is used in the Levine formula on the basis that lower is better for mortality. When people have damaged livers ALP is higher which is where I think this comes from. My recent values are:
64 61 59 59 62 54 50 51 66 52 56
The lowest I have had was 49 and the highest 136.22 (which was a temporary high). I started out last year averaging around 75 and am now averaging around 60ish.
This is in IU/L which is the same in the USA and the rest of the world (apart from a few places that use something like kat and I don’t know what that is.)
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Neo
#14
Thanks John. I’m at a value of 58, but have never tried to impact it. Are there any strategies you have or think one can use to lower it?
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I don’t have a reference to the expected values of ALP by age. I don’t know your age. Hence I cannot say whether your figure is one worth reducing. Morgan Levine’s formula is driven by links to mortality, but there would be a point at which reducing ALP is potentially a sign of some form of damage.
My initial thought is that anything in the 50s is quite a good value and therefore not something to look at changing.
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Neo
#16
Btw - there is a separate active thread on ALP and how supplementation for the gut might be good for aging:
I haven’t read up on this, but thought I just call it out
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With my latest results (from yesterday), Aging.ai says I’m 26yo biological (vs. 61yo chron). That’s a 2 year improvement since I started rapa (and other interventions). I’ll do Levine next…I need to get a hsCRP that show results below 0.3 (my last test result was 0.19).
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@John_Hemming I don’t know either. Aging.ai shows a range of 0.0-1.2 mg/dl…my result of 1.1 is near the top. In total my Aging.ai result is a very good 26 yo (35 years below my chron age of 61)…i don’t know if the bilirubin is helping or hurting the score. I also don’t feel 26 yo so there’s that.
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Vlasko
#19
The problem with using ALP as a marker is that it is not specific. It is a combined value of ALP sourced from different areas of the body. And using it in this formula is therefore dubious. It is only relevant in basic blood work to the extent that if the total value falls outside the reference range, additional testing is needed to determine the source of the deviation, whether it’s bone, intestinal, liver. So if someone really wanted to track this over time as a marker, what they’d really want is a more comprehensive test with a breakdown. The test is “Alkaline Phosphatase Isoenzymes.”
This is an example report from Quest Diagnostics.
Marek Diagnostics offers the test through Labcorp for $25.
And for the intestinal value in particular, this actually falls with age. And you want to see this value remain higher. Supplemental ALP has been shown to extend lifespan in mice. As previously noted, there is a separate thread on that here.
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LaraPo
#20
My previous age prediction per Aging.ai was 53. Now it’s 40. It’s a big improvement.
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Wow, you and @LaraPo are leading in the reverse biological aging race! Well done!
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Bicep
#22
The best reference that I have found is Lustgarten’s book on Microbial Burden. He starts off by talking about the number of microbes in a typical bloodstream, and the number of white blood cells. We are at war with them. We make antimicrobial peptides that latch on like barnicles on a ship. They punch holes and eventually kill bacteria. The pieces of that bacteria are called LPS or lipopolysaccharide. You want this to be as small as possible. 20 years before you die your WBC count increases at a steeper slope.
The IALP (I for intestinal) keeps the bad guys from getting from the gut into the bloodstream. He also talks about oral hygiene and how that that bacteria is what starts heart disease. The third way to be invaded it through the skin.
When IALP fails then serum ALP has to go up to get rid of the LPS. A high ALP means you are leaking and you have high LPS. It is not as simple as this and the relationship is not perfect or linear I’m sure. But yes, you want ALP to be small.
Long day today and harvest is over now, but we’re picking up all the pieces we left for the harvest push. Life will be returning to normal soon.
His book on Kindle is only about $5 and a fascinating read.
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@约瑟夫_拉维尔 What’s your current Rapamycin dosing schedule?
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LaraPo
#24
Is IALP available as a supplement?
scta123
#25
We are tied in this, mine is showing 28 years younger result than my chronological age. 
20 vs. 48.
btw my total bilrubin went up on rapamycin, from 7 mcmol/L to 12 mcmol/L in 6 months on rapamycin.
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@DeStrider I am on a weekly dosing schedule, with 1 week off in 4 (3 on/3 off). I take 4mg w/ GFJ on an empty stomach.
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Bicep
#27
Various people on here have linked to such a thing and Lustgarten talks about it being possible and good in his book. At the time of writing they had nothing, so he says vitamin K1 at 1500mcg and as much butyrate (scfa) as you can make. So soluable fiber (I use psyllium), acarbose (not with wheat), organic acids (like a tart apple) etc… you can read about how to increase scfa’s. The latest and greatest is alpha cyclodextrin, which can really help with heart disease and is oral. It makes it to the colon where it is turned into scfa.
It looks like you are doing way better than I am in this regard. However my WBC count is going down by quite a bit instead of up. So I wonder whether the ALP is such a great marker for microbial burden. It must not be. Rhonda Patrick mentioned a ratio in a recent video I saw on here that works and I didn’t write it down. She was asked directly whether LPS can be measured by your doctor and answered with the best way. I need to find that again.
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According to levine low WBC is good. Mine floats around 3 so i am happy with that.
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Tomnook
#29
Aging.ai suggests I am 29 y/o 
rather than my chronological age of 69. Levine seems far more plausible at 58 y/o.
Albumin level seems particularly important with aging.ai - my current level is 47 which is way higher since starting rapa (historically 41-43),
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Congratulations! You have the ALT of an 82 yr old!
Yours:
Mine:
Sadly, you need to work on your AST
Yours:
Mine:
Keep taking your rapamycin, you will catch up.
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